AR083360A1 - Metodo para la preparacion de acido (3s,3s’) 4,4’-disulfanodiilbis-(3-aminobutano-1-sulfonico) y su trihidrato cristalino - Google Patents
Metodo para la preparacion de acido (3s,3s’) 4,4’-disulfanodiilbis-(3-aminobutano-1-sulfonico) y su trihidrato cristalinoInfo
- Publication number
- AR083360A1 AR083360A1 ARP110103726A ARP110103726A AR083360A1 AR 083360 A1 AR083360 A1 AR 083360A1 AR P110103726 A ARP110103726 A AR P110103726A AR P110103726 A ARP110103726 A AR P110103726A AR 083360 A1 AR083360 A1 AR 083360A1
- Authority
- AR
- Argentina
- Prior art keywords
- disulfanodiylbis
- give
- sulfonic acid
- acid
- neopentyloxysulfonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
- C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
- C07C321/14—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Método para la preparación de ácido (3S,3S’) 4,4’-disulfanodiilbis-(3-aminobutano-1-sulfónico) en cinco pasos a partir de (S) 2-(benciloxicarbonil amino)-4-(neopentiloxisulfonil)butanoato de etilo A.Reivindicación 1: Un proceso para preparar ácido (3S,3S’) 4,4’-disulfanodiilbis-(3-aminobutano-1-sulfónico) a partir de (S) 2-(benciloxicarbonilamino)-4-(neopentiloxisulfonil)butanoato de etilo A caracterizado porque comprende los pasos de: (a) reducir el éster etílico de A para dar el (S) 3-(benciloxicarbonilamino)-4-hidroxibutano-1-sulfonato de neopentilo B; (b) hacer reaccionar el alcohol B con anhídrido metansulfónico o cloruro de metanosulfonilo en presencia de una base para dar el (S) 3-(benciloxicarbonil amino)-4-(metilsulfoniloxi)butano-1-sulfonato de neopentilo C; (c) hacer reaccionar el alcohol mesilado C con tioacetato de potasio para dar el (S) tioacetato de 2-(benciloxicarbonilamino)-4-(neopentiloxisulfonil)butilo, (d) dimerizar D para dar el (3S,3S’) 4,4’-disulfanodiilbis (3-(benciloxicarbonil amino) butano-1-sulfonato) de neopentilo E; y (e) desproteger los grupos éster sulfónico y amina de E para dar el ácido (3S,3S’) 4,4’-disulfanodiilbis-(3-aminobutano-1-sulfónico). Reivindicación 18: El trihidrato cristalino del ácido (3S,3S’) 4,4’-disulfanodiilbis-(3-amino butano-1-sulfónico) caracterizado porque presenta esencialmente las siguientes propiedades de difracción de rayos X:
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10306099A EP2439192A1 (en) | 2010-10-07 | 2010-10-07 | Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR083360A1 true AR083360A1 (es) | 2013-02-21 |
Family
ID=43558332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110103726A AR083360A1 (es) | 2010-10-07 | 2011-10-11 | Metodo para la preparacion de acido (3s,3s’) 4,4’-disulfanodiilbis-(3-aminobutano-1-sulfonico) y su trihidrato cristalino |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9187418B2 (es) |
| EP (3) | EP2439192A1 (es) |
| JP (1) | JP5921556B2 (es) |
| KR (2) | KR101893894B1 (es) |
| CN (1) | CN103228624B (es) |
| AR (1) | AR083360A1 (es) |
| AU (1) | AU2011311483B2 (es) |
| BR (2) | BR112013008404B1 (es) |
| CA (2) | CA2813834C (es) |
| CY (2) | CY1120859T1 (es) |
| DK (2) | DK3395796T3 (es) |
| EA (1) | EA021612B1 (es) |
| ES (2) | ES2903434T3 (es) |
| HR (2) | HRP20220031T1 (es) |
| HU (2) | HUE040484T2 (es) |
| IL (1) | IL225557A (es) |
| LT (2) | LT3395796T (es) |
| MX (1) | MX2013003863A (es) |
| NZ (1) | NZ608971A (es) |
| PL (2) | PL2625163T3 (es) |
| PT (2) | PT3395796T (es) |
| RS (2) | RS57670B1 (es) |
| SI (2) | SI2625163T1 (es) |
| TW (1) | TWI532710B (es) |
| WO (1) | WO2012045849A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2439192A1 (en) | 2010-10-07 | 2012-04-11 | Quantum Genomics | Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) |
| EP2722327A1 (en) | 2012-10-22 | 2014-04-23 | Quantum Genomics | Crystalline phase of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) with L-lysine |
| US10501426B1 (en) | 2019-01-11 | 2019-12-10 | King Saud University | Synthesis of thiazole derivative as anticancer and anti-antibiotics resistant bacteria agent |
| TW202100146A (zh) | 2019-03-11 | 2021-01-01 | 法商量子基因科技有限公司 | 用於治療高血壓或心衰竭的化合物及包含其之組成物 |
| CN111892557B (zh) * | 2019-05-05 | 2022-11-08 | 河北圣泰材料股份有限公司 | 哌嗪类成膜离子液体的合成方法 |
| WO2022225712A1 (en) * | 2021-04-22 | 2022-10-27 | Teva Pharmaceuticals International Gmbh | Solid state forms of firibastat and processes for preparation thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5596095A (en) * | 1994-12-12 | 1997-01-21 | Procept, Inc. | Formation and utility of sulfonic acid protecting groups |
| ES2309336T3 (es) | 2002-07-16 | 2008-12-16 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Derivados de 4,4-ditiobis-(3-aminobutano-1-sulfanatos) nuevos y composiciones que los contienen. |
| FR2858617A1 (fr) * | 2003-08-06 | 2005-02-11 | Inst Nat Sante Rech Med | Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant |
| CN101845003A (zh) * | 2010-01-29 | 2010-09-29 | 华东理工大学 | N-三(羟甲基)甲基-3-氨基丙磺酸化合物及其制备方法 |
| EP2439192A1 (en) | 2010-10-07 | 2012-04-11 | Quantum Genomics | Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) |
-
2010
- 2010-10-07 EP EP10306099A patent/EP2439192A1/en not_active Withdrawn
-
2011
- 2011-10-06 TW TW100136334A patent/TWI532710B/zh active
- 2011-10-07 KR KR1020187008022A patent/KR101893894B1/ko active IP Right Grant
- 2011-10-07 SI SI201131578T patent/SI2625163T1/sl unknown
- 2011-10-07 PL PL11769843T patent/PL2625163T3/pl unknown
- 2011-10-07 RS RS20181090A patent/RS57670B1/sr unknown
- 2011-10-07 DK DK18177972.9T patent/DK3395796T3/da active
- 2011-10-07 HU HUE11769843A patent/HUE040484T2/hu unknown
- 2011-10-07 EA EA201300440A patent/EA021612B1/ru unknown
- 2011-10-07 HU HUE18177972A patent/HUE058031T2/hu unknown
- 2011-10-07 AU AU2011311483A patent/AU2011311483B2/en active Active
- 2011-10-07 JP JP2013532214A patent/JP5921556B2/ja active Active
- 2011-10-07 RS RS20211589A patent/RS62838B1/sr unknown
- 2011-10-07 KR KR1020137011888A patent/KR101869366B1/ko active IP Right Grant
- 2011-10-07 PL PL18177972T patent/PL3395796T3/pl unknown
- 2011-10-07 SI SI201132028T patent/SI3395796T1/sl unknown
- 2011-10-07 US US13/878,003 patent/US9187418B2/en active Active
- 2011-10-07 WO PCT/EP2011/067524 patent/WO2012045849A1/en active Application Filing
- 2011-10-07 LT LTEP18177972.9T patent/LT3395796T/lt unknown
- 2011-10-07 NZ NZ608971A patent/NZ608971A/en unknown
- 2011-10-07 BR BR112013008404-9A patent/BR112013008404B1/pt active IP Right Grant
- 2011-10-07 CA CA2813834A patent/CA2813834C/en active Active
- 2011-10-07 PT PT181779729T patent/PT3395796T/pt unknown
- 2011-10-07 EP EP18177972.9A patent/EP3395796B1/en active Active
- 2011-10-07 MX MX2013003863A patent/MX2013003863A/es active IP Right Grant
- 2011-10-07 PT PT11769843T patent/PT2625163T/pt unknown
- 2011-10-07 ES ES18177972T patent/ES2903434T3/es active Active
- 2011-10-07 EP EP11769843.1A patent/EP2625163B1/en active Active
- 2011-10-07 ES ES11769843.1T patent/ES2689246T3/es active Active
- 2011-10-07 HR HRP20220031TT patent/HRP20220031T1/hr unknown
- 2011-10-07 CA CA3016057A patent/CA3016057C/en active Active
- 2011-10-07 LT LTEP11769843.1T patent/LT2625163T/lt unknown
- 2011-10-07 DK DK11769843.1T patent/DK2625163T3/en active
- 2011-10-07 BR BR122021023430-2A patent/BR122021023430B1/pt active IP Right Grant
- 2011-10-07 CN CN201180056371.6A patent/CN103228624B/zh active Active
- 2011-10-11 AR ARP110103726A patent/AR083360A1/es active IP Right Grant
-
2013
- 2013-04-04 IL IL225557A patent/IL225557A/en active IP Right Grant
-
2015
- 2015-10-27 US US14/923,615 patent/US9340497B2/en active Active
-
2018
- 2018-09-07 HR HRP20181437TT patent/HRP20181437T1/hr unknown
- 2018-09-19 CY CY181100970T patent/CY1120859T1/el unknown
-
2022
- 2022-01-13 CY CY20221100031T patent/CY1124919T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR083360A1 (es) | Metodo para la preparacion de acido (3s,3s’) 4,4’-disulfanodiilbis-(3-aminobutano-1-sulfonico) y su trihidrato cristalino | |
| ES2498519T3 (es) | Un procedimiento para la fabricación de SNAC (SALCAPROZATO SÓDICO) | |
| BRPI0507783A (pt) | composição de tiol-éster processo para a produção de uma composição de tiol-éster, composição de hidroxi tiol-éster, processo para a produção de uma composição de hidróxi tiol-éster, composição de tiol-éster reticulada, processo para a produção de uma composição de tiol-éster reticulada, material fertilizante de liberação controlada e processo para produção do material fertilizante de liberação controlada | |
| ES2563323T3 (es) | Procedimiento para la preparación de un sólido cristalino a partir de derivados de ácido glicin-N,N-diacético | |
| BRPI0822106A2 (pt) | "processo para preparação de ácido metacrílico de alta pureza." | |
| ITMI20081164A1 (it) | Processo per la produzione di esteri dell'acido levulinico da biomasse | |
| WO2009040517A3 (en) | Methods of synthesis of certain hydroxamic acid compounds | |
| BRPI1006031A2 (pt) | processo de síntese de um ômega-aminoácido(éster) | |
| IT1401911B1 (it) | Processo per la sintesi di acido 2,5-furandicarbossilico | |
| BR112012020596A8 (pt) | substrato para a imobilização de substâncias funcionais e processo para preparar o mesmo. | |
| MX2013002149A (es) | Nuevo proceso para la preparacion de intermediarios utiles para la elaboracion de inhibidores de nep. | |
| ATE537136T1 (de) | Neues verfahren zur herstellung von säurechloriden | |
| BR112013004164A2 (pt) | processo para a preparação de intermediários para a produção de inibidores da nep | |
| CL2011001405A1 (es) | Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina. | |
| BR112013003154A2 (pt) | processo e dispositivo para estabilizar o resfriamento e desumidificação de reboco de gesso | |
| CY1117933T1 (el) | Συνθεσεις ξηρας ψυξης toy fgf-18 | |
| BR112018005075B8 (pt) | Processo para preparar pelo menos um metacrilato de alquila e ácido metacrílico | |
| EA201290872A1 (ru) | Способ получения бензоксаборолов | |
| BR112012007554A2 (pt) | método para a fabricação de ácidos amino hidróxi disfofônico | |
| ES2603227T3 (es) | Proceso para la preparación de compuestos cetólidos | |
| Inoue et al. | Growth of ring-shaped microtubule assemblies through stepwise active self-organisation | |
| EA200900732A1 (ru) | Кристаллическая калиевая соль аналогов липоксина а | |
| EA201300647A1 (ru) | Оптимизированный синтез чистых неполиморфных кристаллических жёлчных кислот с заданным размером частиц | |
| AR060189A1 (es) | Sales de malato y polimorfos de acido (3s, 5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolincarboxilico | |
| BR112012013272A2 (pt) | processo para a polimerização em massa do lactídeo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |