ES8604520A1 - Procedimiento para preparar derivados de 2(1h)-piridona - Google Patents
Procedimiento para preparar derivados de 2(1h)-piridonaInfo
- Publication number
- ES8604520A1 ES8604520A1 ES538156A ES538156A ES8604520A1 ES 8604520 A1 ES8604520 A1 ES 8604520A1 ES 538156 A ES538156 A ES 538156A ES 538156 A ES538156 A ES 538156A ES 8604520 A1 ES8604520 A1 ES 8604520A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- composition containing
- pyridone derivatives
- pyridone
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 2(1H)-PIRIDONA. CONSISTENTE EN: AMINAR UN COMPUESTO DE FORMULA (IV) EN CONDICIONES FUERTEMENTE ALCALINAS, EN PRESENCIA DE UN HIDROXIDO DE METAL ALCALINO Y BROMO, EN AGUA Y A UNA TEMPERATURA ENTRE 50JC Y 100JC, PARA OBTENER COMPUESTOS DE FORMULA (I), QUE SE PUEDEN AISLAR EN FORMA LIBRE O EN FORMA DE ADICION DE ACIDOS. SIENDO: R, GRUPO AMINO Y A) R1 ES I) FENILO SUSTITUIDO POR 1 O 2 GRUPOS ELEGIDOS ENTRE UN GRUPO -(CH2)MX Y UN GRUPO -(CH2)NY EN DONDE M F 0 A 4, N F 1 A 4, X, CIANO , CARBOXI Y OTROS E Y, HIDROXI, AMINO Y OTROS; O II) FENILO DISUSTITUIDO POR UN GRUPO DE LOS CITADOS EN I) Y POR UN SUSTITUYENTE ELEGIDO ENTRE ALQUILO C1-C4, ALCOXI C1-4 Y HALOGENO DE NUMERO ATOMICO DE 9 A 35; Y R2, H O ALQUILO C1-4; O BIEN B) R1, H O ALQUILO C1-4 O TIENE EL SIGNIFICADO DE A) Y R2 TIENE EL SIGNIFICADO QUE R1 EN A).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH309182 | 1982-05-18 | ||
CH308782 | 1982-05-18 | ||
CH83783 | 1983-02-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604520A1 true ES8604520A1 (es) | 1986-02-01 |
ES538156A0 ES538156A0 (es) | 1986-02-01 |
Family
ID=27172460
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522434A Granted ES522434A0 (es) | 1982-05-18 | 1983-05-16 | Procedimiento para preparar derivados de 2(1h) piridona. |
ES538156A Expired ES8604520A1 (es) | 1982-05-18 | 1984-11-30 | Procedimiento para preparar derivados de 2(1h)-piridona |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522434A Granted ES522434A0 (es) | 1982-05-18 | 1983-05-16 | Procedimiento para preparar derivados de 2(1h) piridona. |
Country Status (21)
Country | Link |
---|---|
US (1) | US4530842A (es) |
AU (1) | AU563076B2 (es) |
CA (1) | CA1240330A (es) |
CH (1) | CH659468A5 (es) |
DE (1) | DE3317289A1 (es) |
DK (1) | DK218183A (es) |
ES (2) | ES522434A0 (es) |
FI (1) | FI831619L (es) |
FR (1) | FR2527206B1 (es) |
GB (1) | GB2121037B (es) |
HU (1) | HU190839B (es) |
IE (1) | IE55133B1 (es) |
IL (1) | IL68710A (es) |
IT (1) | IT1197655B (es) |
MY (1) | MY8600466A (es) |
NL (1) | NL8301721A (es) |
NZ (1) | NZ204243A (es) |
PH (1) | PH20791A (es) |
PT (1) | PT76695B (es) |
SE (1) | SE455866B (es) |
WO (1) | WO1983004024A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3406329A1 (de) * | 1984-02-22 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Pyridone |
US4657919A (en) * | 1984-08-03 | 1987-04-14 | E. I. Du Pont De Nemours & Co. | Pyridone esters as inotropic agents |
ATE77817T1 (de) | 1985-04-30 | 1992-07-15 | Dresden Arzneimittel | 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
GB8621217D0 (en) * | 1986-09-03 | 1986-10-08 | Ici Plc | Chemical compounds |
GB8809481D0 (en) * | 1988-04-21 | 1988-05-25 | Smith Kline French Lab | Chemical compounds |
US5254571A (en) * | 1988-04-21 | 1993-10-19 | Smith Kline & French Laboratories Ltd. | Chemical compounds |
GB8923131D0 (en) * | 1989-10-13 | 1989-11-29 | Smith Kline French Lab | Chemical compounds |
AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
AR037233A1 (es) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
WO2024109919A1 (zh) * | 2022-11-24 | 2024-05-30 | 盛睿泽华医药科技(苏州)有限公司 | 吡啶酮化合物及其制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7008619A (es) * | 1969-06-25 | 1970-12-29 | Merck & Co Inc | |
US3814771A (en) * | 1970-11-19 | 1974-06-04 | T Shen | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones |
US3718743A (en) * | 1970-11-19 | 1973-02-27 | Merck & Co Inc | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation |
US4209626A (en) * | 1979-03-15 | 1980-06-24 | American Cyanamid Company | Substituted 6-phenyl-1,2,4-triazolo[4,3-a]pyridines |
US4244953A (en) * | 1979-10-24 | 1981-01-13 | American Cyanamid Company | Substituted 6-phenyl-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyridines |
DE3106460A1 (de) * | 1980-03-03 | 1982-01-28 | Sandoz-Patent-GmbH, 7850 Lörrach | 2(1h)-pyridinon-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen |
JPS56125335A (en) * | 1980-03-06 | 1981-10-01 | Fujisawa Pharmaceut Co Ltd | 1,4-naphthoquinone derivative, its preparation, and its use |
IL65278A0 (en) * | 1981-03-30 | 1982-05-31 | Sterling Drug Inc | 3-amino-5-(substituted)-2(1h)-pyridinones and corresponding 3-cyano compounds,their preparation and pharmaceutical compositions containing them |
US4465686A (en) * | 1981-09-08 | 1984-08-14 | Sterling Drug Inc. | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation |
-
1983
- 1983-05-09 FR FR8307851A patent/FR2527206B1/fr not_active Expired
- 1983-05-10 FI FI831619A patent/FI831619L/fi not_active Application Discontinuation
- 1983-05-11 DE DE19833317289 patent/DE3317289A1/de not_active Withdrawn
- 1983-05-12 US US06/493,933 patent/US4530842A/en not_active Expired - Fee Related
- 1983-05-13 NL NL8301721A patent/NL8301721A/nl not_active Application Discontinuation
- 1983-05-13 CH CH244/84A patent/CH659468A5/de not_active IP Right Cessation
- 1983-05-13 WO PCT/CH1983/000062 patent/WO1983004024A1/de unknown
- 1983-05-13 PH PH28899A patent/PH20791A/en unknown
- 1983-05-16 GB GB08313408A patent/GB2121037B/en not_active Expired
- 1983-05-16 SE SE8302751A patent/SE455866B/sv not_active IP Right Cessation
- 1983-05-16 NZ NZ204243A patent/NZ204243A/en unknown
- 1983-05-16 DK DK218183A patent/DK218183A/da not_active Application Discontinuation
- 1983-05-16 CA CA000428204A patent/CA1240330A/en not_active Expired
- 1983-05-16 PT PT76695A patent/PT76695B/pt unknown
- 1983-05-16 HU HU831697A patent/HU190839B/hu not_active IP Right Cessation
- 1983-05-16 AU AU14579/83A patent/AU563076B2/en not_active Ceased
- 1983-05-16 IL IL68710A patent/IL68710A/xx unknown
- 1983-05-16 ES ES522434A patent/ES522434A0/es active Granted
- 1983-05-17 IT IT48309/83A patent/IT1197655B/it active
- 1983-05-17 IE IE1145/83A patent/IE55133B1/en unknown
-
1984
- 1984-11-30 ES ES538156A patent/ES8604520A1/es not_active Expired
-
1986
- 1986-12-30 MY MY466/86A patent/MY8600466A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DK218183A (da) | 1983-11-19 |
PT76695B (en) | 1986-01-28 |
HU190839B (en) | 1986-11-28 |
GB8313408D0 (en) | 1983-06-22 |
SE8302751D0 (sv) | 1983-05-16 |
ES8504129A1 (es) | 1985-04-01 |
US4530842A (en) | 1985-07-23 |
IT1197655B (it) | 1988-12-06 |
SE455866B (sv) | 1988-08-15 |
AU563076B2 (en) | 1987-06-25 |
IE831145L (en) | 1983-11-18 |
FR2527206A1 (fr) | 1983-11-25 |
CA1240330A (en) | 1988-08-09 |
FI831619A0 (fi) | 1983-05-10 |
DE3317289A1 (de) | 1983-11-24 |
GB2121037B (en) | 1985-09-04 |
DK218183D0 (da) | 1983-05-16 |
GB2121037A (en) | 1983-12-14 |
NL8301721A (nl) | 1983-12-16 |
PT76695A (en) | 1983-06-01 |
MY8600466A (en) | 1986-12-31 |
PH20791A (en) | 1987-04-14 |
ES522434A0 (es) | 1985-04-01 |
IT8348309A0 (it) | 1983-05-17 |
SE8302751L (sv) | 1983-11-19 |
AU1457983A (en) | 1983-11-24 |
FR2527206B1 (fr) | 1986-12-05 |
NZ204243A (en) | 1986-03-14 |
FI831619L (fi) | 1983-11-19 |
CH659468A5 (de) | 1987-01-30 |
WO1983004024A1 (en) | 1983-11-24 |
IE55133B1 (en) | 1990-06-06 |
IL68710A0 (en) | 1983-09-30 |
ES538156A0 (es) | 1986-02-01 |
IL68710A (en) | 1986-09-30 |
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