EA200900985A1 - Способ получения оптически чистого омепразола - Google Patents

Способ получения оптически чистого омепразола

Info

Publication number
EA200900985A1
EA200900985A1 EA200900985A EA200900985A EA200900985A1 EA 200900985 A1 EA200900985 A1 EA 200900985A1 EA 200900985 A EA200900985 A EA 200900985A EA 200900985 A EA200900985 A EA 200900985A EA 200900985 A1 EA200900985 A1 EA 200900985A1
Authority
EA
Eurasian Patent Office
Prior art keywords
omeprazol
obtaining optical
optical pure
optically pure
producing
Prior art date
Application number
EA200900985A
Other languages
English (en)
Inventor
Игор Плапер
Аница Пецавар
Берта Котар-Йордан
Наталия Зайц
Миха Врбинц
Антон Коцевар
Митя Пелко
Мирослав Веверка
Ева Веверкова
Янез Смодис
Рок Зупет
Original Assignee
Крка, Товарна Здравил, Д. Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SI200700024A external-priority patent/SI22447A/sl
Priority claimed from SI200700078A external-priority patent/SI22490A/sl
Priority claimed from EP07019823A external-priority patent/EP2048144A1/en
Application filed by Крка, Товарна Здравил, Д. Д., Ново Место filed Critical Крка, Товарна Здравил, Д. Д., Ново Место
Publication of EA200900985A1 publication Critical patent/EA200900985A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Abstract

Настоящее изобретение относится к способу получения, по существу, оптически чистого омепразола или его фармацевтически приемлемой соли или сольвата. Изобретение также относится к способу получения фармацевтической композиции, содержащей, по существу, оптически чистый омепразол или его фармацевтически приемлемую соль или сольват, и к полупродуктам, полезным для получения оптически чистого омепразола.
EA200900985A 2007-01-31 2008-01-31 Способ получения оптически чистого омепразола EA200900985A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SI200700024A SI22447A (sl) 2007-01-31 2007-01-31 Nov postopek za pripravo enantiomerno obogatenega omeprazola
SI200700078A SI22490A (sl) 2007-03-28 2007-03-28 Nov postopek za pripravo enantiomerno obogatenegaomeprazola
EP07019823A EP2048144A1 (en) 2007-10-10 2007-10-10 Process for the preparation of optically pure omeprazole via salt formation with a chiral amine
PCT/EP2008/051230 WO2008092939A2 (en) 2007-01-31 2008-01-31 Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic separation

Publications (1)

Publication Number Publication Date
EA200900985A1 true EA200900985A1 (ru) 2009-12-30

Family

ID=39638287

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900985A EA200900985A1 (ru) 2007-01-31 2008-01-31 Способ получения оптически чистого омепразола

Country Status (3)

Country Link
EP (1) EP2114919A2 (ru)
EA (1) EA200900985A1 (ru)
WO (1) WO2008092939A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2346854A4 (en) * 2008-11-18 2012-10-17 Hetero Research Foundation OPTICAL PURIFICATION OF ESOMEPRAZOLE
WO2011042910A2 (en) * 2009-10-09 2011-04-14 Hetero Research Foundation Optical resolution of substituted 2-(2- pyridinylmethylsulphinyl)-1h-benzimidazoles
US8748619B2 (en) 2009-11-12 2014-06-10 Hetero Research Foundation Process for the resolution of omeprazole
WO2013088272A1 (en) * 2011-12-14 2013-06-20 Wockhardt Limited Pharmaceutical composition comprising esomeprazole magnesium dihydrate
CN102775418B (zh) * 2012-06-11 2014-12-24 中国人民解放军第四军医大学 新型手性季铵盐相转移催化剂的合成及应用
CN106632248A (zh) * 2016-09-30 2017-05-10 青岛云天生物技术有限公司 一种左旋泮托拉唑钠的制备工艺
CN112666304B (zh) * 2019-10-15 2022-12-09 扬子江药业集团有限公司 一种艾司奥美拉唑钠药物中对映异构体的检测方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
SE8204879D0 (sv) 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
DK171989B1 (da) 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
AT391693B (de) 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
ES2026761A6 (es) 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
WO1993006097A1 (en) 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
ATE259807T1 (de) * 1996-06-05 2004-03-15 Lindner Wolfgang Prof Dr Auf cinchonan basierte chirale selektoren zur trennung von stereoisomeren
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
UA72748C2 (en) 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
DE69911159T2 (de) * 1999-01-06 2004-06-24 Técnimede-Sociedade Técnico-Medicinal, S.A. Cyclodextrin Einschlusskomplexe mit Aminosäuresalzen von Benzimidazolderivaten, deren Herstellung, sowie diese enthaltende pharmazeutische Zusammensetzungen
SI20875A (sl) 2001-04-25 2002-10-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristalna oblika omeprazola
SE0104295D0 (sv) 2001-12-18 2001-12-18 Astrazeneca Ab New process
WO2003074514A1 (en) 2002-03-05 2003-09-12 Astrazeneca Ab Alkylammonium salts of omeprazole and esomeprazole
BR0315574A (pt) 2002-10-22 2005-09-20 Ranbaxy Lab Ltd Forma amorfa de esomeprazol, composição farmacêutica contendo o mesmo e processo para sua preparação
WO2004099182A1 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Zinc salt of (s)-omeprazole
EP1633736A1 (en) 2003-05-05 2006-03-15 Ranbaxy Laboratories Limited Barium salt of benzimidazole derivative
SE0302382D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts II
SE0302381D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts I
EP1726305A1 (de) 2005-05-25 2006-11-29 Ratiopharm GmbH Zinksalz des Omeprazols und dessen Enantiomere
ES2281292B1 (es) * 2006-03-08 2008-06-16 Quimica Sintetica S.A. Nuevas sales de esomeprazol. procedimiento de preparacion y composiciones farmaceuticas que las comprenden.

Also Published As

Publication number Publication date
EP2114919A2 (en) 2009-11-11
WO2008092939A2 (en) 2008-08-07
WO2008092939A3 (en) 2009-01-29

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