EA201171413A1 - Способ получения олмесартана медоксомила - Google Patents

Способ получения олмесартана медоксомила

Info

Publication number
EA201171413A1
EA201171413A1 EA201171413A EA201171413A EA201171413A1 EA 201171413 A1 EA201171413 A1 EA 201171413A1 EA 201171413 A EA201171413 A EA 201171413A EA 201171413 A EA201171413 A EA 201171413A EA 201171413 A1 EA201171413 A1 EA 201171413A1
Authority
EA
Eurasian Patent Office
Prior art keywords
olmesartan medoxomil
producing olmesartan
producing
olm
removable
Prior art date
Application number
EA201171413A
Other languages
English (en)
Inventor
Ашвини Кумар Капур
Хитен Шарадчандра Мета
Асок Нат
Мохан Прасад
Original Assignee
Ранбакси Лабораториз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ранбакси Лабораториз Лимитед filed Critical Ранбакси Лабораториз Лимитед
Publication of EA201171413A1 publication Critical patent/EA201171413A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Согласно настоящему изобретению предложен улучшенный способ получения олмесартана медоксомила, который не содержит ОЛМ-кислоты и имеет более низкое содержание удаляемой и уксуснокислой примеси.
EA201171413A 2009-05-20 2010-05-20 Способ получения олмесартана медоксомила EA201171413A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1037DE2009 2009-05-20
PCT/IB2010/052260 WO2010134052A1 (en) 2009-05-20 2010-05-20 Process for the preparation of olmesartan medoxomil

Publications (1)

Publication Number Publication Date
EA201171413A1 true EA201171413A1 (ru) 2012-09-28

Family

ID=42306735

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171413A EA201171413A1 (ru) 2009-05-20 2010-05-20 Способ получения олмесартана медоксомила

Country Status (12)

Country Link
US (1) US20120184750A1 (ru)
EP (1) EP2432777A1 (ru)
JP (1) JP2012527446A (ru)
KR (1) KR20120046115A (ru)
CN (1) CN102459243A (ru)
AP (1) AP2011005999A0 (ru)
AU (1) AU2010250827A1 (ru)
BR (1) BRPI1010969A2 (ru)
CA (1) CA2762846A1 (ru)
EA (1) EA201171413A1 (ru)
MX (1) MX2011012460A (ru)
WO (1) WO2010134052A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ305129B6 (cs) * 2010-11-24 2015-05-13 Zentiva, K.S. (5-Methyl-2-oxo-1,3-dioxol-4-ylmethyl)-4-(1-hydroxy-1-methyl-propyl)-2-propyl-1-[2´-(1H-tetrazol-5-yl)bifenyl-4-yl-methyl]imidazol-5-karboxylát jako nečistota olmesartan medoxomilu a způsob jeho přípravy
KR101418871B1 (ko) * 2012-08-28 2014-07-17 한국과학기술연구원 올메사탄 메독소밀의 정제방법
CN104447208B (zh) * 2014-11-28 2016-08-24 山东新华制药股份有限公司 从奥美沙坦酯生产废液中回收三苯基甲醇的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
CA2141175C (en) 1994-01-28 2006-12-12 Yasushi Shida A process for the production of tetrazolyl compounds
ATE482950T1 (de) 2003-08-27 2010-10-15 Zentiva Ks Verfahren zur entfernung der triphenylmethanschutzgruppe
ITMI20032338A1 (it) 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.
KR100953878B1 (ko) 2004-09-02 2010-04-22 테바 파마슈티컬 인더스트리즈 리미티드 올메살탄 메독소밀의 정제
CN1976926A (zh) * 2004-09-02 2007-06-06 特瓦制药工业有限公司 奥美沙坦酯的制备
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
WO2006050922A1 (en) 2004-11-11 2006-05-18 Lek Pharmaceuticals D.D. Process for the synthesis of tetrazoles
EP1716138A1 (en) 2004-12-30 2006-11-02 Teva Pharmaceutical Industries Ltd Process for preparing olmesartan medoxomil at ph higher than 2.5
CN101094850A (zh) * 2005-01-03 2007-12-26 特瓦制药工业有限公司 具有较低水平杂质的奥美沙坦酯
CZ299902B6 (cs) 2005-10-27 2008-12-29 Zentiva, A. S Zpusob odstranování trifenylmethanové chránicí skupiny u prekurzoru antihypertenzních léciv
US8048904B2 (en) * 2006-06-19 2011-11-01 Matrix Laboratories Ltd. Process for the preparation of olmesartan medoxomil
WO2008043996A2 (en) 2006-10-09 2008-04-17 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil

Also Published As

Publication number Publication date
US20120184750A1 (en) 2012-07-19
WO2010134052A1 (en) 2010-11-25
KR20120046115A (ko) 2012-05-09
EP2432777A1 (en) 2012-03-28
CN102459243A (zh) 2012-05-16
BRPI1010969A2 (pt) 2019-01-15
MX2011012460A (es) 2012-04-20
AP2011005999A0 (en) 2011-12-31
AU2010250827A1 (en) 2012-01-19
CA2762846A1 (en) 2010-11-25
JP2012527446A (ja) 2012-11-08

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