MX2010008553A - Procedimiento para la sintesis regioselectiva de derivados de acido 1-alquil-3-haloalquil-pirazol-4-carboxilico. - Google Patents

Procedimiento para la sintesis regioselectiva de derivados de acido 1-alquil-3-haloalquil-pirazol-4-carboxilico.

Info

Publication number
MX2010008553A
MX2010008553A MX2010008553A MX2010008553A MX2010008553A MX 2010008553 A MX2010008553 A MX 2010008553A MX 2010008553 A MX2010008553 A MX 2010008553A MX 2010008553 A MX2010008553 A MX 2010008553A MX 2010008553 A MX2010008553 A MX 2010008553A
Authority
MX
Mexico
Prior art keywords
acid derivatives
haloalkyl
alkyl
carboxylic acid
pyroazole
Prior art date
Application number
MX2010008553A
Other languages
English (en)
Inventor
Sergii Pazenok
Norbert Lui
Jans-Dietmar Heinrich
Thomas Wollner
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39590527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010008553(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of MX2010008553A publication Critical patent/MX2010008553A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/78—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/80—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención se refiere a un procedimiento para la síntesis regioselectiva de derivados de ácido 1-alquil-3-haloalquil-pirazol-4-carboxílico mediante ciclación de derivados de ácido acrílico 2,3-disustituidos, así como a las hidrazonas formadas en el procedimiento como productos intermedios.
MX2010008553A 2008-02-25 2009-02-12 Procedimiento para la sintesis regioselectiva de derivados de acido 1-alquil-3-haloalquil-pirazol-4-carboxilico. MX2010008553A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08151891A EP2133341A1 (de) 2008-02-25 2008-02-25 Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
PCT/EP2009/000958 WO2009106230A2 (de) 2008-02-25 2009-02-12 Verfahren zur regioselektiven synthese von 1-alkyl-3-haloalkyl-pyrazol-4-carbonsäur e-derivaten

Publications (1)

Publication Number Publication Date
MX2010008553A true MX2010008553A (es) 2010-09-24

Family

ID=39590527

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015009067A MX344084B (es) 2008-02-25 2009-02-12 Procedimiento para la síntesis regioselectiva de derivados de ácido 1-alquil-3-haloalquil-pirazol-4-carboxílico.
MX2010008553A MX2010008553A (es) 2008-02-25 2009-02-12 Procedimiento para la sintesis regioselectiva de derivados de acido 1-alquil-3-haloalquil-pirazol-4-carboxilico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015009067A MX344084B (es) 2008-02-25 2009-02-12 Procedimiento para la síntesis regioselectiva de derivados de ácido 1-alquil-3-haloalquil-pirazol-4-carboxílico.

Country Status (15)

Country Link
US (2) US8629288B2 (es)
EP (2) EP2133341A1 (es)
JP (2) JP5756293B2 (es)
KR (1) KR101656690B1 (es)
CN (2) CN102026981B (es)
BR (2) BR122016027233B1 (es)
CA (1) CA2716381C (es)
DK (1) DK2247577T4 (es)
ES (1) ES2561038T5 (es)
IL (1) IL207151A0 (es)
MX (2) MX344084B (es)
MY (2) MY170036A (es)
RU (2) RU2498977C9 (es)
TW (1) TWI458712B (es)
WO (1) WO2009106230A2 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801906A (zh) 2007-08-16 2010-08-11 索尔维公司 制备4-氟取代的3-氧代-烷酸酯的方法
EP2133341A1 (de) * 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
EP2100883A1 (de) * 2008-03-10 2009-09-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten
JP5587293B2 (ja) * 2008-05-05 2014-09-10 ビーエーエスエフ ソシエタス・ヨーロピア １，３，４−置換ピラゾール化合物の調製方法
JP2014523425A (ja) 2011-06-21 2014-09-11 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ピラゾリルカルボキシアニリドの製造
US9012657B2 (en) 2011-06-22 2015-04-21 Central Glass Company, Limited Method for producing pyrazole compound
EP2623496A1 (de) 2012-02-01 2013-08-07 Bayer CropScience AG Verfahren zur Herstellung von 3,5-bis (fluoralkyl)-pyrazol-4-carbonsäure-Derivaten und 3,5-bis(fluoralkyl)-pyrazolen
EP2644593A1 (en) * 2012-03-30 2013-10-02 Solvay Sa Dialkoxymethyl oxobutyric acid esters, their manufacture and use
EP2644598A1 (en) 2012-03-30 2013-10-02 Solvay Sa Method for the manufacture of heterocycles
CA2871694A1 (en) 2012-05-16 2013-11-21 Solvay Sa Manufacture of 1-substituted methylidene compounds
EP2671874B1 (en) 2012-06-06 2016-01-13 Solvay Sa Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids
EP2671873A1 (en) 2012-06-06 2013-12-11 Solvay Sa Method for the cyclization of hydrazinoacrylic acid derivatives
US8871947B2 (en) 2013-02-04 2014-10-28 KingChem LLC Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester
MX361995B (es) * 2013-05-22 2018-12-19 Bayer Cropscience Ag Proceso para preparar derivados de 3, 5-bis (fluoroalquil) pirazol a partir de a, a-dihaloaminas.
CN105473555B (zh) * 2013-05-22 2018-04-24 拜耳作物科学股份公司 制备3,5-双(氟烷基)吡唑衍生物的方法
CN103360313A (zh) * 2013-07-12 2013-10-23 雅本化学股份有限公司 3-氟代烷基-1-取代吡唑-4-羧酸及其制备方法
TWI647215B (zh) * 2013-11-11 2019-01-11 德商拜耳作物科學股份有限公司 自α,α－二鹵胺製備３,５－雙鹵烷基吡唑衍生物之方法
WO2015085464A1 (en) 2013-12-09 2015-06-18 King Chem, Llc Process for preparing alkyl 3-difluoromethyl-1-methyl-1h-pyrazole-4-carboxylate and its analogs
JP6431088B2 (ja) * 2014-03-24 2018-11-28 バイエル・クロップサイエンス・アクチェンゲゼルシャフト α，α−ジハロアミン類およびケチミン類からの３，５−ビス（ハロアルキル）ピラゾール誘導体の製造方法
EP3015458A1 (en) 2014-11-03 2016-05-04 Bayer CropScience AG Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines
US9856222B2 (en) 2014-06-11 2018-01-02 Bayer Cropscience Aktiengesellschaft Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives via acylation of hydrazones
DK3154947T3 (en) 2014-06-11 2018-06-18 Bayer Cropscience Ag PROCEDURE FOR PREPARING 3,5-BIS (HALOGENAL COOL) PYRAZOLES BY ACYLATION OF KETIMINES
CN105541716B (zh) 2015-03-26 2024-02-23 Ａｇｃ株式会社 吡唑衍生物的制造方法
US10273215B2 (en) 2015-06-26 2019-04-30 Bayer Cropscience Aktiengesellschaft Process for preparing substituted pyrazoles containing haloalkoxy- and haloalkylthio groups from alpha,alpha -dihaloalkylamines and ketimines
CN106467492B (zh) * 2015-08-14 2019-12-17 联化科技(盐城)有限公司 多氟甲基吡唑类化合物的制备方法、中间体及制备方法
WO2017140593A1 (en) * 2016-02-18 2017-08-24 Solvay Sa Process for the manufacture of carboxamides
EP3494107A1 (en) 2016-08-02 2019-06-12 Solvay Sa Manufacture of hydrazinyl compounds useful in the manufacture of pyrazole carboxylic acid and derivatives, hydrazinyl compounds and their use
MX2019003255A (es) 2016-09-21 2019-07-18 Bayer Cropscience Ag Proceso para la preparacion de 3-fluoroalquil-5-pirazolcarboxilato s y acidos 3-fluoroalquil-5-pirazolcarboxilicos.
CN111566093A (zh) * 2017-12-22 2020-08-21 索尔维公司 吡唑甲酸衍生物及其前体的制造方法
US20210179563A1 (en) * 2017-12-22 2021-06-17 Solvay Sa Process for the manufacture of iminium compounds and their application in the manufacture of pyrazole derivatives
WO2019243178A1 (en) 2018-06-18 2019-12-26 Bayer Aktiengesellschaft Disubstituted 3-pyrazole carboxylates and a process for their preparation via acylation of enolates
WO2020093715A1 (en) 2018-11-07 2020-05-14 Fujian Yongjing Technology Co., Ltd New process for manufacture of pyrazoles or pyrimidones
CN112480007B (zh) * 2020-12-08 2022-11-18 宿迁市科莱博生物化学有限公司 一种1，3-二甲基-1h-吡唑-4-羧酸的合成方法
CN114195678A (zh) * 2021-12-24 2022-03-18 江苏七洲绿色科技研究院有限公司 一种中间体、其制备方法及用其制备3-二氟甲基-1-甲基吡唑-4-甲酸乙酯的方法
CN114195715B (zh) * 2021-12-31 2024-05-10 福建永晶科技股份有限公司 1-甲基-3-二氟甲基-4-吡唑酸和1-甲基-3-三氟甲基-4-吡唑酸的制备方法
CN117447401B (zh) * 2023-12-26 2024-04-19 山东国邦药业有限公司 一种二氟吡唑酸的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000035081A (ko) 1998-11-10 2000-06-26 마크 에스. 아들러 2-(트리할로아세틸)-3-(치환된 아미노)-2-프로페노에이트 제조방법
DE10215292A1 (de) 2002-02-19 2003-08-28 Bayer Cropscience Ag Disubstitutierte Pyrazolylcarbocanilide
DE10349500A1 (de) * 2003-10-23 2005-06-02 Bayer Cropscience Ag Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern
UA93860C2 (ru) * 2004-10-21 2011-03-25 Сингента Партисипейшнс Аг Способ получения пиразолов, способ региоселективного алкилирования и применение фосфата или фосфоната b способе
WO2006090778A1 (ja) 2005-02-25 2006-08-31 Sagami Chemical Research Center １－置換－３－フルオロアルキルピラゾール－４－カルボン酸エステルの製造方法
DE102006039909A1 (de) 2006-08-25 2008-03-13 Bayer Cropscience Ag Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten
DE102007005296A1 (de) 2007-02-02 2008-08-07 Bayer Cropscience Ag Verfahren zum Herstellen von Dihaloacetessigsäurealkylestern
EP2008996A1 (en) * 2007-06-27 2008-12-31 Syngeta Participations AG Process for the production of pyrazoles
EP2133341A1 (de) * 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
EP2100883A1 (de) * 2008-03-10 2009-09-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten
JP5587293B2 (ja) * 2008-05-05 2014-09-10 ビーエーエスエフ ソシエタス・ヨーロピア １，３，４−置換ピラゾール化合物の調製方法

Also Published As

Publication number Publication date
CA2716381A1 (en) 2009-09-03
US8592605B2 (en) 2013-11-26
US20130197239A1 (en) 2013-08-01
RU2661192C2 (ru) 2018-07-13
DK2247577T4 (da) 2022-07-18
MY156546A (en) 2016-02-26
RU2498977C9 (ru) 2014-09-20
JP5756293B2 (ja) 2015-07-29
DK2247577T3 (en) 2016-02-15
BR122016027233B1 (pt) 2018-06-05
KR101656690B1 (ko) 2016-09-12
ES2561038T5 (es) 2022-09-14
TWI458712B (zh) 2014-11-01
TW201002672A (en) 2010-01-16
MX344084B (es) 2016-12-05
CN102026981A (zh) 2011-04-20
WO2009106230A2 (de) 2009-09-03
CA2716381C (en) 2016-05-03
IL207151A0 (en) 2010-12-30
JP2015071615A (ja) 2015-04-16
CN102026981B (zh) 2014-10-29
EP2247577B1 (de) 2015-12-23
RU2498977C2 (ru) 2013-11-20
EP2247577B2 (de) 2022-04-27
EP2247577A2 (de) 2010-11-10
EP2133341A1 (de) 2009-12-16
ES2561038T3 (es) 2016-02-24
US8629288B2 (en) 2014-01-14
MY170036A (en) 2019-06-26
CN104277001A (zh) 2015-01-14
RU2013134651A (ru) 2015-01-27
US20110009642A1 (en) 2011-01-13
WO2009106230A3 (de) 2011-03-10
RU2010139278A (ru) 2012-04-10
JP2011518767A (ja) 2011-06-30
BRPI0908891A2 (pt) 2015-08-04
KR20100136456A (ko) 2010-12-28

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