PL2234974T3 - Sposób otrzymywania związku (s)-1-alkilo-2', 6'-pipekoloksylidydu - Google Patents

Sposób otrzymywania związku (s)-1-alkilo-2', 6'-pipekoloksylidydu

Info

Publication number
PL2234974T3
PL2234974T3 PL08707040T PL08707040T PL2234974T3 PL 2234974 T3 PL2234974 T3 PL 2234974T3 PL 08707040 T PL08707040 T PL 08707040T PL 08707040 T PL08707040 T PL 08707040T PL 2234974 T3 PL2234974 T3 PL 2234974T3
Authority
PL
Poland
Prior art keywords
pipecoloxylidide
alkyl
compound
preparation
levobupivacaine
Prior art date
Application number
PL08707040T
Other languages
English (en)
Inventor
Theocharis Koftis
Rohit Ravikant Soni
Ionna Georgopoulou
Alexandra Lithadioti
Original Assignee
Pharmathen Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmathen Sa filed Critical Pharmathen Sa
Publication of PL2234974T3 publication Critical patent/PL2234974T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL08707040T 2008-01-15 2008-01-15 Sposób otrzymywania związku (s)-1-alkilo-2', 6'-pipekoloksylidydu PL2234974T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2008/000236 WO2009089841A1 (en) 2008-01-15 2008-01-15 Process for the preparation of (s)-1-alkyl-2',6'-pipecoloxylidide compound
EP08707040A EP2234974B1 (en) 2008-01-15 2008-01-15 Process for the preparation of (s)-1-alkyl-2',6'-pipecoloxylidide compound

Publications (1)

Publication Number Publication Date
PL2234974T3 true PL2234974T3 (pl) 2012-09-28

Family

ID=39485172

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08707040T PL2234974T3 (pl) 2008-01-15 2008-01-15 Sposób otrzymywania związku (s)-1-alkilo-2', 6'-pipekoloksylidydu

Country Status (8)

Country Link
EP (1) EP2234974B1 (pl)
AT (1) ATE555093T1 (pl)
CY (1) CY1112979T1 (pl)
DK (1) DK2234974T3 (pl)
ES (1) ES2383714T3 (pl)
PL (1) PL2234974T3 (pl)
PT (1) PT2234974E (pl)
WO (1) WO2009089841A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103073484B (zh) * 2013-01-28 2014-10-22 山东诚创医药技术开发有限公司 一种甲哌卡因及其光学对映体的制备方法
WO2017036408A1 (zh) * 2015-09-01 2017-03-09 四川海思科制药有限公司 S-(-)-1-丙基-2',6'-二甲苯胺甲酰基哌啶晶体及其缓释制剂
CN105585520A (zh) * 2015-12-24 2016-05-18 山东齐都药业有限公司 盐酸左布比卡因a晶型及其制备方法
CN113717094B (zh) * 2021-08-11 2023-05-05 山东辰龙药业有限公司 一种制备甲哌卡因的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151110B1 (en) * 1983-08-01 1989-03-01 Astra Läkemedel Aktiebolag L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
PT788480E (pt) * 1994-10-25 2003-12-31 Darwin Discovery Ltd Cristalizacao de levobupivacaina e seus analogos
JP2009535327A (ja) * 2006-04-25 2009-10-01 ディシュマン・ファーマシューティカルズ・アンド・ケミカルズ・リミテッド ロピバカイン塩酸塩無水物およびその調製

Also Published As

Publication number Publication date
EP2234974B1 (en) 2012-04-25
EP2234974A1 (en) 2010-10-06
CY1112979T1 (el) 2016-04-13
ATE555093T1 (de) 2012-05-15
WO2009089841A1 (en) 2009-07-23
PT2234974E (pt) 2012-05-29
ES2383714T3 (es) 2012-06-25
DK2234974T3 (da) 2012-06-25

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