RS20060125A - A method of removing the triphenylmethane protecting group - Google Patents
A method of removing the triphenylmethane protecting groupInfo
- Publication number
- RS20060125A RS20060125A YUP-2006/0125A YUP20060125A RS20060125A RS 20060125 A RS20060125 A RS 20060125A YU P20060125 A YUP20060125 A YU P20060125A RS 20060125 A RS20060125 A RS 20060125A
- Authority
- RS
- Serbia
- Prior art keywords
- protecting group
- triphenylmethane protecting
- triphenylmethane
- ring
- tetrazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Ova prijave se odnosi na postupak za uklanjanje grupe za zaštitu trifenilmetana iz iz l-trifenilmetil-5-( 4' -supst. aminometil-l, l' -bifenil-2-il)-1H-tetrazola opšte formule I u kojoj R predstavlja grupe sa formulama i gde R1, R2, i R3 mogu da budu H, halogen, nerazgranati ili razgranati C1-C5alkil, C1-C5hidroksialkil, C1-C5alkoksi, C1-C5 alkoksimetil, ili benzil, ili gde R2 i R3 mogu zajedno da grade C5-C7 zasićeni ili nezasićeni prsten, po slobodnom izboru nesupstituisan ili supstituisan aromatični prsten, i gde se postupak vrši solvolizom u prostom anhidrovanom alkoholu sa Cl do C5 atoma ugljenika u neutralnoj ili blago baznoj sredini. Postupak je pogodan za dobijanje lekova, kao što su kalijumove soli lozartana, irbezartana ili valzartana ili kandezartan cileksetila.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20032319A CZ297016B6 (cs) | 2003-08-27 | 2003-08-27 | Zpusob odstranování trifenylmethanové chránicí skupiny z 1-trityl-5-(4'-subst. aminomethyl-1,1' -bifenyl-2-yl)-1H-tetrazolu a zpusob výroby draselné soli losartanu, irbesartanu a valsartanu s jeho pouzitím |
CZ20040733A CZ298329B6 (cs) | 2004-06-16 | 2004-06-16 | Zpusob výroby 1-(cyklohexyloxykarbonyloxy)ethyl-2-ethoxy-1-[[2´-(1H-tetrazol-5-yl)bifenyl-4-yl]methyl]benzimidazol-7-karboxylátu (candesartan cilexetilu) |
PCT/CZ2004/000051 WO2005021535A2 (en) | 2003-08-27 | 2004-08-26 | A method of removing the triphenylmethane protecting group |
Publications (1)
Publication Number | Publication Date |
---|---|
RS20060125A true RS20060125A (en) | 2008-06-05 |
Family
ID=34276338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2006/0125A RS20060125A (en) | 2003-08-27 | 2004-08-26 | A method of removing the triphenylmethane protecting group |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060287537A1 (sr) |
EP (1) | EP1658281B1 (sr) |
AT (1) | ATE482950T1 (sr) |
CA (1) | CA2536781A1 (sr) |
DE (1) | DE602004029373D1 (sr) |
EA (1) | EA011507B1 (sr) |
ES (1) | ES2348300T3 (sr) |
HR (1) | HRP20060119A2 (sr) |
PL (2) | PL1658281T3 (sr) |
PT (1) | PT1658281E (sr) |
RS (1) | RS20060125A (sr) |
SK (1) | SK50142006A3 (sr) |
WO (1) | WO2005021535A2 (sr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2555294A1 (en) | 2004-02-11 | 2005-08-25 | Marina Yu Etinger | Candesartan cilexetil polymorphs |
WO2006050922A1 (en) * | 2004-11-11 | 2006-05-18 | Lek Pharmaceuticals D.D. | Process for the synthesis of tetrazoles |
EP1661891A1 (en) * | 2004-11-30 | 2006-05-31 | KRKA, D.D., Novo Mesto | A process for the synthesis of valsartan |
SI22127A (sl) | 2005-10-07 | 2007-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo kandesartan cileksetila |
CZ299902B6 (cs) * | 2005-10-27 | 2008-12-29 | Zentiva, A. S | Zpusob odstranování trifenylmethanové chránicí skupiny u prekurzoru antihypertenzních léciv |
WO2008018843A1 (en) * | 2006-08-08 | 2008-02-14 | Ulkar Kimya Sanayi Ve Ticaret As | Process for producing useful salts form of biphenyl-tetrazole compounds |
EP2260018A2 (en) | 2008-04-07 | 2010-12-15 | Hetero Research Foundation | Process for preparation of valsartan intermediate |
WO2010046804A2 (en) * | 2008-10-21 | 2010-04-29 | Alembic Limited | A process for preparation of losartan potassium form i |
EP2432777A1 (en) | 2009-05-20 | 2012-03-28 | Ranbaxy Laboratories Limited | Process for the preparation of olmesartan medoxomil |
WO2011080684A1 (en) | 2009-12-31 | 2011-07-07 | Ranbaxy Laboratories Limited | Process for the preparation of candesartan cilexetil |
WO2011092666A1 (en) | 2010-01-29 | 2011-08-04 | Ranbaxy Laboratories Limited | An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof |
CN103012382B (zh) * | 2012-12-05 | 2016-10-05 | 迪沙药业集团有限公司 | 一种奥美沙坦酯的制备方法 |
CN107001806B (zh) * | 2014-09-29 | 2020-12-04 | 斯克利普斯研究院 | 用于治疗心肺疾病的鞘氨醇-1-磷酸盐受体调节剂 |
US11327065B1 (en) * | 2021-08-27 | 2022-05-10 | Jubilant Generics Limited | Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH30484A (en) * | 1990-02-19 | 1997-05-28 | Ciba Geigy | Acy compounds pharmaceutical composition containing said compound and method of use thereof |
US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
AT395853B (de) * | 1991-01-31 | 1993-03-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
US5281604A (en) * | 1993-04-23 | 1994-01-25 | American Cyanamid Company | Angiotensin II receptor blocking 2,3,6-substituted quinazolinones |
SK722003A3 (en) * | 2001-05-18 | 2003-12-02 | Aurobindo Pharma Ltd | Process for the crystallization of losartan potassium |
-
2004
- 2004-08-26 WO PCT/CZ2004/000051 patent/WO2005021535A2/en active Application Filing
- 2004-08-26 SK SK5014-2006A patent/SK50142006A3/sk unknown
- 2004-08-26 PL PL04762303T patent/PL1658281T3/pl unknown
- 2004-08-26 DE DE602004029373T patent/DE602004029373D1/de active Active
- 2004-08-26 ES ES04762303T patent/ES2348300T3/es active Active
- 2004-08-26 PT PT04762303T patent/PT1658281E/pt unknown
- 2004-08-26 PL PL379886A patent/PL379886A1/pl not_active Application Discontinuation
- 2004-08-26 AT AT04762303T patent/ATE482950T1/de not_active IP Right Cessation
- 2004-08-26 EA EA200600079A patent/EA011507B1/ru not_active IP Right Cessation
- 2004-08-26 US US10/569,428 patent/US20060287537A1/en not_active Abandoned
- 2004-08-26 CA CA002536781A patent/CA2536781A1/en not_active Abandoned
- 2004-08-26 RS YUP-2006/0125A patent/RS20060125A/sr unknown
- 2004-08-26 EP EP04762303A patent/EP1658281B1/en active Active
-
2006
- 2006-03-24 HR HR20060119A patent/HRP20060119A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA011507B1 (ru) | 2009-04-28 |
PL379886A1 (pl) | 2006-11-27 |
HRP20060119A2 (en) | 2006-05-31 |
WO2005021535A3 (en) | 2005-06-09 |
WO2005021535A2 (en) | 2005-03-10 |
US20060287537A1 (en) | 2006-12-21 |
DE602004029373D1 (de) | 2010-11-11 |
ES2348300T3 (es) | 2010-12-02 |
ATE482950T1 (de) | 2010-10-15 |
EP1658281B1 (en) | 2010-09-29 |
PL1658281T3 (pl) | 2010-12-31 |
EA200600079A1 (ru) | 2006-08-25 |
EP1658281A2 (en) | 2006-05-24 |
SK50142006A3 (sk) | 2006-05-04 |
PT1658281E (pt) | 2010-10-12 |
CA2536781A1 (en) | 2005-03-10 |
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