WO2010018441A3 - Process for the preparation of substantially pure telmisartan - Google Patents

Process for the preparation of substantially pure telmisartan Download PDF

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Publication number
WO2010018441A3
WO2010018441A3 PCT/IB2009/006505 IB2009006505W WO2010018441A3 WO 2010018441 A3 WO2010018441 A3 WO 2010018441A3 IB 2009006505 W IB2009006505 W IB 2009006505W WO 2010018441 A3 WO2010018441 A3 WO 2010018441A3
Authority
WO
WIPO (PCT)
Prior art keywords
pure telmisartan
telmisartan
pure
polymorphic
improved
Prior art date
Application number
PCT/IB2009/006505
Other languages
French (fr)
Other versions
WO2010018441A2 (en
Inventor
Bakulesh Mafatlal Khamar
Ishrat Husain Siddiqui
Ravi Ponnaiah
Indravadan Ambalal Modi
Original Assignee
Cadila Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IN1695MU2008 priority Critical
Priority to IN1695/MUM/2008 priority
Application filed by Cadila Pharmaceuticals Ltd. filed Critical Cadila Pharmaceuticals Ltd.
Publication of WO2010018441A2 publication Critical patent/WO2010018441A2/en
Publication of WO2010018441A3 publication Critical patent/WO2010018441A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Abstract

The present invention relates to an improved process for the preparation of substantially pure Telmisartan in polymorphic form A.
PCT/IB2009/006505 2008-08-11 2009-08-10 An improved process for the preparation of substantially pure telmisartan WO2010018441A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN1695MU2008 2008-08-11
IN1695/MUM/2008 2008-08-11

Publications (2)

Publication Number Publication Date
WO2010018441A2 WO2010018441A2 (en) 2010-02-18
WO2010018441A3 true WO2010018441A3 (en) 2010-04-08

Family

ID=41510778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/006505 WO2010018441A2 (en) 2008-08-11 2009-08-10 An improved process for the preparation of substantially pure telmisartan

Country Status (1)

Country Link
WO (1) WO2010018441A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012055941A1 (en) 2010-10-27 2012-05-03 Krka,Tovarna Zdravil, D. D., Novo Mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
CN101983962A (en) * 2010-12-07 2011-03-09 福州海王福药制药有限公司 Preparation technology of telmisartan active pharmaceutical ingredient
CN103787982A (en) * 2012-10-31 2014-05-14 上海特化医药科技有限公司 Telmisartan preparation method and intermediate of telmisartan

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1344712A (en) * 2001-07-30 2002-04-17 中国科学院上海药物研究所 Synthesis path of Timisatem
WO2005108375A1 (en) * 2004-05-11 2005-11-17 Cipla Limited Process for the preparation of telmisartan
WO2006044754A2 (en) * 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
US20060211866A1 (en) * 2005-03-21 2006-09-21 Glenmark Pharmaceuticals Limited Process for the preparation of angiotensin receptor blockers and intermediates thereof
EP1719766A2 (en) * 2005-05-03 2006-11-08 Dipharma S.p.A. A process for the preparation of telmisartan
US20060276525A1 (en) * 2005-05-18 2006-12-07 Itai Adin Processes of preparing highly pure telmisartan form A, suitable for pharmaceutical compositions
WO2009006860A2 (en) * 2007-07-09 2009-01-15 Zentiva A.S. A method of manufacturing 4'-[[4-methyl-6-(1-methyl-1h-benzimidazol-2-yl)-2-propyl-1h-benzimidazol-1yl]methyl]biphenyl-2-carboxylic acid (telmisartan)

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1344712A (en) * 2001-07-30 2002-04-17 中国科学院上海药物研究所 Synthesis path of Timisatem
WO2005108375A1 (en) * 2004-05-11 2005-11-17 Cipla Limited Process for the preparation of telmisartan
WO2006044754A2 (en) * 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
US20060211866A1 (en) * 2005-03-21 2006-09-21 Glenmark Pharmaceuticals Limited Process for the preparation of angiotensin receptor blockers and intermediates thereof
EP1719766A2 (en) * 2005-05-03 2006-11-08 Dipharma S.p.A. A process for the preparation of telmisartan
US20060276525A1 (en) * 2005-05-18 2006-12-07 Itai Adin Processes of preparing highly pure telmisartan form A, suitable for pharmaceutical compositions
WO2009006860A2 (en) * 2007-07-09 2009-01-15 Zentiva A.S. A method of manufacturing 4'-[[4-methyl-6-(1-methyl-1h-benzimidazol-2-yl)-2-propyl-1h-benzimidazol-1yl]methyl]biphenyl-2-carboxylic acid (telmisartan)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200255, Derwent World Patents Index; AN 2002-509498, XP002568692 *
REDDY KIKKURU SRIRAMI ET AL: "An Efficient and Impurity-Free Process for Telmisartan: An Antihypertensive Drug", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 11, 1 January 2007 (2007-01-01), pages 81 - 85, XP002548424, ISSN: 1083-6160, [retrieved on 20061012] *

Also Published As

Publication number Publication date
WO2010018441A2 (en) 2010-02-18

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