BR112016029394A2 - métodos, reagentes e células para biossintetizar composto - Google Patents

métodos, reagentes e células para biossintetizar composto

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Publication number
BR112016029394A2
BR112016029394A2 BR112016029394A BR112016029394A BR112016029394A2 BR 112016029394 A2 BR112016029394 A2 BR 112016029394A2 BR 112016029394 A BR112016029394 A BR 112016029394A BR 112016029394 A BR112016029394 A BR 112016029394A BR 112016029394 A2 BR112016029394 A2 BR 112016029394A2
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Brazil
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coa
biosynthesize
reagents
cells
compound
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BR112016029394A
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English (en)
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Leonora Botes Adriana
Van Eck Conradie Alex
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Invista Tech Sarl
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Publication of BR112016029394A2 publication Critical patent/BR112016029394A2/pt

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    • C12P7/62—Carboxylic acid esters
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    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
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    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/14—Hydrolases (3)
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    • C12Y102/99—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
    • C12Y102/99006—Carboxylate reductase (1.2.99.6)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01016—Acetyl-CoA C-acyltransferase (2.3.1.16)
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    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)
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    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01019—4-Aminobutyrate—2-oxoglutarate transaminase (2.6.1.19)
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    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01085—Pimelyl-[acyl-carrier protein] methyl ester esterase (3.1.1.85)
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    • C12Y301/02—Thioester hydrolases (3.1.2)

Abstract

este documento descreve vias bioquímicas para a produção de éster metílico de 2(e)-heptenodioil-coa a partir de precursores tais como 2-oxo-glutarato, acetil-coa ou succinil-coa utilizando uma ou mais de uma o-metiltransferase de ácido graxo, uma tioesterase, uma coa-transferase, uma coa ligase, bem como hospedeiros recombinantes que expressam uma ou mais destas enzimas. o éster metílico de 2(e)-heptenodioil-coa pode ser convertido enzimaticamente em pimeloil-coa utilizando uma trans-2-enoil-coa redutase, e uma metilesterase. pimeloil-coa pode ser convertida enzimaticamente em ácido pimélico, 7-aminoheptanoato, 7-hidroxi-heptanoato, heptametilenodiamina ou 1,7-heptanodiol.
BR112016029394A 2014-06-16 2015-06-16 métodos, reagentes e células para biossintetizar composto BR112016029394A2 (pt)

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US201462012735P 2014-06-16 2014-06-16
US201462012674P 2014-06-16 2014-06-16
PCT/US2015/035947 WO2015195611A2 (en) 2014-06-16 2015-06-16 Methods, reagents and cells for biosynthesizing compound

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BR112016029394A2 true BR112016029394A2 (pt) 2017-10-17

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US (2) US9896702B2 (pt)
EP (2) EP3155105A1 (pt)
CN (2) CN106795531A (pt)
BR (2) BR112016029394A2 (pt)
WO (2) WO2015195654A1 (pt)

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