EA200870262A1 - Способ получения оптических активных хиральных аминов - Google Patents

Способ получения оптических активных хиральных аминов

Info

Publication number
EA200870262A1
EA200870262A1 EA200870262A EA200870262A EA200870262A1 EA 200870262 A1 EA200870262 A1 EA 200870262A1 EA 200870262 A EA200870262 A EA 200870262A EA 200870262 A EA200870262 A EA 200870262A EA 200870262 A1 EA200870262 A1 EA 200870262A1
Authority
EA
Eurasian Patent Office
Prior art keywords
optical active
obtaining optical
chiral amines
active chiral
amines
Prior art date
Application number
EA200870262A
Other languages
English (en)
Other versions
EA017070B1 (ru
Inventor
Карен Робинс
Уве Борншойер
Маттиас Хене
Original Assignee
Лонца Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лонца Аг filed Critical Лонца Аг
Publication of EA200870262A1 publication Critical patent/EA200870262A1/ru
Publication of EA017070B1 publication Critical patent/EA017070B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Настоящее изобретение относится к получению оптически чистых вторичных аминов, которые могут быть использованы как промежуточные соединения в синтезе, например, фармацевтических продуктов.
EA200870262A 2006-02-13 2007-02-13 Способ получения оптических активных хиральных аминов EA017070B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06002859A EP1818411A1 (en) 2006-02-13 2006-02-13 Process for the preparation of optically active chiral amines
PCT/EP2007/001222 WO2007093372A1 (en) 2006-02-13 2007-02-13 Process for the preparation of optically active chiral amines

Publications (2)

Publication Number Publication Date
EA200870262A1 true EA200870262A1 (ru) 2009-02-27
EA017070B1 EA017070B1 (ru) 2012-09-28

Family

ID=36686005

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870262A EA017070B1 (ru) 2006-02-13 2007-02-13 Способ получения оптических активных хиральных аминов

Country Status (17)

Country Link
US (2) US9074228B2 (ru)
EP (4) EP1818411A1 (ru)
JP (2) JP5430945B2 (ru)
KR (1) KR101294499B1 (ru)
CN (1) CN101384723B (ru)
AT (1) ATE469233T1 (ru)
AU (1) AU2007214717B2 (ru)
BR (1) BRPI0707454A2 (ru)
CA (1) CA2637821A1 (ru)
DE (1) DE602007006765D1 (ru)
DK (1) DK1987152T3 (ru)
EA (1) EA017070B1 (ru)
ES (3) ES2767898T3 (ru)
IL (3) IL192637A (ru)
MX (1) MX2008010416A (ru)
PT (1) PT1987152E (ru)
WO (1) WO2007093372A1 (ru)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1818411A1 (en) * 2006-02-13 2007-08-15 Lonza AG Process for the preparation of optically active chiral amines
EP2022852B8 (en) * 2006-05-29 2017-08-23 Kaneka Corporation Method for production of optically active amine compound, recombinant vector, and transformant carrying the vector
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
DE102007042600A1 (de) * 2007-09-07 2009-03-12 Evonik Degussa Gmbh Verfahren zur Herstellung von enantiomerenangereichten Aminen
DE102007060705A1 (de) * 2007-12-17 2009-06-18 Evonik Degussa Gmbh ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen
AU2008345097A1 (en) 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
HUE052297T2 (hu) 2009-01-08 2021-04-28 Codexis Inc Transzamináz polipeptidek
ES2448816T3 (es) 2009-02-26 2014-03-17 Codexis, Inc. Biocatalizadores de transaminasa
RU2011142780A (ru) * 2009-03-23 2013-04-27 Аминолюкс, Инк. Способ получения оптически чистых аминокислот
US8921079B2 (en) 2009-06-22 2014-12-30 Codexis, Inc. Transaminase reactions
CA2769795C (en) 2009-08-05 2020-01-07 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
US8577622B2 (en) 2009-09-02 2013-11-05 Lonza Ag Process for the identification and preparation of a (R)-specific omega-transaminase
HUE038434T2 (hu) 2010-06-17 2018-10-29 Codexis Inc Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
WO2012037217A1 (en) 2010-09-14 2012-03-22 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
EP2623595B1 (en) 2010-09-28 2016-11-02 Kaneka Corporation Novel transaminase showing high activity for glutamic acid, gene encoding same, and method for utilization thereof
WO2012124639A1 (ja) 2011-03-11 2012-09-20 株式会社カネカ 改変型アミノ基転移酵素、その遺伝子、およびそれらを利用した光学活性アミノ化合物の製造方法
KR101479718B1 (ko) 2012-07-06 2015-01-08 연세대학교 산학협력단 오메가 트랜스아미나아제의 조기질 순환을 이용한 광학 활성 아미노산의 제조방법
EP2909327A1 (en) * 2012-10-18 2015-08-26 Sandoz AG A process for preparing indoline derivatives
WO2014092496A1 (ko) * 2012-12-13 2014-06-19 연세대학교 산학협력단 탈라세믹화를 이용한 광학 활성 아민 화합물의 제조방법
KR101493311B1 (ko) * 2012-12-13 2015-02-16 연세대학교 산학협력단 광학 활성 아민 및 호모알라닌의 제조방법
KR101479717B1 (ko) * 2013-02-27 2015-01-08 연세대학교 산학협력단 트랜스아미나제를 이용한 광학활성 알킬아민과 아릴알킬아민의 동시생산방법
KR101910259B1 (ko) 2013-11-26 2018-12-19 아심켐 래보러토리즈 (톈진) 컴퍼니, 리미티드 트랜스아미나제 및 그 응용
CN103865964A (zh) * 2014-03-14 2014-06-18 上海朴颐化学科技有限公司 转氨酶法合成(r)-3-氨基哌啶的方法
MX2017015681A (es) 2015-06-04 2018-09-11 Pellepharm Inc Formulaciones topicas para suministrar compuestos inhibidores de hedgehog y uso de los mismos.
CN105112468B (zh) * 2015-10-14 2019-01-08 厦门大学 一种多酶耦联体系制备手性胺的方法
CN105200089B (zh) * 2015-10-15 2018-09-11 江苏暨明医药科技有限公司 (s)-1-叔丁氧羰基-3-羟基哌啶制备方法及其装置
EP3423585A1 (en) 2016-03-02 2019-01-09 Agrimetis, LLC Methods for making l-glufosinate
CN111349667B (zh) * 2016-11-01 2022-05-06 凯莱英医药集团（天津）股份有限公司 一种手性氨基杂环化合物及其衍生物的制备方法
JPWO2018207888A1 (ja) * 2017-05-10 2020-03-12 株式会社カネカ ラメルテオンの製造法
CN107805648B (zh) * 2017-10-10 2020-09-11 凯莱英生命科学技术(天津)有限公司 制备具有多个手性中心的胺化合物的方法
WO2020051188A1 (en) 2018-09-05 2020-03-12 Agrimetis, Llc Methods for improving yields of l-glufosinate
CN109370998B (zh) * 2018-11-30 2020-08-04 江南大学 一种催化效率提高的ω-转氨酶突变体I215F
CN110724675B (zh) * 2019-10-31 2021-02-02 宁波酶赛生物工程有限公司 转氨酶催化剂和酶法合成(r)-1-叔丁氧羰基-3-氨基哌啶的方法
CN112626142B (zh) * 2020-12-17 2022-10-18 永农生物科学有限公司 利用生物多酶偶联法制备l-草铵膦的方法
CN112410383B (zh) * 2020-12-17 2022-07-12 永农生物科学有限公司 利用生物多酶偶联法制备l-草铵膦的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193902B (en) 1983-09-01 1987-12-28 Genetics Inst Process for preparing l-amino acids by means of transamination
ATE191008T1 (de) 1986-06-04 2000-04-15 Hoechst Schering Agrevo Gmbh Verfahren zur herstellung von l-tertiär-leucin durch transaminierung
JPS63304986A (ja) 1987-06-04 1988-12-13 Daicel Chem Ind Ltd プラスミド
JPH0787778B2 (ja) 1987-12-10 1995-09-27 田辺製薬株式会社 新規微生物及びそれを用いるｌ−アミノ酸の製法
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US4950606A (en) * 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US6197558B1 (en) 1997-05-19 2001-03-06 Nsc Technologies Transaminase biotransformation process
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
SK284352B6 (sk) * 1998-03-11 2005-02-04 Celgro Spôsob enzymatickej syntézy chirálnych amínov
DE19919848A1 (de) * 1999-04-30 2000-11-02 Aventis Cropscience Gmbh Verfahren zur Herstellung von L-Phosphinothricin durch enzymatische Transaminierung mit Aspartat
JP4280494B2 (ja) * 2000-10-06 2009-06-17 エルスワース バイオテクノロジー リミテッド エタノール産生
US6576794B2 (en) * 2000-12-28 2003-06-10 Kao Corporation Process for production of ether amine
TWI324181B (en) * 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
AU2003223755B2 (en) 2002-04-29 2008-08-21 Merck Sharp & Dohme Corp. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
EP1546096B1 (en) * 2002-08-01 2006-09-06 Basilea Pharmaceutica AG Process for the preparation of amino-pyrrolidine derivatives
EP1756291B1 (en) 2004-04-27 2010-07-07 Archer-Daniels-Midland Company Enzymatic decarboxylation of 2-keto-l-gulonic acid to produce xylose
WO2006126498A1 (ja) * 2005-05-23 2006-11-30 Kaneka Corporation 新規アミノ基転移酵素、およびこれをコードする遺伝子、ならびにこれらの利用法
EP1818411A1 (en) * 2006-02-13 2007-08-15 Lonza AG Process for the preparation of optically active chiral amines
EP1897956A1 (en) * 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase

Also Published As

Publication number Publication date
CN101384723A (zh) 2009-03-11
WO2007093372A1 (en) 2007-08-23
EP1987152A1 (en) 2008-11-05
KR101294499B1 (ko) 2013-08-07
EP2202317A1 (en) 2010-06-30
DE602007006765D1 (de) 2010-07-08
MX2008010416A (es) 2009-01-27
US20150284752A1 (en) 2015-10-08
EP1818411A1 (en) 2007-08-15
EP2202318B1 (en) 2019-11-27
EP2202317B1 (en) 2017-03-01
JP5430945B2 (ja) 2014-03-05
AU2007214717A1 (en) 2007-08-23
EA017070B1 (ru) 2012-09-28
IL192637A0 (en) 2009-02-11
JP2009526531A (ja) 2009-07-23
IL219164A0 (en) 2012-06-28
BRPI0707454A2 (pt) 2011-05-03
US9551018B2 (en) 2017-01-24
ES2345734T3 (es) 2010-09-30
AU2007214717B2 (en) 2011-12-22
ES2626645T3 (es) 2017-07-25
US9074228B2 (en) 2015-07-07
DK1987152T3 (da) 2010-08-30
ATE469233T1 (de) 2010-06-15
ES2767898T3 (es) 2020-06-18
IL219163A0 (en) 2012-06-28
JP2013188217A (ja) 2013-09-26
US20090246837A1 (en) 2009-10-01
CA2637821A1 (en) 2007-08-23
CN101384723B (zh) 2013-03-27
KR20080093437A (ko) 2008-10-21
EP1987152B1 (en) 2010-05-26
PT1987152E (pt) 2010-08-18
EP2202318A1 (en) 2010-06-30
IL192637A (en) 2014-12-31

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