EA200900985A1 - METHOD OF OBTAINING OPTICAL PURE OMEPRAZOL - Google Patents

METHOD OF OBTAINING OPTICAL PURE OMEPRAZOL

Info

Publication number
EA200900985A1
EA200900985A1 EA200900985A EA200900985A EA200900985A1 EA 200900985 A1 EA200900985 A1 EA 200900985A1 EA 200900985 A EA200900985 A EA 200900985A EA 200900985 A EA200900985 A EA 200900985A EA 200900985 A1 EA200900985 A1 EA 200900985A1
Authority
EA
Eurasian Patent Office
Prior art keywords
omeprazol
obtaining optical
optical pure
optically pure
producing
Prior art date
Application number
EA200900985A
Other languages
Russian (ru)
Inventor
Игор Плапер
Аница Пецавар
Берта Котар-Йордан
Наталия Зайц
Миха Врбинц
Антон Коцевар
Митя Пелко
Мирослав Веверка
Ева Веверкова
Янез Смодис
Рок Зупет
Original Assignee
Крка, Товарна Здравил, Д. Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SI200700024A external-priority patent/SI22447A/en
Priority claimed from SI200700078A external-priority patent/SI22490A/en
Priority claimed from EP07019823A external-priority patent/EP2048144A1/en
Application filed by Крка, Товарна Здравил, Д. Д., Ново Место filed Critical Крка, Товарна Здравил, Д. Д., Ново Место
Publication of EA200900985A1 publication Critical patent/EA200900985A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Abstract

Настоящее изобретение относится к способу получения, по существу, оптически чистого омепразола или его фармацевтически приемлемой соли или сольвата. Изобретение также относится к способу получения фармацевтической композиции, содержащей, по существу, оптически чистый омепразол или его фармацевтически приемлемую соль или сольват, и к полупродуктам, полезным для получения оптически чистого омепразола.The present invention relates to a method for producing substantially optically pure omeprazole or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to a method for producing a pharmaceutical composition comprising essentially optically pure omeprazole or a pharmaceutically acceptable salt or solvate thereof, and to intermediates useful for producing optically pure omeprazole.

EA200900985A 2007-01-31 2008-01-31 METHOD OF OBTAINING OPTICAL PURE OMEPRAZOL EA200900985A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SI200700024A SI22447A (en) 2007-01-31 2007-01-31 New procedure for preparation of enantiomerically enriched omeprazole
SI200700078A SI22490A (en) 2007-03-28 2007-03-28 New procedure for preparation of enantiomerically enriched omeprazole
EP07019823A EP2048144A1 (en) 2007-10-10 2007-10-10 Process for the preparation of optically pure omeprazole via salt formation with a chiral amine
PCT/EP2008/051230 WO2008092939A2 (en) 2007-01-31 2008-01-31 Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic separation

Publications (1)

Publication Number Publication Date
EA200900985A1 true EA200900985A1 (en) 2009-12-30

Family

ID=39638287

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900985A EA200900985A1 (en) 2007-01-31 2008-01-31 METHOD OF OBTAINING OPTICAL PURE OMEPRAZOL

Country Status (3)

Country Link
EP (1) EP2114919A2 (en)
EA (1) EA200900985A1 (en)
WO (1) WO2008092939A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2346854A4 (en) 2008-11-18 2012-10-17 Hetero Research Foundation Optical purification of esomeprazole
US8420822B2 (en) 2009-10-09 2013-04-16 Hetero Research Foundation Optical resolution of substituted 2-(2-pyridinylmethylsulphinyl)-1H-benzimidazoles
WO2011058569A1 (en) 2009-11-12 2011-05-19 Hetero Research Foundation Process for the resolution of omeprazole
WO2013088272A1 (en) * 2011-12-14 2013-06-20 Wockhardt Limited Pharmaceutical composition comprising esomeprazole magnesium dihydrate
CN102775418B (en) * 2012-06-11 2014-12-24 中国人民解放军第四军医大学 Synthesis and application of novel chiral quaternary ammonium salt phase-transfer catalyst
CN106632248A (en) * 2016-09-30 2017-05-10 青岛云天生物技术有限公司 Preparation process of (S)-pantoprazole sodium
CN112666304B (en) * 2019-10-15 2022-12-09 扬子江药业集团有限公司 Method for detecting enantiomer in esomeprazole sodium medicine

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (en) 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
SE8204879D0 (en) 1982-08-26 1982-08-26 Haessle Ab NOVEL CHEMICAL INTERMEDIATES
DK171989B1 (en) 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Process for the preparation of 2- (2-pyridylmethylsulfinyl) benzimidazoles
AT391693B (en) 1988-11-15 1990-11-12 Cl Pharma METHOD FOR PRODUCING 3-5-DIMETHYL-4METHOXYPYRIDINE DERIVATIVES AND NEW INTERMEDIATE PRODUCT THEREFOR
SE9002043D0 (en) 1990-06-07 1990-06-07 Astra Ab IMPROVED METHOD FOR SYNTHESIS
ES2026761A6 (en) 1990-10-31 1992-05-01 Genesis Para La Investigacion A process for the preparation of omeprazol.
NZ244301A (en) 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
SE9301830D0 (en) * 1993-05-28 1993-05-28 Ab Astra NEW COMPOUNDS
US6313247B1 (en) * 1996-06-05 2001-11-06 Wolfgang Lindner Cinchonan based chiral selectors for separation of stereoisomers
SE510650C2 (en) 1997-05-30 1999-06-14 Astra Ab New association
UA72748C2 (en) 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
DE69911159T2 (en) 1999-01-06 2004-06-24 Técnimede-Sociedade Técnico-Medicinal, S.A. Cyclodextrin inclusion complexes with amino acid salts of benzimidazole derivatives, their preparation and pharmaceutical compositions containing them
SI20875A (en) 2001-04-25 2002-10-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Crystal form of omeprazole
SE0104295D0 (en) 2001-12-18 2001-12-18 Astrazeneca Ab New process
PT1487818E (en) 2002-03-05 2007-07-18 Astrazeneca Ab Alkylammonium salts of omeprazole and esomeprazole
AU2003278406A1 (en) 2002-10-22 2004-05-13 Ranbaxy Laboratories Limited Amorphous form of esomeprazole salts
WO2004099182A1 (en) 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Zinc salt of (s)-omeprazole
WO2004099181A1 (en) 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Barium salt of benzimidazole derivative
SE0302382D0 (en) 2003-09-04 2003-09-04 Astrazeneca Ab New salts II
SE0302381D0 (en) 2003-09-04 2003-09-04 Astrazeneca Ab New salts I
EP1726305A1 (en) 2005-05-25 2006-11-29 Ratiopharm GmbH Zinc salt of omeprazole and its enantiomers
ES2281292B1 (en) * 2006-03-08 2008-06-16 Quimica Sintetica S.A. NEW SALTS OF ESOMEPRAZOL. PROCEDURE OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM.

Also Published As

Publication number Publication date
WO2008092939A3 (en) 2009-01-29
EP2114919A2 (en) 2009-11-11
WO2008092939A2 (en) 2008-08-07

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