EA201300440A1 - Способ получения (3s,3s') 4,4'-дисульфандиилбис(3-аминобутан-1-сульфокислоты) - Google Patents

Способ получения (3s,3s') 4,4'-дисульфандиилбис(3-аминобутан-1-сульфокислоты)

Info

Publication number
EA201300440A1
EA201300440A1 EA201300440A EA201300440A EA201300440A1 EA 201300440 A1 EA201300440 A1 EA 201300440A1 EA 201300440 A EA201300440 A EA 201300440A EA 201300440 A EA201300440 A EA 201300440A EA 201300440 A1 EA201300440 A1 EA 201300440A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disulfandyilbis
aminobutan
obtaining
sulphate
acids
Prior art date
Application number
EA201300440A
Other languages
English (en)
Other versions
EA021612B1 (ru
Inventor
Фабрис Балавуан
Джонатан Мадек
Жан-Мари Шнайдер
Жерар Кокрель
Никола Кувра
Йохан Кртиньи
Мари-Ноэль Пти
Original Assignee
Квантум Дженомикс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Квантум Дженомикс filed Critical Квантум Дженомикс
Publication of EA201300440A1 publication Critical patent/EA201300440A1/ru
Publication of EA021612B1 publication Critical patent/EA021612B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/14—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к новому способу получения (3S,3S') 4,4'-дисульфандиилбис(3-аминобутан-1-сульфокислоты) в пять стадий из (S)-этил 2-(бензилоксикарбониламино)-4-(неопентилоксисульфонил)бутаноата А.
EA201300440A 2010-10-07 2011-10-07 Способ получения (3s,3s') 4,4'-дисульфандиилбис(3-аминобутан-1-сульфокислоты) EA021612B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10306099A EP2439192A1 (en) 2010-10-07 2010-10-07 Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid)
PCT/EP2011/067524 WO2012045849A1 (en) 2010-10-07 2011-10-07 Method for the preparation of (3s,3s') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid)

Publications (2)

Publication Number Publication Date
EA201300440A1 true EA201300440A1 (ru) 2013-08-30
EA021612B1 EA021612B1 (ru) 2015-07-30

Family

ID=43558332

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300440A EA021612B1 (ru) 2010-10-07 2011-10-07 Способ получения (3s,3s') 4,4'-дисульфандиилбис(3-аминобутан-1-сульфокислоты)

Country Status (25)

Country Link
US (2) US9187418B2 (ru)
EP (3) EP2439192A1 (ru)
JP (1) JP5921556B2 (ru)
KR (2) KR101869366B1 (ru)
CN (1) CN103228624B (ru)
AR (1) AR083360A1 (ru)
AU (1) AU2011311483B2 (ru)
BR (2) BR112013008404B1 (ru)
CA (2) CA3016057C (ru)
CY (2) CY1120859T1 (ru)
DK (2) DK3395796T3 (ru)
EA (1) EA021612B1 (ru)
ES (2) ES2689246T3 (ru)
HR (2) HRP20220031T1 (ru)
HU (2) HUE058031T2 (ru)
IL (1) IL225557A (ru)
LT (2) LT2625163T (ru)
MX (1) MX2013003863A (ru)
NZ (1) NZ608971A (ru)
PL (2) PL3395796T3 (ru)
PT (2) PT2625163T (ru)
RS (2) RS57670B1 (ru)
SI (2) SI2625163T1 (ru)
TW (1) TWI532710B (ru)
WO (1) WO2012045849A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2439192A1 (en) 2010-10-07 2012-04-11 Quantum Genomics Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid)
EP2722327A1 (en) * 2012-10-22 2014-04-23 Quantum Genomics Crystalline phase of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) with L-lysine
US10501426B1 (en) 2019-01-11 2019-12-10 King Saud University Synthesis of thiazole derivative as anticancer and anti-antibiotics resistant bacteria agent
TW202100146A (zh) 2019-03-11 2021-01-01 法商量子基因科技有限公司 用於治療高血壓或心衰竭的化合物及包含其之組成物
CN111892557B (zh) * 2019-05-05 2022-11-08 河北圣泰材料股份有限公司 哌嗪类成膜离子液体的合成方法
WO2022225712A1 (en) * 2021-04-22 2022-10-27 Teva Pharmaceuticals International Gmbh Solid state forms of firibastat and processes for preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596095A (en) * 1994-12-12 1997-01-21 Procept, Inc. Formation and utility of sulfonic acid protecting groups
ES2309336T3 (es) * 2002-07-16 2008-12-16 Institut National De La Sante Et De La Recherche Medicale (Inserm) Derivados de 4,4-ditiobis-(3-aminobutano-1-sulfanatos) nuevos y composiciones que los contienen.
FR2858617A1 (fr) * 2003-08-06 2005-02-11 Inst Nat Sante Rech Med Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant
CN101845003A (zh) * 2010-01-29 2010-09-29 华东理工大学 N-三(羟甲基)甲基-3-氨基丙磺酸化合物及其制备方法
EP2439192A1 (en) 2010-10-07 2012-04-11 Quantum Genomics Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid)

Also Published As

Publication number Publication date
HRP20181437T1 (hr) 2018-12-14
IL225557A0 (en) 2013-06-27
HUE040484T2 (hu) 2019-03-28
RS57670B1 (sr) 2018-11-30
CA3016057A1 (en) 2012-04-12
HUE058031T2 (hu) 2022-06-28
US9340497B2 (en) 2016-05-17
PL2625163T3 (pl) 2018-12-31
SI2625163T1 (sl) 2018-11-30
DK3395796T3 (da) 2022-01-17
AU2011311483B2 (en) 2016-03-31
EP2625163B1 (en) 2018-08-15
RS62838B1 (sr) 2022-02-28
AU2011311483A1 (en) 2013-05-02
DK2625163T3 (en) 2018-10-15
EA021612B1 (ru) 2015-07-30
CN103228624B (zh) 2016-02-03
KR20130116268A (ko) 2013-10-23
LT3395796T (lt) 2022-01-25
PL3395796T3 (pl) 2022-03-07
LT2625163T (lt) 2019-01-10
CA2813834A1 (en) 2012-04-12
US9187418B2 (en) 2015-11-17
SI3395796T1 (sl) 2022-03-31
JP5921556B2 (ja) 2016-05-24
BR112013008404A2 (pt) 2016-06-21
BR122021023430B1 (pt) 2022-08-09
EP3395796A1 (en) 2018-10-31
PT2625163T (pt) 2018-10-29
BR112013008404B1 (pt) 2022-02-01
CY1124919T1 (el) 2023-01-05
HRP20220031T1 (hr) 2022-04-01
US20160046571A1 (en) 2016-02-18
US20130231500A1 (en) 2013-09-05
TWI532710B (zh) 2016-05-11
JP2014500238A (ja) 2014-01-09
PT3395796T (pt) 2022-01-13
EP2439192A1 (en) 2012-04-11
CN103228624A (zh) 2013-07-31
WO2012045849A1 (en) 2012-04-12
EP3395796B1 (en) 2021-11-24
NZ608971A (en) 2014-06-27
CA2813834C (en) 2019-02-26
KR101893894B1 (ko) 2018-08-31
CY1120859T1 (el) 2019-12-11
CA3016057C (en) 2020-06-02
EP2625163A1 (en) 2013-08-14
TW201305091A (zh) 2013-02-01
MX2013003863A (es) 2013-08-01
ES2903434T3 (es) 2022-04-01
IL225557A (en) 2016-03-31
AR083360A1 (es) 2013-02-21
ES2689246T3 (es) 2018-11-12
KR101869366B1 (ko) 2018-06-21
KR20180032682A (ko) 2018-03-30

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