ATE555093T1 - Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung - Google Patents
Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindungInfo
- Publication number
- ATE555093T1 ATE555093T1 AT08707040T AT08707040T ATE555093T1 AT E555093 T1 ATE555093 T1 AT E555093T1 AT 08707040 T AT08707040 T AT 08707040T AT 08707040 T AT08707040 T AT 08707040T AT E555093 T1 ATE555093 T1 AT E555093T1
- Authority
- AT
- Austria
- Prior art keywords
- pipecoloxylidide
- alkyl
- compound
- producing
- levobupivacaine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 229960004288 levobupivacaine Drugs 0.000 abstract 1
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960001549 ropivacaine Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2008/000236 WO2009089841A1 (en) | 2008-01-15 | 2008-01-15 | Process for the preparation of (s)-1-alkyl-2',6'-pipecoloxylidide compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555093T1 true ATE555093T1 (de) | 2012-05-15 |
Family
ID=39485172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08707040T ATE555093T1 (de) | 2008-01-15 | 2008-01-15 | Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2234974B1 (de) |
| AT (1) | ATE555093T1 (de) |
| CY (1) | CY1112979T1 (de) |
| DK (1) | DK2234974T3 (de) |
| ES (1) | ES2383714T3 (de) |
| PL (1) | PL2234974T3 (de) |
| PT (1) | PT2234974E (de) |
| WO (1) | WO2009089841A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103073484B (zh) * | 2013-01-28 | 2014-10-22 | 山东诚创医药技术开发有限公司 | 一种甲哌卡因及其光学对映体的制备方法 |
| WO2017036408A1 (zh) * | 2015-09-01 | 2017-03-09 | 四川海思科制药有限公司 | S-(-)-1-丙基-2',6'-二甲苯胺甲酰基哌啶晶体及其缓释制剂 |
| CN105585520A (zh) * | 2015-12-24 | 2016-05-18 | 山东齐都药业有限公司 | 盐酸左布比卡因a晶型及其制备方法 |
| CN113717094B (zh) * | 2021-08-11 | 2023-05-05 | 山东辰龙药业有限公司 | 一种制备甲哌卡因的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60502054A (ja) * | 1983-08-01 | 1985-11-28 | アストラ・レケメデル・アクチボラグ | Ｌ―Ｎ―ｎ―プロピルピペコリン酸―２，６―キシリダイドおよびその製造方法 |
| SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
| HU227420B1 (en) * | 1994-10-25 | 2011-05-30 | Darwin Discovery Ltd | Produce for resolving of levobupivacaine and its derivates |
| US20090187024A1 (en) * | 2006-04-25 | 2009-07-23 | Dishman Pharmaceuticals And Chemicals Ltd. | Ropivacaine hydrochloride anhydrate and the preparation thereof |
-
2008
- 2008-01-15 WO PCT/EP2008/000236 patent/WO2009089841A1/en not_active Ceased
- 2008-01-15 AT AT08707040T patent/ATE555093T1/de active
- 2008-01-15 EP EP08707040A patent/EP2234974B1/de active Active
- 2008-01-15 PT PT08707040T patent/PT2234974E/pt unknown
- 2008-01-15 PL PL08707040T patent/PL2234974T3/pl unknown
- 2008-01-15 ES ES08707040T patent/ES2383714T3/es active Active
- 2008-01-15 DK DK08707040.5T patent/DK2234974T3/da active
-
2012
- 2012-07-24 CY CY20121100654T patent/CY1112979T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2234974E (pt) | 2012-05-29 |
| PL2234974T3 (pl) | 2012-09-28 |
| CY1112979T1 (el) | 2016-04-13 |
| EP2234974B1 (de) | 2012-04-25 |
| DK2234974T3 (da) | 2012-06-25 |
| EP2234974A1 (de) | 2010-10-06 |
| ES2383714T3 (es) | 2012-06-25 |
| WO2009089841A1 (en) | 2009-07-23 |
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