ATE469233T1 - Herstellungsverfahren für optisch aktive chirale amine - Google Patents

Herstellungsverfahren für optisch aktive chirale amine

Info

Publication number
ATE469233T1
ATE469233T1 AT07711521T AT07711521T ATE469233T1 AT E469233 T1 ATE469233 T1 AT E469233T1 AT 07711521 T AT07711521 T AT 07711521T AT 07711521 T AT07711521 T AT 07711521T AT E469233 T1 ATE469233 T1 AT E469233T1
Authority
AT
Austria
Prior art keywords
production process
optically active
chiral amine
active chiral
amine
Prior art date
Application number
AT07711521T
Other languages
English (en)
Inventor
Karen Robins
Uwe Bornscheuer
Matthias Hoehne
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of ATE469233T1 publication Critical patent/ATE469233T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT07711521T 2006-02-13 2007-02-13 Herstellungsverfahren für optisch aktive chirale amine ATE469233T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06002859A EP1818411A1 (de) 2006-02-13 2006-02-13 Verfahren zur Herstellung von optisch aktiven chiralen Aminen
PCT/EP2007/001222 WO2007093372A1 (en) 2006-02-13 2007-02-13 Process for the preparation of optically active chiral amines

Publications (1)

Publication Number Publication Date
ATE469233T1 true ATE469233T1 (de) 2010-06-15

Family

ID=36686005

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07711521T ATE469233T1 (de) 2006-02-13 2007-02-13 Herstellungsverfahren für optisch aktive chirale amine

Country Status (17)

Country Link
US (2) US9074228B2 (de)
EP (4) EP1818411A1 (de)
JP (2) JP5430945B2 (de)
KR (1) KR101294499B1 (de)
CN (1) CN101384723B (de)
AT (1) ATE469233T1 (de)
AU (1) AU2007214717B2 (de)
BR (1) BRPI0707454A2 (de)
CA (1) CA2637821A1 (de)
DE (1) DE602007006765D1 (de)
DK (1) DK1987152T3 (de)
EA (1) EA017070B1 (de)
ES (3) ES2626645T3 (de)
IL (3) IL192637A (de)
MX (1) MX2008010416A (de)
PT (1) PT1987152E (de)
WO (1) WO2007093372A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1818411A1 (de) * 2006-02-13 2007-08-15 Lonza AG Verfahren zur Herstellung von optisch aktiven chiralen Aminen
WO2007139055A1 (ja) * 2006-05-29 2007-12-06 Kaneka Corporation 光学活性アミン化合物の製造方法、組換えベクター、及び該ベクターを含む形質転換体。
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
DE102007042600A1 (de) * 2007-09-07 2009-03-12 Evonik Degussa Gmbh Verfahren zur Herstellung von enantiomerenangereichten Aminen
DE102007060705A1 (de) * 2007-12-17 2009-06-18 Evonik Degussa Gmbh ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen
ES2610130T3 (es) 2007-12-27 2017-04-26 Infinity Pharmaceuticals, Inc. Métodos para reducción estereoselectiva
CN102341494B (zh) 2009-01-08 2014-10-15 科德克希思公司 转氨酶多肽
JP5707344B2 (ja) * 2009-02-26 2015-04-30 コデクシス， インコーポレイテッド トランスアミナーゼ生体触媒
EP2412704A4 (de) 2009-03-23 2015-04-15 Aminologics Co Ltd Verfahren zur gewinnung von optisch reinen aminosäuren
SG177329A1 (en) 2009-06-22 2012-02-28 Codexis Inc Transaminase reactions
ES2567134T3 (es) * 2009-08-05 2016-04-20 Infinity Pharmaceuticals, Inc. Transaminación enzimática de análogos de ciclopamina
MX2012002561A (es) * 2009-09-02 2012-04-10 Lonza Ag Un proceso para la identificacion y preparacion de una omega-transaminasa (r)-especifica.
US8852900B2 (en) 2010-06-17 2014-10-07 Codexis, Inc. Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
US9394313B2 (en) 2010-09-14 2016-07-19 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
JP5936545B2 (ja) 2010-09-28 2016-06-22 株式会社カネカ グルタミン酸に高活性を示す新規アミノ基転移酵素、およびこれをコードする遺伝子、ならびにこれらの利用法
JP5927178B2 (ja) 2011-03-11 2016-06-01 株式会社カネカ 改変型アミノ基転移酵素、その遺伝子、およびそれらを利用した光学活性アミノ化合物の製造方法
KR101479718B1 (ko) 2012-07-06 2015-01-08 연세대학교 산학협력단 오메가 트랜스아미나아제의 조기질 순환을 이용한 광학 활성 아미노산의 제조방법
EP2909327A1 (de) * 2012-10-18 2015-08-26 Sandoz AG Verfahren zur herstellung von indolinderivaten
WO2014092496A1 (ko) * 2012-12-13 2014-06-19 연세대학교 산학협력단 탈라세믹화를 이용한 광학 활성 아민 화합물의 제조방법
KR101493311B1 (ko) * 2012-12-13 2015-02-16 연세대학교 산학협력단 광학 활성 아민 및 호모알라닌의 제조방법
KR101479717B1 (ko) * 2013-02-27 2015-01-08 연세대학교 산학협력단 트랜스아미나제를 이용한 광학활성 알킬아민과 아릴알킬아민의 동시생산방법
ES2734579T3 (es) * 2013-11-26 2019-12-10 Asymchem Lab Tianjin Co Ltd Transaminasa y utilización de la misma
CN103865964A (zh) * 2014-03-14 2014-06-18 上海朴颐化学科技有限公司 转氨酶法合成(r)-3-氨基哌啶的方法
JP6796638B2 (ja) 2015-06-04 2020-12-09 ペレファーム, インク.Pellepharm, Inc. ヘッジホッグ阻害性化合物の送達のための局所的製剤及びその使用
CN105112468B (zh) * 2015-10-14 2019-01-08 厦门大学 一种多酶耦联体系制备手性胺的方法
CN105200089B (zh) * 2015-10-15 2018-09-11 江苏暨明医药科技有限公司 (s)-1-叔丁氧羰基-3-羟基哌啶制备方法及其装置
AU2017227553B2 (en) 2016-03-02 2021-03-25 Basf Se Methods for making L-glufosinate
CN106676142B (zh) * 2016-11-01 2021-01-22 凯莱英医药集团（天津）股份有限公司 一种手性氨基杂环化合物及其衍生物的制备方法
JPWO2018207888A1 (ja) * 2017-05-10 2020-03-12 株式会社カネカ ラメルテオンの製造法
CN107805648B (zh) * 2017-10-10 2020-09-11 凯莱英生命科学技术(天津)有限公司 制备具有多个手性中心的胺化合物的方法
CN112739822A (zh) 2018-09-05 2021-04-30 巴斯夫欧洲公司 改善l-草胺膦产率的方法
CN109370998B (zh) * 2018-11-30 2020-08-04 江南大学 一种催化效率提高的ω-转氨酶突变体I215F
CN110724675B (zh) * 2019-10-31 2021-02-02 宁波酶赛生物工程有限公司 转氨酶催化剂和酶法合成(r)-1-叔丁氧羰基-3-氨基哌啶的方法
CN112626142B (zh) * 2020-12-17 2022-10-18 永农生物科学有限公司 利用生物多酶偶联法制备l-草铵膦的方法
CN112410383B (zh) * 2020-12-17 2022-07-12 永农生物科学有限公司 利用生物多酶偶联法制备l-草铵膦的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3482982D1 (de) 1983-09-01 1990-09-20 Genetics Inst Herstellung von l-aminosaeuren durch transaminierung.
ES2058076T3 (es) 1986-06-04 1994-11-01 Hoechst Ag Procedimiento para la obtencion de l-fosfinotricina por transaminacion.
JPS63304986A (ja) 1987-06-04 1988-12-13 Daicel Chem Ind Ltd プラスミド
JPH0787778B2 (ja) 1987-12-10 1995-09-27 田辺製薬株式会社 新規微生物及びそれを用いるｌ−アミノ酸の製法
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US4950606A (en) * 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US6197558B1 (en) * 1997-05-19 2001-03-06 Nsc Technologies Transaminase biotransformation process
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
CA2322605A1 (en) * 1998-03-11 1999-09-16 Celgro Improvements in the enzymatic synthesis of chiral amines
DE19919848A1 (de) * 1999-04-30 2000-11-02 Aventis Cropscience Gmbh Verfahren zur Herstellung von L-Phosphinothricin durch enzymatische Transaminierung mit Aspartat
BR0114477A (pt) 2000-10-06 2004-01-13 Elsworth Biotech Ltd Produção de etanol
US6576794B2 (en) * 2000-12-28 2003-06-10 Kao Corporation Process for production of ether amine
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
WO2003093231A2 (en) 2002-04-29 2003-11-13 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
AU2003258536C1 (en) * 2002-08-01 2009-12-17 Basilea Pharmaceutica Ag Process for the preparation of amino-pyrrolidine derivatives
CA2564678C (en) * 2004-04-27 2014-09-02 Archer-Daniels-Midland Company Enzymatic decarboxylation of 2-keto-l-gulonic acid to produce xylose
DE602006008934D1 (de) * 2005-05-23 2009-10-15 Kaneka Corp Neue aminogruppentransferase, dafür codierendes gen und verfahren zur verwendung davon
EP1818411A1 (de) * 2006-02-13 2007-08-15 Lonza AG Verfahren zur Herstellung von optisch aktiven chiralen Aminen
EP1897956A1 (de) * 2006-09-06 2008-03-12 Lonza AG Verfahren zur Herstellung von optisch aktiven Aminen durch Racematspaltung unter Verwendung einer bakteriellen omega-Transaminase

Also Published As

Publication number Publication date
IL192637A (en) 2014-12-31
IL192637A0 (en) 2009-02-11
ES2626645T3 (es) 2017-07-25
EA017070B1 (ru) 2012-09-28
MX2008010416A (es) 2009-01-27
AU2007214717B2 (en) 2011-12-22
EP2202318A1 (de) 2010-06-30
JP2013188217A (ja) 2013-09-26
JP5430945B2 (ja) 2014-03-05
BRPI0707454A2 (pt) 2011-05-03
CA2637821A1 (en) 2007-08-23
US20090246837A1 (en) 2009-10-01
WO2007093372A1 (en) 2007-08-23
CN101384723A (zh) 2009-03-11
JP2009526531A (ja) 2009-07-23
DE602007006765D1 (de) 2010-07-08
KR20080093437A (ko) 2008-10-21
DK1987152T3 (da) 2010-08-30
ES2345734T3 (es) 2010-09-30
EP2202317A1 (de) 2010-06-30
AU2007214717A1 (en) 2007-08-23
PT1987152E (pt) 2010-08-18
US9551018B2 (en) 2017-01-24
KR101294499B1 (ko) 2013-08-07
US9074228B2 (en) 2015-07-07
EA200870262A1 (ru) 2009-02-27
CN101384723B (zh) 2013-03-27
EP1987152A1 (de) 2008-11-05
US20150284752A1 (en) 2015-10-08
EP2202317B1 (de) 2017-03-01
EP2202318B1 (de) 2019-11-27
ES2767898T3 (es) 2020-06-18
IL219163A0 (en) 2012-06-28
EP1987152B1 (de) 2010-05-26
EP1818411A1 (de) 2007-08-15
IL219164A0 (en) 2012-06-28

Similar Documents

Publication Publication Date Title
ATE469233T1 (de) Herstellungsverfahren für optisch aktive chirale amine
EA200970247A1 (ru) Способ получения оптического активного n-защищенного 3-аминопирролидина или оптически активного n-защищенного 3-аминопиперидина и соответствующих кетонов путем оптического разделения рацемических смесей аминов с использованием бактериальной омега-трансаминазы
BRPI0914042A2 (pt) processo para a produção de uma ou mais etilenoaminas por uma reação de transaminação
BR112012032244A2 (pt) processo para preparar derivados de antranilamida com tetrazole-substituído e polimorfos cristalinos novos e derivados destes
MY146084A (en) Benzyl amines, a process for their production and their use as anti-inflammatory agents
ATE552256T1 (de) Neuartige form von tiotropium-bromid und herstellungsverfahren dafür
BR112012028395A2 (pt) processo para preparar ditiina-tetracarboxi-diimidas
EA201100727A1 (ru) Новый способ получения производных аминокислот
BR112013002925A2 (pt) processo para a síntese de ácido 2,5-furandicarboxílico
IL181462A0 (en) Process for production of optically active amine derivatives
BRPI0816911A8 (pt) Processo para preparação de 4-aminobut-2-enolidas
CR20110286A (es) Proceso para la preparacion de derivados de l-alanina protegidos
CL2009001684A1 (es) Procedimiento de sintesis de agomelatina por reduccion de un grupo nitrilo en presencia de anhidrido acetico.
UA94837C2 (ru) Способ синтеза (7-метокси-1-нафтил)ацетонитрила и применение в синтезе агомелатина
MX2009008196A (es) Nuevo procedimiento de sintesis de la agomelatina.
TN2010000219A1 (en) 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1h-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
CO6331461A2 (es) Proceso de preparacion de derivados del acido 1-(2-halobifenil-4-il)-ciclopropanocarboxilico
BRPI0909327A2 (pt) Processo para a produção de gás de síntese
FR2969604B1 (fr) Procede de preparation d'acides amines chiraux
UY32349A (es) Derivados de biaril-bencil-amina
BRPI0909171B8 (pt) comprimidos aperfeiçoados contendo isomalte e processo para sua produção
MY158919A (en) Method for resolution of a mixture of pinocembrin optical isomers especially a pinocembrin racemate
TW200621691A (en) Chiral 3-halophthalic acid derivatives
MX2011009731A (es) Nuevo procedimiento de preparacion de compuestos de enaminocarbonilo.
EP2246356A4 (de) Verfahren zur herstellung optisch aktiver amine

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties