ATE482950T1 - Verfahren zur entfernung der triphenylmethanschutzgruppe - Google Patents
Verfahren zur entfernung der triphenylmethanschutzgruppeInfo
- Publication number
- ATE482950T1 ATE482950T1 AT04762303T AT04762303T ATE482950T1 AT E482950 T1 ATE482950 T1 AT E482950T1 AT 04762303 T AT04762303 T AT 04762303T AT 04762303 T AT04762303 T AT 04762303T AT E482950 T1 ATE482950 T1 AT E482950T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- protecting group
- removal
- triphenylmethane protecting
- triphenylmethane
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical group C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 title abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002083 C09CA01 - Losartan Substances 0.000 abstract 1
- 239000004072 C09CA03 - Valsartan Chemical class 0.000 abstract 1
- 239000002947 C09CA04 - Irbesartan Chemical class 0.000 abstract 1
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical class C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 abstract 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229960004349 candesartan cilexetil Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 229960002198 irbesartan Drugs 0.000 abstract 1
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical class O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 abstract 1
- 229960004773 losartan Drugs 0.000 abstract 1
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical class CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 159000000001 potassium salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000003797 solvolysis reaction Methods 0.000 abstract 1
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical class C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 abstract 1
- 229960004699 valsartan Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
- Dicing (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Manufacture Of Electron Tubes, Discharge Lamp Vessels, Lead-In Wires, And The Like (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20032319A CZ297016B6 (cs) | 2003-08-27 | 2003-08-27 | Zpusob odstranování trifenylmethanové chránicí skupiny z 1-trityl-5-(4'-subst. aminomethyl-1,1' -bifenyl-2-yl)-1H-tetrazolu a zpusob výroby draselné soli losartanu, irbesartanu a valsartanu s jeho pouzitím |
| CZ20040733A CZ298329B6 (cs) | 2004-06-16 | 2004-06-16 | Zpusob výroby 1-(cyklohexyloxykarbonyloxy)ethyl-2-ethoxy-1-[[2´-(1H-tetrazol-5-yl)bifenyl-4-yl]methyl]benzimidazol-7-karboxylátu (candesartan cilexetilu) |
| PCT/CZ2004/000051 WO2005021535A2 (en) | 2003-08-27 | 2004-08-26 | A method of removing the triphenylmethane protecting group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482950T1 true ATE482950T1 (de) | 2010-10-15 |
Family
ID=34276338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04762303T ATE482950T1 (de) | 2003-08-27 | 2004-08-26 | Verfahren zur entfernung der triphenylmethanschutzgruppe |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060287537A1 (de) |
| EP (1) | EP1658281B1 (de) |
| AT (1) | ATE482950T1 (de) |
| CA (1) | CA2536781A1 (de) |
| DE (1) | DE602004029373D1 (de) |
| EA (1) | EA011507B1 (de) |
| ES (1) | ES2348300T3 (de) |
| HR (1) | HRP20060119A2 (de) |
| PL (2) | PL379886A1 (de) |
| PT (1) | PT1658281E (de) |
| RS (1) | RS20060125A (de) |
| SK (1) | SK50142006A3 (de) |
| WO (1) | WO2005021535A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7692023B2 (en) | 2004-02-11 | 2010-04-06 | Teva Pharmaceutical Industries Ltd. | Candesartan cilexetil polymorphs |
| WO2006050922A1 (en) * | 2004-11-11 | 2006-05-18 | Lek Pharmaceuticals D.D. | Process for the synthesis of tetrazoles |
| EP1661891A1 (de) * | 2004-11-30 | 2006-05-31 | KRKA, D.D., Novo Mesto | Verfahren zur Herstellung von Valsartan |
| SI22127A (sl) | 2005-10-07 | 2007-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo kandesartan cileksetila |
| CZ299902B6 (cs) * | 2005-10-27 | 2008-12-29 | Zentiva, A. S | Zpusob odstranování trifenylmethanové chránicí skupiny u prekurzoru antihypertenzních léciv |
| WO2008018843A1 (en) * | 2006-08-08 | 2008-02-14 | Ulkar Kimya Sanayi Ve Ticaret As | Process for producing useful salts form of biphenyl-tetrazole compounds |
| WO2009125416A2 (en) | 2008-04-07 | 2009-10-15 | Hetero Research Foundation | Process for preparation of valsartan intermediate |
| WO2010046804A2 (en) * | 2008-10-21 | 2010-04-29 | Alembic Limited | A process for preparation of losartan potassium form i |
| AP2011005999A0 (en) | 2009-05-20 | 2011-12-31 | Ranbaxy Lab Ltd | Process for the preparation of olmesartan medoxomil. |
| WO2011080684A1 (en) | 2009-12-31 | 2011-07-07 | Ranbaxy Laboratories Limited | Process for the preparation of candesartan cilexetil |
| WO2011092666A1 (en) | 2010-01-29 | 2011-08-04 | Ranbaxy Laboratories Limited | An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof |
| CN103012382B (zh) * | 2012-12-05 | 2016-10-05 | 迪沙药业集团有限公司 | 一种奥美沙坦酯的制备方法 |
| ES2895174T3 (es) * | 2014-09-29 | 2022-02-17 | Scripps Research Inst | Moduladores del receptor de esfingosina-1-fosfato para el tratamiento de trastornos cardiopulmonares |
| US11327065B1 (en) * | 2021-08-27 | 2022-05-10 | Jubilant Generics Limited | Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof |
| CN116606282A (zh) * | 2023-05-17 | 2023-08-18 | 杭州新曦科技有限公司 | 用于制备氯沙坦钾及其相关中间体的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE134624T1 (de) * | 1990-02-19 | 1996-03-15 | Ciba Geigy Ag | Acylverbindungen |
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| AT395853B (de) * | 1991-01-31 | 1993-03-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| US5281604A (en) * | 1993-04-23 | 1994-01-25 | American Cyanamid Company | Angiotensin II receptor blocking 2,3,6-substituted quinazolinones |
| SK722003A3 (en) * | 2001-05-18 | 2003-12-02 | Aurobindo Pharma Ltd | Process for the crystallization of losartan potassium |
-
2004
- 2004-08-26 AT AT04762303T patent/ATE482950T1/de not_active IP Right Cessation
- 2004-08-26 ES ES04762303T patent/ES2348300T3/es not_active Expired - Lifetime
- 2004-08-26 CA CA002536781A patent/CA2536781A1/en not_active Abandoned
- 2004-08-26 SK SK5014-2006A patent/SK50142006A3/sk unknown
- 2004-08-26 EP EP04762303A patent/EP1658281B1/de not_active Expired - Lifetime
- 2004-08-26 RS YUP-2006/0125A patent/RS20060125A/sr unknown
- 2004-08-26 PL PL379886A patent/PL379886A1/pl not_active Application Discontinuation
- 2004-08-26 PT PT04762303T patent/PT1658281E/pt unknown
- 2004-08-26 EA EA200600079A patent/EA011507B1/ru not_active IP Right Cessation
- 2004-08-26 DE DE602004029373T patent/DE602004029373D1/de not_active Expired - Lifetime
- 2004-08-26 US US10/569,428 patent/US20060287537A1/en not_active Abandoned
- 2004-08-26 WO PCT/CZ2004/000051 patent/WO2005021535A2/en not_active Ceased
- 2004-08-26 PL PL04762303T patent/PL1658281T3/pl unknown
- 2004-08-26 HR HR20060119A patent/HRP20060119A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL379886A1 (pl) | 2006-11-27 |
| WO2005021535A2 (en) | 2005-03-10 |
| EP1658281A2 (de) | 2006-05-24 |
| SK50142006A3 (sk) | 2006-05-04 |
| WO2005021535A3 (en) | 2005-06-09 |
| RS20060125A (sr) | 2008-06-05 |
| EA200600079A1 (ru) | 2006-08-25 |
| ES2348300T3 (es) | 2010-12-02 |
| DE602004029373D1 (de) | 2010-11-11 |
| EP1658281B1 (de) | 2010-09-29 |
| EA011507B1 (ru) | 2009-04-28 |
| CA2536781A1 (en) | 2005-03-10 |
| PT1658281E (pt) | 2010-10-12 |
| US20060287537A1 (en) | 2006-12-21 |
| PL1658281T3 (pl) | 2010-12-31 |
| HRP20060119A2 (en) | 2006-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |