EA201100727A1 - Новый способ получения производных аминокислот - Google Patents

Новый способ получения производных аминокислот

Info

Publication number
EA201100727A1
EA201100727A1 EA201100727A EA201100727A EA201100727A1 EA 201100727 A1 EA201100727 A1 EA 201100727A1 EA 201100727 A EA201100727 A EA 201100727A EA 201100727 A EA201100727 A EA 201100727A EA 201100727 A1 EA201100727 A1 EA 201100727A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amino acid
acid derivatives
new method
methoxypropionamide
acetamido
Prior art date
Application number
EA201100727A
Other languages
English (en)
Other versions
EA019040B1 (ru
Inventor
Дидье Буви
Ален Мерсарт
Вероник Пинилла
Йёрг Хаманн
Ральф Канцлер
Антуан Томас
Original Assignee
Юсб Фарма Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40627087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201100727(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Юсб Фарма Гмбх filed Critical Юсб Фарма Гмбх
Publication of EA201100727A1 publication Critical patent/EA201100727A1/ru
Publication of EA019040B1 publication Critical patent/EA019040B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В заявке описан альтернативный способ получения аминопроизводных. В частности, в заявке описан улучшенный способ получения лакозамида (ЛКА), (R)-2-ацетамидо-N-бензил-3-метоксипропионамида, который применим в качестве спазмолитического лекарственного средства. Предпочтительным объектом настоящего изобретения является способ получения оптически обогащенного (R)-2-ацетамидо-N-бензил-3-метоксипропионамида (I), включающий разделение 2-ацетамидо-N-бензил-3-метоксипропионамида (II).
EA201100727A 2008-11-07 2009-11-06 Новый способ получения производных аминокислот EA019040B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08105749 2008-11-07
PCT/EP2009/007962 WO2010052011A1 (en) 2008-11-07 2009-11-06 Novel process for the preparation of amino acid derivatives

Publications (2)

Publication Number Publication Date
EA201100727A1 true EA201100727A1 (ru) 2011-12-30
EA019040B1 EA019040B1 (ru) 2013-12-30

Family

ID=40627087

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100727A EA019040B1 (ru) 2008-11-07 2009-11-06 Новый способ получения производных аминокислот

Country Status (21)

Country Link
US (1) US8946476B2 (ru)
EP (1) EP2352721B1 (ru)
JP (3) JP5986380B2 (ru)
KR (1) KR101755548B1 (ru)
CN (2) CN104058991B (ru)
AU (1) AU2009313037B2 (ru)
BR (1) BRPI0921408B8 (ru)
CA (1) CA2739741C (ru)
CY (1) CY1114053T1 (ru)
DK (1) DK2352721T3 (ru)
EA (1) EA019040B1 (ru)
ES (1) ES2408208T3 (ru)
HK (1) HK1158617A1 (ru)
HR (1) HRP20130456T1 (ru)
IL (1) IL211987A (ru)
ME (1) ME01618B (ru)
MX (1) MX2011004324A (ru)
PL (1) PL2352721T3 (ru)
PT (1) PT2352721E (ru)
SI (1) SI2352721T1 (ru)
WO (1) WO2010052011A1 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101466390B (zh) * 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
WO2011015617A1 (en) 2009-08-06 2011-02-10 Medichem, S.A. Solid forms of an n-(phenylmethyl)propanamide derivative and processes of preparation
IT1398044B1 (it) * 2010-01-29 2013-02-07 Archimica Srl Processo per la preparazione della lacosamide
WO2011158194A1 (en) 2010-06-15 2011-12-22 Medichem, S.A. Enzymatic resolution of racemic (2r,s)-2-(acetylamino)-3-methoxy-n-(phenylmethyl)propanamide
EP2399901A1 (en) 2010-06-23 2011-12-28 Archimica GmbH Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide
US8957252B2 (en) 2010-07-27 2015-02-17 Indoco Remedies Limited Process for preparation of lacosamide and some N-benzyl-propanamide intermediate derivatives
US8969620B2 (en) 2010-10-01 2015-03-03 Ucb Pharma Gmbh Process for the preparation of amino acid derivatives
WO2012046245A1 (en) * 2010-10-05 2012-04-12 Hetero Research Foundation Novel polymorph of lacosamide
EP2444390B1 (en) 2010-10-19 2017-02-01 Euticals GmbH Process for producing Lacosamide
EP2487152A1 (en) 2010-11-17 2012-08-15 UCB Pharma GmbH Process for the preparation of Lacosamide including resolution of O-methyl-DL-serine
GB201020026D0 (en) 2010-11-25 2011-01-12 Cambrex Karlskoga Ab New process
EP2522647B1 (en) * 2011-05-10 2014-04-30 DSM IP Assets B.V. Process of separating chiral isomers of chroman compounds and their derivatives and precursors
EP2776388A4 (en) 2011-11-10 2015-07-08 Davuluri Ramamohan Rao AN INEDIC PROCESS FOR THE PREPARATION OF (R) -N-BENZYL-2-ACETAMIDO-3-METHOXYPROPIONAMIDE
US8779355B2 (en) 2011-12-28 2014-07-15 Quest Diagnostics Investments, Inc. Methods for detecting lacosamide by mass spectrometry
GB201219627D0 (en) * 2012-11-01 2012-12-12 Cambrex Karlskoga Ab New process
KR101578979B1 (ko) * 2013-11-08 2015-12-18 에스티팜 주식회사 라코사마이드의 제조방법
CN104030943B (zh) * 2014-03-12 2016-08-24 重庆福安药业(集团)股份有限公司 一种拉科酰胺的制备方法
WO2016021711A1 (ja) * 2014-08-07 2016-02-11 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法
AU2015308035B2 (en) 2014-08-28 2019-04-04 RAO, Davuluri Ramamohan Improved process for the preparation of Lacosamide and its novel intermediate
CN104892461B (zh) * 2015-06-24 2017-04-19 上海上药第一生化药业有限公司 一种拉科酰胺类似物及其制备方法
JP6905937B2 (ja) * 2015-11-13 2021-07-21 株式会社エーピーアイ コーポレーション ラコサミド及びその中間体の製造方法
CN106811492B (zh) * 2017-01-18 2019-11-01 长兴制药股份有限公司 一种拉科酰胺的制备方法
JP7077221B2 (ja) 2017-03-01 2022-05-30 株式会社エーピーアイ コーポレーション Ｎ－ベンジル－２－ブロモ－３－メトキシプロピオン酸アミド及びその中間体の製造方法
EP3725769A1 (en) * 2019-04-17 2020-10-21 Newron Pharmaceuticals S.p.A. Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives
CN112574058B (zh) * 2020-12-31 2023-04-28 珠海润都制药股份有限公司 一种拉考沙胺的合成路线

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61197530A (ja) * 1985-02-25 1986-09-01 Mitsubishi Gas Chem Co Inc ラセミ化法
US5773475A (en) * 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
JP2001288153A (ja) * 2000-04-06 2001-10-16 Mitsubishi Rayon Co Ltd 光学活性アミノ酸アミドのラセミ化法
GB0325055D0 (en) * 2003-10-27 2003-12-03 Smithkline Beecham Corp New process
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
CN101282940B (zh) * 2005-12-20 2013-02-13 Nps制药公司 含氟化合物
CN101130504B (zh) * 2006-08-25 2010-07-28 苏州雅本化学股份有限公司 经合成、拆分与消旋化制备手性药物左乙拉西坦中间体(s)-(+)-2-氨基丁酰胺盐酸盐的方法
CN100491365C (zh) * 2006-12-08 2009-05-27 浙江大学 外消旋化回收6-氟-3,4-二氢-2h-1-苯并吡喃-2-甲酸的方法

Also Published As

Publication number Publication date
EP2352721B1 (en) 2013-03-27
US8946476B2 (en) 2015-02-03
CY1114053T1 (el) 2016-07-27
IL211987A (en) 2014-04-30
ME01618B (me) 2014-09-20
MX2011004324A (es) 2011-09-21
AU2009313037B2 (en) 2015-07-16
EA019040B1 (ru) 2013-12-30
BRPI0921408B1 (pt) 2020-12-15
CN102209707B (zh) 2014-07-09
JP2012508162A (ja) 2012-04-05
CN104058991B (zh) 2017-04-12
AU2009313037A1 (en) 2010-05-14
PL2352721T3 (pl) 2013-08-30
CN102209707A (zh) 2011-10-05
JP5986380B2 (ja) 2016-09-06
JP6272409B2 (ja) 2018-01-31
ES2408208T3 (es) 2013-06-19
KR101755548B1 (ko) 2017-07-07
HK1158617A1 (en) 2012-07-20
SI2352721T1 (sl) 2013-07-31
EP2352721A1 (en) 2011-08-10
CA2739741A1 (en) 2010-05-14
BRPI0921408A2 (pt) 2016-01-05
JP6272250B2 (ja) 2018-01-31
IL211987A0 (en) 2011-06-30
BRPI0921408B8 (pt) 2021-05-25
HRP20130456T1 (en) 2013-06-30
WO2010052011A1 (en) 2010-05-14
DK2352721T3 (da) 2013-07-01
JP2015091886A (ja) 2015-05-14
CA2739741C (en) 2016-10-11
KR20110086128A (ko) 2011-07-27
PT2352721E (pt) 2013-05-31
CN104058991A (zh) 2014-09-24
JP2016188245A (ja) 2016-11-04
US20110263899A1 (en) 2011-10-27

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Designated state(s): AM AZ BY KZ KG MD TJ TM