MX344084B - Procedimiento para la síntesis regioselectiva de derivados de ácido 1-alquil-3-haloalquil-pirazol-4-carboxílico. - Google Patents

Procedimiento para la síntesis regioselectiva de derivados de ácido 1-alquil-3-haloalquil-pirazol-4-carboxílico.

Info

Publication number
MX344084B
MX344084B MX2015009067A MX2015009067A MX344084B MX 344084 B MX344084 B MX 344084B MX 2015009067 A MX2015009067 A MX 2015009067A MX 2015009067 A MX2015009067 A MX 2015009067A MX 344084 B MX344084 B MX 344084B
Authority
MX
Mexico
Prior art keywords
acid derivatives
alkyl
carboxylic acid
pyroazole
haloalkylâ
Prior art date
Application number
MX2015009067A
Other languages
English (en)
Inventor
Sergii Pazenok
Norbert Lui
Jens-Dietmar Heinrich
Thomas Wollner
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39590527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX344084(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of MX344084B publication Critical patent/MX344084B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/78—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/80—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención se refiere a un procedimiento para la síntesis regioselectiva de derivados de ácido 1-alquil-3-haloalquil-pirazol-4-carboxílico mediante ciclación de derivados de ácido acrílico 2,3-disustituidos, así como a las hidrazonas formadas en el procedimiento como productos intermedios.
MX2015009067A 2008-02-25 2009-02-12 Procedimiento para la síntesis regioselectiva de derivados de ácido 1-alquil-3-haloalquil-pirazol-4-carboxílico. MX344084B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08151891A EP2133341A1 (de) 2008-02-25 2008-02-25 Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
PCT/EP2009/000958 WO2009106230A2 (de) 2008-02-25 2009-02-12 Verfahren zur regioselektiven synthese von 1-alkyl-3-haloalkyl-pyrazol-4-carbonsäur e-derivaten

Publications (1)

Publication Number Publication Date
MX344084B true MX344084B (es) 2016-12-05

Family

ID=39590527

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010008553A MX2010008553A (es) 2008-02-25 2009-02-12 Procedimiento para la sintesis regioselectiva de derivados de acido 1-alquil-3-haloalquil-pirazol-4-carboxilico.
MX2015009067A MX344084B (es) 2008-02-25 2009-02-12 Procedimiento para la síntesis regioselectiva de derivados de ácido 1-alquil-3-haloalquil-pirazol-4-carboxílico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2010008553A MX2010008553A (es) 2008-02-25 2009-02-12 Procedimiento para la sintesis regioselectiva de derivados de acido 1-alquil-3-haloalquil-pirazol-4-carboxilico.

Country Status (15)

Country Link
US (2) US8629288B2 (es)
EP (2) EP2133341A1 (es)
JP (2) JP5756293B2 (es)
KR (1) KR101656690B1 (es)
CN (2) CN104277001A (es)
BR (2) BRPI0908891A2 (es)
CA (1) CA2716381C (es)
DK (1) DK2247577T4 (es)
ES (1) ES2561038T5 (es)
IL (1) IL207151A0 (es)
MX (2) MX2010008553A (es)
MY (2) MY170036A (es)
RU (2) RU2498977C9 (es)
TW (1) TWI458712B (es)
WO (1) WO2009106230A2 (es)

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WO2009021987A1 (en) 2007-08-16 2009-02-19 Solvay (Société Anonyme) Process for the preparation of esters of 4-fluorosubstituted 3-oxo-alcanoic acids
EP2133341A1 (de) * 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
EP2100883A1 (de) * 2008-03-10 2009-09-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten
AU2009243550B2 (en) * 2008-05-05 2014-06-26 Basf Se Method for preparing 1,3,4-substituted pyrazol compounds
BR112013032988A2 (pt) 2011-06-21 2016-08-16 Bayer Ip Gmbh método para a produção de pirazolilcarboxanilidas
US9012657B2 (en) 2011-06-22 2015-04-21 Central Glass Company, Limited Method for producing pyrazole compound
EP2623496A1 (de) 2012-02-01 2013-08-07 Bayer CropScience AG Verfahren zur Herstellung von 3,5-bis (fluoralkyl)-pyrazol-4-carbonsäure-Derivaten und 3,5-bis(fluoralkyl)-pyrazolen
EP2644598A1 (en) 2012-03-30 2013-10-02 Solvay Sa Method for the manufacture of heterocycles
EP2644593A1 (en) * 2012-03-30 2013-10-02 Solvay Sa Dialkoxymethyl oxobutyric acid esters, their manufacture and use
CN104284879A (zh) 2012-05-16 2015-01-14 索尔维公司 1-取代甲叉基化合物的制备
EP2671873A1 (en) 2012-06-06 2013-12-11 Solvay Sa Method for the cyclization of hydrazinoacrylic acid derivatives
EP2671874B1 (en) 2012-06-06 2016-01-13 Solvay Sa Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids
US8871947B2 (en) 2013-02-04 2014-10-28 KingChem LLC Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester
BR112015028751B1 (pt) 2013-05-22 2021-01-12 Bayer Cropscience Aktiengesellschaft Processo para a preparação de derivados de 3,5-bis (fluoralquil)pirazol a partir de alfa, alfa-dihaloaminas e uso destes para preparação de ingredientes fungicidas ativos
KR102233203B1 (ko) 2013-05-22 2021-03-26 바이엘 크롭사이언스 악티엔게젤샤프트 3,5-비스(플루오로알킬)피라졸 유도체의 제조방법
CN103360313A (zh) * 2013-07-12 2013-10-23 雅本化学股份有限公司 3-氟代烷基-1-取代吡唑-4-羧酸及其制备方法
TWI647215B (zh) 2013-11-11 2019-01-11 德商拜耳作物科學股份有限公司 自α,α－二鹵胺製備３,５－雙鹵烷基吡唑衍生物之方法
WO2015085464A1 (en) 2013-12-09 2015-06-18 King Chem, Llc Process for preparing alkyl 3-difluoromethyl-1-methyl-1h-pyrazole-4-carboxylate and its analogs
EP3015458A1 (en) 2014-11-03 2016-05-04 Bayer CropScience AG Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines
ES2663614T3 (es) * 2014-03-24 2018-04-16 Bayer Cropscience Aktiengesellschaft Procedimiento de preparación de derivados de 3,5-bis(haloalquil)pirazol a partir de alfa, alfa-dihaloaminas y cetiminas
WO2015189141A1 (en) 2014-06-11 2015-12-17 Bayer Cropscience Ag Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives via acylation of hydrazones
DK3154947T3 (en) 2014-06-11 2018-06-18 Bayer Cropscience Ag PROCEDURE FOR PREPARING 3,5-BIS (HALOGENAL COOL) PYRAZOLES BY ACYLATION OF KETIMINES
CN105541716B (zh) 2015-03-26 2024-02-23 Ａｇｃ株式会社 吡唑衍生物的制造方法
EP3313820A1 (en) 2015-06-26 2018-05-02 Bayer CropScience Aktiengesellschaft Process for preparing substituted pyrazoles containing haloalkoxy- and haloalkylthio groups from , -dihaloalkylamines and ketimines
CN106467492B (zh) * 2015-08-14 2019-12-17 联化科技(盐城)有限公司 多氟甲基吡唑类化合物的制备方法、中间体及制备方法
EP3416949A1 (en) * 2016-02-18 2018-12-26 Solvay Sa Process for the manufacture of carboxamides
WO2018024644A1 (en) 2016-08-02 2018-02-08 Solvay Sa Manufacture of hydrazinyl compounds useful in the manufacture of pyrazole carboxylic acid and derivatives, hydrazinyl compounds and their use
ES2849960T3 (es) 2016-09-21 2021-08-24 Bayer Cropscience Ag Procedimiento para la preparación de 3-fluoroalquil-5-pirazolcarboxilatos y ácidos 3-fluoroalquil-5-pirazolcarboxílicos
CN111587241A (zh) * 2017-12-22 2020-08-25 索尔维公司 亚胺鎓化合物的制造方法及其在制造吡唑衍生物中的应用
WO2019122164A1 (en) 2017-12-22 2019-06-27 Solvay Sa Process for the manufacture of pyrazole carboxylic derivatives and precursors thereof
MX2020013769A (es) 2018-06-18 2021-03-02 Bayer Ag Carboxilatos de 3-pirazol disustituidos y un proceso para su preparacion mediante la acilacion de enolatos.
WO2020093715A1 (en) 2018-11-07 2020-05-14 Fujian Yongjing Technology Co., Ltd New process for manufacture of pyrazoles or pyrimidones
CN112480007B (zh) * 2020-12-08 2022-11-18 宿迁市科莱博生物化学有限公司 一种1，3-二甲基-1h-吡唑-4-羧酸的合成方法
CN114195678A (zh) * 2021-12-24 2022-03-18 江苏七洲绿色科技研究院有限公司 一种中间体、其制备方法及用其制备3-二氟甲基-1-甲基吡唑-4-甲酸乙酯的方法
CN114195715B (zh) * 2021-12-31 2024-05-10 福建永晶科技股份有限公司 1-甲基-3-二氟甲基-4-吡唑酸和1-甲基-3-三氟甲基-4-吡唑酸的制备方法
CN117447401B (zh) * 2023-12-26 2024-04-19 山东国邦药业有限公司 一种二氟吡唑酸的合成方法

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KR20000035081A (ko) 1998-11-10 2000-06-26 마크 에스. 아들러 2-(트리할로아세틸)-3-(치환된 아미노)-2-프로페노에이트 제조방법
DE10215292A1 (de) 2002-02-19 2003-08-28 Bayer Cropscience Ag Disubstitutierte Pyrazolylcarbocanilide
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EP2133341A1 (de) * 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
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Also Published As

Publication number Publication date
RU2498977C9 (ru) 2014-09-20
JP5756293B2 (ja) 2015-07-29
US20130197239A1 (en) 2013-08-01
IL207151A0 (en) 2010-12-30
DK2247577T4 (da) 2022-07-18
MX2010008553A (es) 2010-09-24
CA2716381C (en) 2016-05-03
CN104277001A (zh) 2015-01-14
KR101656690B1 (ko) 2016-09-12
EP2247577B1 (de) 2015-12-23
RU2013134651A (ru) 2015-01-27
DK2247577T3 (en) 2016-02-15
US8592605B2 (en) 2013-11-26
ES2561038T5 (es) 2022-09-14
EP2247577B2 (de) 2022-04-27
ES2561038T3 (es) 2016-02-24
CN102026981A (zh) 2011-04-20
RU2498977C2 (ru) 2013-11-20
KR20100136456A (ko) 2010-12-28
JP2011518767A (ja) 2011-06-30
CN102026981B (zh) 2014-10-29
WO2009106230A2 (de) 2009-09-03
MY170036A (en) 2019-06-26
US20110009642A1 (en) 2011-01-13
WO2009106230A3 (de) 2011-03-10
TW201002672A (en) 2010-01-16
CA2716381A1 (en) 2009-09-03
BR122016027233B1 (pt) 2018-06-05
RU2661192C2 (ru) 2018-07-13
BRPI0908891A2 (pt) 2015-08-04
TWI458712B (zh) 2014-11-01
EP2133341A1 (de) 2009-12-16
JP2015071615A (ja) 2015-04-16
US8629288B2 (en) 2014-01-14
MY156546A (en) 2016-02-26
EP2247577A2 (de) 2010-11-10
RU2010139278A (ru) 2012-04-10

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