ATE489367T1 - Verfahren und zwischenprodukt zur herstellung von donezepil - Google Patents
Verfahren und zwischenprodukt zur herstellung von donezepilInfo
- Publication number
- ATE489367T1 ATE489367T1 AT07700316T AT07700316T ATE489367T1 AT E489367 T1 ATE489367 T1 AT E489367T1 AT 07700316 T AT07700316 T AT 07700316T AT 07700316 T AT07700316 T AT 07700316T AT E489367 T1 ATE489367 T1 AT E489367T1
- Authority
- AT
- Austria
- Prior art keywords
- donezepil
- producing
- intermediate product
- relates
- compounds
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229960003530 donepezil Drugs 0.000 abstract 1
- 229960003135 donepezil hydrochloride Drugs 0.000 abstract 1
- XWAIAVWHZJNZQQ-UHFFFAOYSA-N donepezil hydrochloride Chemical compound [H+].[Cl-].O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 XWAIAVWHZJNZQQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN17MU2006 | 2006-01-04 | ||
| PCT/GB2007/000009 WO2007077443A1 (en) | 2006-01-04 | 2007-01-03 | Process and intermediate for preparation of donepezil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE489367T1 true ATE489367T1 (de) | 2010-12-15 |
Family
ID=37728502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07700316T ATE489367T1 (de) | 2006-01-04 | 2007-01-03 | Verfahren und zwischenprodukt zur herstellung von donezepil |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8030491B2 (de) |
| EP (1) | EP1973878B1 (de) |
| JP (1) | JP2009524599A (de) |
| KR (1) | KR20080085195A (de) |
| AT (1) | ATE489367T1 (de) |
| AU (1) | AU2007203969B2 (de) |
| CA (1) | CA2635550A1 (de) |
| DE (1) | DE602007010725D1 (de) |
| ES (1) | ES2354737T3 (de) |
| NZ (1) | NZ569532A (de) |
| WO (1) | WO2007077443A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080085195A (ko) | 2006-01-04 | 2008-09-23 | 씨아이피엘에이 엘티디. | 도네페질의 제조방법 및 중간체 |
| US20100113793A1 (en) * | 2006-03-20 | 2010-05-06 | Ind-Swift Laboratories Limited | Process for the Preparation of Highly Pure Donepezil |
| EP2114166A4 (de) | 2006-12-11 | 2011-05-25 | Reviva Pharmaceuticals Inc | Zusammensetzungen, synthese und verfahren zur verwendung indanonbasierter cholinesterase-hemmer |
| KR101062073B1 (ko) | 2008-09-04 | 2011-09-02 | 주식회사종근당 | 도네페질, 염산도네페질 및 그의 중간체의 신규 제조방법 |
| EP2366378A1 (de) | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Donepezilformulierungen mit verzögerter Freisetzung |
| WO2012038966A1 (en) | 2010-09-22 | 2012-03-29 | Tyche Industries Ltd. | Process for the preparation of donepezil intermediate |
| CN103524515B (zh) | 2012-07-03 | 2016-07-06 | 浙江海正药业股份有限公司 | 具有乙酰胆碱酯酶抑制活性的苯并间二氧杂环戊烯衍生物及其制备方法和用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| AU716462B2 (en) * | 1995-12-15 | 2000-02-24 | Pfizer Inc. | Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine |
| IL125809A (en) | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
| US20050239837A1 (en) * | 2002-08-14 | 2005-10-27 | Gutman Arie L | Process for production of highly pure donepezil hydrochloride |
| JP4544999B2 (ja) * | 2002-11-25 | 2010-09-15 | 持田製薬株式会社 | ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤 |
| JP2004217639A (ja) * | 2002-12-24 | 2004-08-05 | Eisai Co Ltd | アルツハイマー病治療剤 |
| US6953856B2 (en) * | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
| EP1654230A1 (de) * | 2003-07-01 | 2006-05-10 | Hetero Drugs Limited | Herstellung von zwischenprodukten für acetylcholinesteraseinhibitoren |
| CA2552221A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Donepezil formulations |
| CN1300112C (zh) * | 2004-01-06 | 2007-02-14 | 浙江大学 | N－苄基－4－哌啶基甲醛的合成方法 |
| WO2005076749A2 (en) * | 2004-02-11 | 2005-08-25 | Jubilant Organosys Limited | A novel process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine |
| KR20080085195A (ko) | 2006-01-04 | 2008-09-23 | 씨아이피엘에이 엘티디. | 도네페질의 제조방법 및 중간체 |
-
2007
- 2007-01-03 KR KR1020087018991A patent/KR20080085195A/ko not_active Ceased
- 2007-01-03 WO PCT/GB2007/000009 patent/WO2007077443A1/en not_active Ceased
- 2007-01-03 US US12/159,770 patent/US8030491B2/en not_active Expired - Fee Related
- 2007-01-03 JP JP2008549055A patent/JP2009524599A/ja not_active Ceased
- 2007-01-03 AU AU2007203969A patent/AU2007203969B2/en not_active Ceased
- 2007-01-03 ES ES07700316T patent/ES2354737T3/es active Active
- 2007-01-03 NZ NZ569532A patent/NZ569532A/en not_active IP Right Cessation
- 2007-01-03 EP EP07700316A patent/EP1973878B1/de not_active Not-in-force
- 2007-01-03 DE DE602007010725T patent/DE602007010725D1/de active Active
- 2007-01-03 CA CA002635550A patent/CA2635550A1/en not_active Abandoned
- 2007-01-03 AT AT07700316T patent/ATE489367T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009524599A (ja) | 2009-07-02 |
| US8030491B2 (en) | 2011-10-04 |
| EP1973878B1 (de) | 2010-11-24 |
| NZ569532A (en) | 2010-11-26 |
| DE602007010725D1 (de) | 2011-01-05 |
| AU2007203969A1 (en) | 2007-07-12 |
| WO2007077443A1 (en) | 2007-07-12 |
| KR20080085195A (ko) | 2008-09-23 |
| AU2007203969B2 (en) | 2012-04-05 |
| ES2354737T3 (es) | 2011-03-17 |
| EP1973878A1 (de) | 2008-10-01 |
| CA2635550A1 (en) | 2007-07-12 |
| US20090187020A1 (en) | 2009-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |