EA201001444A1 - Синтез эфиров или тиоэфиров адипата - Google Patents

Синтез эфиров или тиоэфиров адипата

Info

Publication number
EA201001444A1
EA201001444A1 EA201001444A EA201001444A EA201001444A1 EA 201001444 A1 EA201001444 A1 EA 201001444A1 EA 201001444 A EA201001444 A EA 201001444A EA 201001444 A EA201001444 A EA 201001444A EA 201001444 A1 EA201001444 A1 EA 201001444A1
Authority
EA
Eurasian Patent Office
Prior art keywords
esters
relates
producing
adipate
synthesis
Prior art date
Application number
EA201001444A
Other languages
English (en)
Other versions
EA018381B1 (ru
Inventor
Лиан Ву
Аксель Кристоф Трефцер
Стефаан Мари Андре Де Вильдеман
Марко Александр Ван дер Берг
Original Assignee
ДСМ АйПи АССЕТС Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДСМ АйПи АССЕТС Б.В. filed Critical ДСМ АйПи АССЕТС Б.В.
Publication of EA201001444A1 publication Critical patent/EA201001444A1/ru
Publication of EA018381B1 publication Critical patent/EA018381B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Настоящее изобретение касается способа получения сложных эфиров или тиоэфиров адипата. Изобретение также касается способа получения адипиновой кислоты из данных эфиров или тиоэфиров. Изобретением также предусмотрен ряд способов получения промежуточных соединений для данных эфиров или тиоэфиров. Также изобретение касается способа получения 6-аминокапроновой кислоты (6-АСА), способа получения 5-формилвалериановой кислоты (5-FVA) и способа получения капролактама. Кроме того, изобретение касается клеток хозяина для применения в способах по изобретению.
EA201001444A 2008-03-11 2009-03-11 Синтез эфиров или тиоэфиров адипата EA018381B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08152595 2008-03-11
PCT/NL2009/050115 WO2009113853A2 (en) 2008-03-11 2009-03-11 Adipate (ester or thioester) synthesis

Publications (2)

Publication Number Publication Date
EA201001444A1 true EA201001444A1 (ru) 2011-04-29
EA018381B1 EA018381B1 (ru) 2013-07-30

Family

ID=39771877

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001444A EA018381B1 (ru) 2008-03-11 2009-03-11 Синтез эфиров или тиоэфиров адипата

Country Status (18)

Country Link
US (5) US9096873B2 (ru)
EP (2) EP3346011A1 (ru)
JP (1) JP2011512868A (ru)
CN (3) CN102027125B (ru)
AU (1) AU2009224087B2 (ru)
BR (1) BRPI0908946A2 (ru)
DK (1) DK2252698T3 (ru)
EA (1) EA018381B1 (ru)
ES (1) ES2655710T3 (ru)
HU (1) HUE037878T2 (ru)
LT (1) LT2252698T (ru)
MY (1) MY177321A (ru)
NO (1) NO2252698T3 (ru)
PL (1) PL2252698T3 (ru)
SI (1) SI2252698T1 (ru)
TW (2) TWI461538B (ru)
UA (1) UA106040C2 (ru)
WO (1) WO2009113853A2 (ru)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101978042B (zh) 2008-01-22 2017-03-08 基因组股份公司 利用合成气或其它气态碳源和甲醇的方法和有机体
CA3081506A1 (en) 2008-03-05 2009-09-11 Genomatica, Inc. Long chain alcohol-producing organisms
EP3666899A3 (en) * 2008-03-11 2020-09-02 Genomatica, Inc. Preparation of 6-aminocaproic acid from 5-formylvaleric acid
WO2009151728A2 (en) * 2008-03-27 2009-12-17 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
CN102317464B (zh) 2008-12-12 2014-10-29 塞莱西翁有限公司 从α-酮酸生物合成双官能烷烃
CN102348805A (zh) 2009-03-11 2012-02-08 帝斯曼知识产权资产管理有限公司 己二酸的制备
US8404465B2 (en) 2009-03-11 2013-03-26 Celexion, Llc Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks
KR102302146B1 (ko) 2009-04-30 2021-09-14 게노마티카 인코포레이티드 1,3-부탄다이올 생산 유기체
EP2425006A4 (en) 2009-04-30 2013-01-23 Genomatica Inc ORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL, N-BUTANOL AND ISOBUTANOL
ES2749423T3 (es) 2009-05-07 2020-03-20 Genomatica Inc Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico
DK2462221T3 (en) 2009-08-05 2017-05-22 Genomatica Inc SEMISYNTHETIC TEREPHTHALIC ACID BY MICRO-ORGANISMS PRODUCING MUCONIC ACID
US20110097767A1 (en) 2009-10-23 2011-04-28 Priti Pharkya Microorganisms for the production of aniline
WO2011094131A1 (en) 2010-01-29 2011-08-04 Genomatica, Inc. Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
JP2013542710A (ja) * 2010-04-27 2013-11-28 キベルディ インコーポレイテッド 無機炭素源および／またはｃ１炭素源から有用有機化合物への非光合成炭素の回収および変換のための酸水素微生物の使用
US8895779B2 (en) 2010-04-30 2014-11-25 Bioamber Inc. Processes for producing monoammonium adipate and conversion of monoammonium adipate to adipic acid
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
WO2011143592A1 (en) * 2010-05-13 2011-11-17 Joule Unlimited Technologies, Inc. Methods and compositions for the recombinant biosynthesis of propanol
JP5878524B2 (ja) 2010-06-14 2016-03-08 株式会社アモーレパシフィックＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ 新規土壌微生物、前記土壌微生物から分離された新規な酸化還元酵素、前記酸化還元酵素をコード化する遺伝子、及びこれらを利用した無糖体の生産方法
US20130150551A1 (en) * 2010-06-16 2013-06-13 Bioamber S.A.S. Processes for the production of hydrogenated products and derivatives thereof
EP2582678B1 (en) * 2010-06-16 2016-12-07 BioAmber Inc. Processes for producing caprolactam and derivatives thereof from fermentation broths containing diammonium adipate or monoammonium adipate
JP2013531657A (ja) * 2010-06-16 2013-08-08 ビオアンブ，ソシエテ パ アクシオンス シンプリフィエ 水素化産物とそれらの誘導体の製造方法
EP2582679B1 (en) 2010-06-16 2017-08-02 BioAmber Inc. Processes for producing caprolactam and derivatives thereof from fermentation broths containing diammonium adipate, monoammonium adipate and/or adipic acid
WO2012018624A2 (en) 2010-07-26 2012-02-09 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
US9334514B2 (en) 2010-10-29 2016-05-10 The Regents Of The University Of California Hybrid polyketide synthases
WO2012089613A1 (en) 2010-12-28 2012-07-05 Dsm Ip Assets B.V. Process to increase the production of a succinyl-coa derived compound
US8728798B2 (en) 2011-05-03 2014-05-20 Verdezyne, Inc. Biological methods for preparing adipic acid
CN105969813A (zh) 2011-06-17 2016-09-28 英威达技术有限责任公司 使用水解酶来增加废物流中的单体含量
MY161761A (en) * 2011-06-17 2017-05-15 Invista Tech Sarl Methods of making nylon intermediates from glycerol
BR112013033672A2 (pt) 2011-06-30 2017-03-14 Invista Tech Sarl método para converter um composto, cultura substancialmente pura de células hospedeiras e cèlula isolada
WO2013067432A1 (en) 2011-11-02 2013-05-10 Genomatica, Inc. Microorganisms and methods for the production of caprolactone
US9102958B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
US9102960B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
US8691960B2 (en) 2012-02-29 2014-04-08 Duke University Oxidoreductases for enantioselective reactions
CN103484490B (zh) * 2012-06-12 2015-10-28 中国科学院过程工程研究所 用于生产己二酸的重组质粒、基因工程菌、其制备方法及用途
JP2015531237A (ja) * 2012-10-11 2015-11-02 テクニカル・ユニヴァーシティ・オブ・デンマーク 遺伝子組換え酵母
BR112015013413A2 (pt) 2012-12-14 2017-11-14 Invista Tech Sarl método para biosintetizar um produto e hospedeiro recombinante
CN105026570A (zh) 2012-12-31 2015-11-04 英威达技术有限责任公司 通过氧化裂解从长链脂肪酸生产7-碳化学物的方法
WO2014105797A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation
CN105408487A (zh) 2012-12-31 2016-03-16 英威达技术有限责任公司 通过甲酯保护的碳链延伸生产7碳化学物的方法
WO2014105790A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
CN105008543A (zh) 2012-12-31 2015-10-28 英威达技术有限责任公司 通过芳香族化合物生产7-碳化学物的方法
EP2938731A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
CN105073214A (zh) 2012-12-31 2015-11-18 英威达技术有限责任公司 通过甲酯保护的碳链延伸生产6碳化学物的方法
JP2016521562A (ja) * 2013-06-12 2016-07-25 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション トランスアミナーゼ生体触媒
CN103937841B (zh) * 2014-05-13 2015-10-28 上海交通大学 烯酰辅酶a水合酶在己二酸生物合成中的应用
US9745607B2 (en) 2014-05-15 2017-08-29 Invista North America S.A.R.L. Methods of producing 6-carbon chemicals using 2,6-diaminopimelate as precursor to 2-aminopimelate
EP3155108A1 (en) 2014-06-16 2017-04-19 Invista Technologies S.à.r.l. Methods, reagents and cells for biosynthesizing compounds
BR112016029394A2 (pt) 2014-06-16 2017-10-17 Invista Tech Sarl métodos, reagentes e células para biossintetizar composto
BR112016029382A2 (pt) 2014-06-16 2017-10-17 Invista Tech Sarl processo para a produção de glutarato e éster metílico de ácido glutárico
EP3155107A1 (en) 2014-06-16 2017-04-19 Invista Technologies S.à.r.l. Methods, reagents and cells for biosynthesizing compounds
CN107636157B (zh) * 2015-06-10 2021-10-26 东丽株式会社 3-羟基己二酸的制造方法
BR112017026276A2 (pt) * 2015-06-10 2018-09-11 Toray Industries, Inc. ?método para produção de ácido a-hidromucônico?
WO2016207403A1 (en) * 2015-06-24 2016-12-29 Deinove Method of producing muconic acid
US11291693B2 (en) 2015-06-25 2022-04-05 Synlogic Operating Company, Inc. Bacteria engineered to treat metabolic diseases
EP3348544A4 (en) * 2015-09-11 2019-03-27 Toray Industries, Inc. PROCESS FOR THE PRODUCTION OF CAPROLACTAM
CN109154006A (zh) 2016-03-19 2019-01-04 基沃德股份有限公司 用于从c1底物生产蛋白质，食品和有用副产品的微生物和人工生态系统
MX2018014764A (es) 2016-05-31 2019-04-29 Toray Industries Metodo para producir acido 3-hidroxiadipico.
MX2018014769A (es) 2016-05-31 2019-04-29 Toray Industries Metodo para producir acido a-hidromuconico.
EA201891926A1 (ru) 2017-02-03 2019-04-30 Киверди, Инк. Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1
WO2022181654A1 (ja) * 2021-02-25 2022-09-01 東レ株式会社 変異型アシル－ＣｏＡヒドロラーゼ
KR20230159611A (ko) 2021-03-30 2023-11-21 아사히 가세이 가부시키가이샤 재조합 미생물 및 c6 화합물의 제조 방법
JPWO2022209994A1 (ru) 2021-03-30 2022-10-06
CN113621630B (zh) * 2021-08-05 2023-03-24 昆明理工大学 3-酮脂酰-CoA硫解酶基因RkACAA1-1及其应用
CN113652440B (zh) * 2021-08-05 2023-04-21 昆明理工大学 3-酮脂酰辅酶a硫解酶基因rkacaa1-2及其应用
CN113956334B (zh) * 2021-12-22 2022-03-18 南京市妇幼保健院 一种棕色脂肪细胞分泌肽及其衍生物在肥胖防治中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8707405D0 (en) * 1987-03-27 1987-04-29 Shell Int Research Preparation of diester of adipic acid
AT399149B (de) 1993-06-07 1995-03-27 Chemie Linz Gmbh Verfahren zur herstellung primärer amine aus aldehyden
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
KR100516986B1 (ko) 1997-02-19 2005-09-26 코닌클리즈케 디에스엠 엔.브이. 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법
US6365376B1 (en) 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
US6498242B1 (en) 1999-02-19 2002-12-24 E. I. Du Pont De Nemours And Company Biological method for the production of adipic acid and intermediates
DE19907519A1 (de) * 1999-02-22 2000-08-31 Basf Ag Verfahren zur Herstellung von substituierten Olefinen
JP2001041958A (ja) * 1999-07-28 2001-02-16 Takeda Chem Ind Ltd 環境汚染物質の免疫学的測定分析法
US6372939B1 (en) 2000-11-16 2002-04-16 E.I. Du Pont De Nemours And Company Production of 6-aminocaproic acid
ES2250728T3 (es) * 2001-11-09 2006-04-16 Shell Internationale Research Maatschappij B.V. Ligandos bidentados para la carbonilacion de compuestos insaturados.
TWI289473B (en) 2001-12-12 2007-11-11 Ind Tech Res Inst Novel coordination compound with acid groups and a method for preparing adipic acid/adipate
WO2004106347A1 (en) 2003-05-28 2004-12-09 Dsm Ip Assets B.V. Cephem compound
JP2005015627A (ja) * 2003-06-26 2005-01-20 Jsr Corp 光硬化性液状樹脂組成物
BRPI0506942B1 (pt) * 2004-01-19 2015-07-28 Dsm Ip Assets Bv Síntese bioquímica de ácido 6-amino capróico
WO2007030830A2 (en) 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
BRPI0713795B1 (pt) 2006-06-29 2018-03-20 Dsm Ip Assets B.V. Método de otimização de uma sequência de nucleotídeos codificadora que codifica uma sequência de aminoácidos predeterminada
WO2009151728A2 (en) * 2008-03-27 2009-12-17 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds

Also Published As

Publication number Publication date
TW201525140A (zh) 2015-07-01
AU2009224087B2 (en) 2015-04-16
CN102027125B (zh) 2018-09-18
US20170073708A1 (en) 2017-03-16
NO2252698T3 (ru) 2018-04-21
US10435723B2 (en) 2019-10-08
CN109468348A (zh) 2019-03-15
JP2011512868A (ja) 2011-04-28
SI2252698T1 (en) 2018-04-30
UA106040C2 (ru) 2014-07-25
TWI461538B (zh) 2014-11-21
US11365432B2 (en) 2022-06-21
DK2252698T3 (en) 2018-01-22
HUE037878T2 (hu) 2018-09-28
ES2655710T3 (es) 2018-02-21
US20230022583A1 (en) 2023-01-26
US9096873B2 (en) 2015-08-04
CN116515915A (zh) 2023-08-01
AU2009224087A1 (en) 2009-09-17
CN102027125A (zh) 2011-04-20
TWI567201B (zh) 2017-01-21
CN109468348B (zh) 2023-05-16
US20200239917A1 (en) 2020-07-30
LT2252698T (lt) 2018-02-12
EP2252698B1 (en) 2017-11-22
WO2009113853A3 (en) 2009-11-19
WO2009113853A2 (en) 2009-09-17
BRPI0908946A2 (pt) 2018-02-27
PL2252698T3 (pl) 2018-03-30
EA018381B1 (ru) 2013-07-30
EP2252698A2 (en) 2010-11-24
TW201002824A (en) 2010-01-16
US20110091944A1 (en) 2011-04-21
EP3346011A1 (en) 2018-07-11
US20140178949A1 (en) 2014-06-26
MY177321A (en) 2020-09-11

Similar Documents

Publication Publication Date Title
EA201001444A1 (ru) Синтез эфиров или тиоэфиров адипата
EA201001445A1 (ru) ПОЛУЧЕНИЕ 6-АМИНОКАПРОНОВОЙ КИСЛОТЫ ИЗ α-КЕТОПИМЕЛИНОВОЙ КИСЛОТЫ
ATE517190T1 (de) Verfahren zur fermentativen herstellung von 1,5- diaminopentan
MX2010008553A (es) Procedimiento para la sintesis regioselectiva de derivados de acido 1-alquil-3-haloalquil-pirazol-4-carboxilico.
EA201201476A1 (ru) Синтез кето-эпоксидов аминокислот
WO2009114702A3 (en) Recombinant production of authentic human proteins using human cell expression systems
MY169947A (en) Preparation of 6-aminocaproic acid from 5-formyl valeri c acid
EP2248906A4 (en) PROCESS FOR THE PREPARATION OF L-AMINO ACID
ATE555098T1 (de) Verfahren zur herstellung 1,3-disubstituierter pyrazolcarbonsäureester
EA201100727A1 (ru) Новый способ получения производных аминокислот
ITMI20081164A1 (it) Processo per la produzione di esteri dell'acido levulinico da biomasse
MX2010002463A (es) Plantas con rasgos relacionados con un rendimiento aumentado y un metodo para producirlas.
WO2009028338A1 (ja) 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法
MX2012007868A (es) Metodo para preparar sales de acido tetrazol-mentasulfonico, y un nuevo compuesto utilizado en las mismas.
ATE489352T1 (de) Verfahren zur herstellung von brenztraubensäure
EA201300440A1 (ru) Способ получения (3s,3s') 4,4'-дисульфандиилбис(3-аминобутан-1-сульфокислоты)
WO2009060297A3 (en) An improved process for the preparation of paliperidone and its intermediates
EA200971019A1 (ru) Способы получения (r)-2-метилпирролидина и (s)-2-метилпирролидина и их солей винной кислоты
ATE555093T1 (de) Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung
NZ609370A (en) Synthetic gene for expressing sm-14 in pichia pastoris, methods for producing and purifying sm-14 and the use thereof as a vaccine and diagnostic medium
DE602007010926D1 (de) Neues verfahren zur herstellung von ammoniumsalzen von esomeprazol
EA201171413A1 (ru) Способ получения олмесартана медоксомила
ATE517890T1 (de) Verfahren zur herstellung von reinem irbesartan
ATE519765T1 (de) Verfahren zur herstellung von 3-hydroxymorphinan- derivaten
DE602005007724D1 (de) Verfahren zur halbsynthese von deserpidin

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment