WO2008087654A3 - PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 - Google Patents

PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 Download PDF

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Publication number
WO2008087654A3
WO2008087654A3 PCT/IN2008/000007 IN2008000007W WO2008087654A3 WO 2008087654 A3 WO2008087654 A3 WO 2008087654A3 IN 2008000007 W IN2008000007 W IN 2008000007W WO 2008087654 A3 WO2008087654 A3 WO 2008087654A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperidines
inhibitors
hydroxysteroid dehydrogenase
dehydrogenase type
relates
Prior art date
Application number
PCT/IN2008/000007
Other languages
French (fr)
Other versions
WO2008087654A2 (en
Inventor
Rajendra Kharul
Pankaj Ramanbhai Patel
Original Assignee
Cadila Healthcare Ltd
Rajendra Kharul
Pankaj Ramanbhai Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Rajendra Kharul, Pankaj Ramanbhai Patel filed Critical Cadila Healthcare Ltd
Publication of WO2008087654A2 publication Critical patent/WO2008087654A2/en
Publication of WO2008087654A3 publication Critical patent/WO2008087654A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/98—Nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to substituted piperidine compounds of the general formula (I) their tautomeric forms, their stereoisomers, their pharmaceutically accepted salts, or prodrugs thereof. The invention also relates to process for the manufacture of said compounds, and pharmaceutical compositions containing them and their use.
PCT/IN2008/000007 2007-01-16 2008-01-07 PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 WO2008087654A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN79MU2007 2007-01-16
IN79/MUM/2007 2007-01-16

Publications (2)

Publication Number Publication Date
WO2008087654A2 WO2008087654A2 (en) 2008-07-24
WO2008087654A3 true WO2008087654A3 (en) 2008-12-18

Family

ID=39544997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000007 WO2008087654A2 (en) 2007-01-16 2008-01-07 PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1

Country Status (1)

Country Link
WO (1) WO2008087654A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
EP2582709B1 (en) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056745A2 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as 11-beta hydroxysteroid dehydrogenase inhibitors
WO2006094633A1 (en) * 2005-03-03 2006-09-14 F. Hoffman-La Roche Ag 1- sulfonyl-pi perdine- 3 -carboxyl i c acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056745A2 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as 11-beta hydroxysteroid dehydrogenase inhibitors
WO2006094633A1 (en) * 2005-03-03 2006-09-14 F. Hoffman-La Roche Ag 1- sulfonyl-pi perdine- 3 -carboxyl i c acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus

Also Published As

Publication number Publication date
WO2008087654A2 (en) 2008-07-24

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