UA106595C2 - Спосіб одержання празугрелю - Google Patents

Спосіб одержання празугрелю

Info

Publication number
UA106595C2
UA106595C2 UAA201108002A UAA201108002A UA106595C2 UA 106595 C2 UA106595 C2 UA 106595C2 UA A201108002 A UAA201108002 A UA A201108002A UA A201108002 A UAA201108002 A UA A201108002A UA 106595 C2 UA106595 C2 UA 106595C2
Authority
UA
Ukraine
Prior art keywords
formula
reaction mixture
hydrochloric acid
prodrug
directly
Prior art date
Application number
UAA201108002A
Other languages
English (en)
Inventor
Хана Степанкова
Йосеф Гаїцек
Міхал Доуса
Original Assignee
Зентіва, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентіва, К.С. filed Critical Зентіва, К.С.
Publication of UA106595C2 publication Critical patent/UA106595C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Винахід належить до способу одержання празугрелю, використовуючи метансульфонат 3-циклопропіл-1-(2-фторфеніл)-3-оксопропілу для алкілування 2-оксо-тієнотетрагідропіридину, який може знаходитись у формі солі, наприклад, з хлорводневою кислотою або п-толуолсульфоновою кислотою. Отриману сполуку формули II ацилювали, бажано ацетангідридом, бажано безпосередньо у реакційній суміші без виділення, та одержаний празугрель формули І після цього кристалізували безпосередньо у реакційній суміші.III
UAA201108002A 2008-11-26 2009-11-24 Спосіб одержання празугрелю UA106595C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20080748A CZ2008748A3 (cs) 2008-11-26 2008-11-26 Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c] pyridin-2-yl acetátu, prasugrelu
PCT/CZ2009/000139 WO2010060389A1 (en) 2008-11-26 2009-11-24 A method for the manufacture of highly pure prasugrel

Publications (1)

Publication Number Publication Date
UA106595C2 true UA106595C2 (uk) 2014-09-25

Family

ID=41796198

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201108002A UA106595C2 (uk) 2008-11-26 2009-11-24 Спосіб одержання празугрелю

Country Status (6)

Country Link
US (1) US20110282064A1 (uk)
EP (1) EP2367831A1 (uk)
CZ (1) CZ2008748A3 (uk)
EA (1) EA019169B1 (uk)
UA (1) UA106595C2 (uk)
WO (1) WO2010060389A1 (uk)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103524530A (zh) * 2013-10-24 2014-01-22 广州邦民制药厂有限公司 普拉格雷氢溴酸盐及其制备方法
HU231079B1 (hu) 2016-06-23 2020-06-29 Richter Gedeon Nyrt. Eljárás nagytisztaságú Prasugrel előállítására bromopentil szennyezés eltávolításával
CN112964794B (zh) * 2019-12-13 2022-10-18 武汉武药制药有限公司 一种分离检测4,5,6,7-四氢噻吩[3,2-c]吡啶盐酸盐及其有关物质的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576901B1 (fr) 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FI101150B (fi) 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
JP5844028B2 (ja) * 2006-04-04 2016-01-13 ケージー アクキュイシチオン エルエルシー 抗血小板薬及び酸阻害薬を含む経口剤形
US9158920B2 (en) * 2007-06-28 2015-10-13 Intel Corporation System and method for out-of-band assisted biometric secure boot
CZ302135B6 (cs) * 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
WO2009066326A2 (en) * 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
EP2257556A1 (en) * 2008-02-06 2010-12-08 Helm AG Prasugrel salts with improved properties
CN101402643B (zh) * 2008-11-11 2012-11-28 上海现代制药股份有限公司 一种适于工业生产的普拉格雷的制备方法
CN101402593A (zh) * 2008-11-11 2009-04-08 上海现代制药股份有限公司 用于制备普拉格雷的中间体及其制备方法
CN101402556B (zh) * 2008-11-11 2014-01-29 上海现代制药股份有限公司 新化合物1-环丙基-2-(2-氟苯基)-2-羟基乙酮及其制备方法和用途

Also Published As

Publication number Publication date
EA201100678A1 (ru) 2011-10-31
EP2367831A1 (en) 2011-09-28
CZ2008748A3 (cs) 2010-06-02
EA019169B1 (ru) 2014-01-30
WO2010060389A1 (en) 2010-06-03
US20110282064A1 (en) 2011-11-17

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