ES8404993A1 - Procedimiento para preparar derivados de piridina - Google Patents

Procedimiento para preparar derivados de piridina

Info

Publication number
ES8404993A1
ES8404993A1 ES525122A ES525122A ES8404993A1 ES 8404993 A1 ES8404993 A1 ES 8404993A1 ES 525122 A ES525122 A ES 525122A ES 525122 A ES525122 A ES 525122A ES 8404993 A1 ES8404993 A1 ES 8404993A1
Authority
ES
Spain
Prior art keywords
preparation
omeprazole
intermediates
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525122A
Other languages
English (en)
Other versions
ES525122A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20347627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8404993(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hassle AB filed Critical Hassle AB
Publication of ES525122A0 publication Critical patent/ES525122A0/es
Publication of ES8404993A1 publication Critical patent/ES8404993A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDINA, DE FORMULA (I), EN LA QUE R ES HIDROGENO O METILO.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I), CON UN AGENTE DE NITRACION, TAL COMO ACIDO NITRICO EN ACIDO SULFURICO; SEGUIDA DEL TRATAMIENTO DEL COMPUESTO FORMADO CON UNA DISOLUCION DE ANION METOXIDO EN METANOL, PREPARADA A PARTIR DE METANOL E HIDROXIDO SODICO.ESTOS COMPUESTOS TIENEN APLICACION COMO INTERMEDIOS EN LA PREPARACION DE MEDICAMENTOS QUE TIENEN EFECTOS CITROPROTECTORES GASTROINTESTINALES, E INHIBIDORES DELA SECRECION DEL ACIDO GASTRICO.
ES525122A 1982-08-26 1983-08-24 Procedimiento para preparar derivados de piridina Expired ES8404993A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8204879A SE8204879D0 (sv) 1982-08-26 1982-08-26 Novel chemical intermediates

Publications (2)

Publication Number Publication Date
ES525122A0 ES525122A0 (es) 1984-05-16
ES8404993A1 true ES8404993A1 (es) 1984-05-16

Family

ID=20347627

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525122A Expired ES8404993A1 (es) 1982-08-26 1983-08-24 Procedimiento para preparar derivados de piridina

Country Status (28)

Country Link
US (2) US4544750A (es)
EP (1) EP0103553B1 (es)
JP (1) JPS5959662A (es)
KR (1) KR880000091B1 (es)
AT (1) ATE40884T1 (es)
AU (1) AU560028B2 (es)
CA (1) CA1234118A (es)
CY (1) CY1328A (es)
DD (1) DD233126A5 (es)
DE (2) DE3379222D1 (es)
DK (1) DK381583A (es)
ES (1) ES8404993A1 (es)
FI (1) FI79701C (es)
GB (1) GB2126226B (es)
GR (1) GR79374B (es)
HK (1) HK19486A (es)
HU (1) HU189738B (es)
IE (1) IE55865B1 (es)
IL (1) IL69175A (es)
IS (1) IS1438B6 (es)
MY (1) MY8600503A (es)
NO (1) NO164093C (es)
NZ (1) NZ204959A (es)
OA (1) OA07498A (es)
PH (1) PH17786A (es)
PT (1) PT77249B (es)
SE (1) SE8204879D0 (es)
ZA (1) ZA835143B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2060541A1 (es) * 1993-02-26 1994-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
ES2067407A1 (es) * 1991-11-21 1995-03-16 Genesis Para La Investigacion Perfeccionamientos en el objeto de la patente 9102594 por procedimiento de obtencion de derivados de piridina.

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
SE8504409D0 (sv) * 1985-09-24 1985-09-24 Haessle Ab Novel chemical intermediates
ES2053533T3 (es) * 1986-04-17 1994-08-01 Ici Plc Derivados de esteres de acido piridil-acrilico, un proceso para su preparacion y su uso como fungicidas.
US5221316A (en) * 1986-04-17 1993-06-22 Imperial Chemical Industries Plc Fungicides
US4920230A (en) * 1987-06-29 1990-04-24 Takeda Chemical Industries, Ltd. Method of producing nitrogen-containing heteroaromatic compounds having an alkoxy group
AT391693B (de) * 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
ES2097089B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
WO1999033807A2 (en) * 1997-12-24 1999-07-08 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives (intermediates) employing free radical substitution reactions to functionalize the 2-position of the pyridine
GB9717849D0 (en) * 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6350876B2 (en) 1998-01-26 2002-02-26 Kuraray Co., Ltd. 4-chloro-3,5-dimethyl-2-sulfonyl pyridines
KR100396431B1 (ko) * 1998-01-26 2003-09-02 가부시키가이샤 구라레 2-술포닐피리딘 유도체 및 2-[((2-피리딜)메틸)티오]-1ｈ-벤즈이
US6303787B1 (en) 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
WO2000000474A1 (en) * 1998-06-26 2000-01-06 Russinsky Limited Pyridine building blocks as intermediates in the synthesis of pharmaceutically active compounds
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
GB9921578D0 (en) * 1999-09-13 1999-11-17 Cipla Limited Omeprazole synthesis
ES2171116B1 (es) 2000-04-14 2003-08-01 Esteve Quimica Sa Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
AU2000258410A1 (en) * 2000-07-28 2003-12-02 Herbex, Produtos Quimicos, Sa New method for the preparation of the anti-ulcer compounds omeprazole, lansoprazole and pantoprazole
ATE429431T1 (de) 2001-05-11 2009-05-15 Tibotec Pharm Ltd 2-amino-benzoxazol-suphonamide als breitspektrum- hiv-protease-inhibitoren
WO2003063840A2 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
FR2848555B1 (fr) 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CN100376574C (zh) * 2006-06-14 2008-03-26 浙江大学 泰妥拉唑的制备方法
EA200900985A1 (ru) 2007-01-31 2009-12-30 Крка, Товарна Здравил, Д. Д., Ново Место Способ получения оптически чистого омепразола
CN101648912B (zh) * 2009-09-14 2012-07-04 南京第一农药集团有限公司 一种4-硝基-3,5-二甲基吡啶-n-氧化物的连续化制备方法
CN101648907B (zh) * 2009-09-14 2011-08-03 南京第一农药集团有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的纯化方法
CN102603620B (zh) * 2012-01-13 2014-10-29 江苏中邦制药有限公司 一种氯甲基吡啶或其吡啶衍生物盐酸盐的合成方法
WO2021061991A1 (en) 2019-09-24 2021-04-01 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases
CN112142653B (zh) * 2020-10-22 2022-02-11 成都百泉生物医药科技有限公司 奥美拉唑中间体的制备方法
CN113307773A (zh) * 2021-06-17 2021-08-27 上海毕得医药科技股份有限公司 6-溴-3-甲氧基-1-苯基-1h-吲唑及其合成方法和应用
CN114805193B (zh) * 2022-04-19 2023-06-20 南京红太阳医药研究院有限公司 一种奥美拉唑中间体的制备方法

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US2735851A (en) * 1956-02-21 Alkanolpykroine-n-oxides
US2663711A (en) * 1951-12-08 1953-12-22 Du Pont Process for the preparation of pyridine alcohols from pyridine n-oxides
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
KR840002371A (ko) * 1981-11-05 1984-06-25 귄터 미카엘, 헤르페르트 수키 치환된 벤즈 이미다졸의 제조방법

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2067407A1 (es) * 1991-11-21 1995-03-16 Genesis Para La Investigacion Perfeccionamientos en el objeto de la patente 9102594 por procedimiento de obtencion de derivados de piridina.
ES2105953A1 (es) * 1991-11-21 1997-10-16 Genesis Para La Investigacion Perfeccionamientos en el objeto de la patente de invencion 9102594 por procedimiento de obtencion de compuestos derivados de piridina.
ES2060541A1 (es) * 1993-02-26 1994-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.

Also Published As

Publication number Publication date
DK381583D0 (da) 1983-08-19
NO164093B (no) 1990-05-21
OA07498A (en) 1985-03-31
HK19486A (en) 1986-03-27
FI79701C (fi) 1990-02-12
DE3379222D1 (en) 1989-03-30
US4620008A (en) 1986-10-28
IS2845A7 (is) 1984-02-27
IL69175A (en) 1987-01-30
DE103553T1 (de) 1984-09-27
JPS6353987B2 (es) 1988-10-26
ES525122A0 (es) 1984-05-16
EP0103553A1 (en) 1984-03-21
NO164093C (no) 1990-08-29
DK381583A (da) 1984-02-27
FI833047A0 (fi) 1983-08-25
IL69175A0 (en) 1983-11-30
KR840005718A (ko) 1984-11-15
ATE40884T1 (de) 1989-03-15
IE831787L (en) 1984-02-26
AU560028B2 (en) 1987-03-26
FI79701B (fi) 1989-10-31
DD233126A5 (de) 1986-02-19
JPS5959662A (ja) 1984-04-05
CY1328A (en) 1986-06-27
MY8600503A (en) 1986-12-31
IE55865B1 (en) 1991-01-30
NZ204959A (en) 1985-12-13
AU1710183A (en) 1984-03-01
EP0103553B1 (en) 1989-02-22
PT77249A (en) 1983-09-01
GR79374B (es) 1984-10-22
IS1438B6 (is) 1990-09-25
PH17786A (en) 1984-12-13
ZA835143B (en) 1984-04-25
HU189738B (en) 1986-07-28
CA1234118A (en) 1988-03-15
PT77249B (en) 1986-07-14
GB2126226A (en) 1984-03-21
GB8322866D0 (en) 1983-09-28
US4544750A (en) 1985-10-01
FI833047A (fi) 1984-02-27
GB2126226B (en) 1985-09-18
NO832794L (no) 1984-02-27
KR880000091B1 (ko) 1988-02-23
SE8204879D0 (sv) 1982-08-26

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