CY1117933T1 - Συνθεσεις ξηρας ψυξης toy fgf-18 - Google Patents
Συνθεσεις ξηρας ψυξης toy fgf-18Info
- Publication number
- CY1117933T1 CY1117933T1 CY20161100564T CY161100564T CY1117933T1 CY 1117933 T1 CY1117933 T1 CY 1117933T1 CY 20161100564 T CY20161100564 T CY 20161100564T CY 161100564 T CY161100564 T CY 161100564T CY 1117933 T1 CY1117933 T1 CY 1117933T1
- Authority
- CY
- Cyprus
- Prior art keywords
- fgf
- compositions
- toy
- cooling compositions
- dry cooling
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η εφεύρεση αφορά σε ένα πεδίο των φαρμακευτικών συνθέσεων. Πιο συγκεκριμένα, αφορά στις συνθέσεις ξηράς ψύξης της ένωσης Παράγοντα Ανάπτυξης Ινοβλαστών 18 (FGF-18) και τις μεθόδους παραγωγής των εν λόγω συνθέσεων. Οι συνθέσεις ξηράς ψύξης σύμφωνα με την εφεύρεση είναι σταθερές κατά την αποθήκευση για ένα κατάλληλο χρονικό διάστημα. Μπορούν να χρησιμοποιηθούν, μετά από ανασύσταση, για τη θεραπεία των διαταραχών των χόνδρων όπως είναι η οστεοαρθρίτιδα ή ο τραυματισμός των χόνδρων.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11170437 | 2011-06-17 | ||
US201161499216P | 2011-06-21 | 2011-06-21 | |
PCT/EP2012/061495 WO2012172072A1 (en) | 2011-06-17 | 2012-06-15 | Freeze-dried formulations of fgf-18 |
EP12728509.6A EP2720710B1 (en) | 2011-06-17 | 2012-06-15 | Freeze-dried formulations of fgf-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117933T1 true CY1117933T1 (el) | 2017-05-17 |
Family
ID=47356563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100564T CY1117933T1 (el) | 2011-06-17 | 2016-06-22 | Συνθεσεις ξηρας ψυξης toy fgf-18 |
Country Status (31)
Country | Link |
---|---|
US (2) | US9326944B2 (el) |
EP (2) | EP3056211A1 (el) |
JP (1) | JP5981538B2 (el) |
KR (1) | KR102019520B1 (el) |
CN (2) | CN107715104A (el) |
AR (1) | AR086956A1 (el) |
AU (1) | AU2012268987B2 (el) |
BR (1) | BR112013032400B1 (el) |
CA (1) | CA2836667C (el) |
CL (1) | CL2013003618A1 (el) |
CO (1) | CO6940377A2 (el) |
CY (1) | CY1117933T1 (el) |
DK (1) | DK2720710T3 (el) |
EA (1) | EA024937B1 (el) |
EC (1) | ECSP14013157A (el) |
ES (1) | ES2575732T3 (el) |
HR (1) | HRP20160566T1 (el) |
HU (1) | HUE028355T2 (el) |
IL (1) | IL229977A (el) |
MX (1) | MX338017B (el) |
MY (1) | MY170630A (el) |
PE (1) | PE20141265A1 (el) |
PL (1) | PL2720710T3 (el) |
PT (1) | PT2720710E (el) |
RS (1) | RS54875B1 (el) |
SG (1) | SG195021A1 (el) |
SI (1) | SI2720710T1 (el) |
TW (1) | TWI527590B (el) |
UA (1) | UA113174C2 (el) |
WO (1) | WO2012172072A1 (el) |
ZA (1) | ZA201308698B (el) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI527590B (zh) * | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Fgf-18之凍乾調配物 |
SG11201604972TA (en) | 2013-12-24 | 2016-07-28 | Ares Trading Sa | Fgf-18 formulation in alginate/collagen hydrogels |
CN107921095A (zh) * | 2015-08-13 | 2018-04-17 | 默克专利有限公司 | 包含fgf‑18化合物的复方组合物 |
FI3706710T3 (fi) * | 2017-11-10 | 2024-07-08 | Novartis Ag | Pitkäkestoisesti vapautuvia formulaatioita nivelensisäisiin käyttötarkoituksiin |
CN109836487B (zh) * | 2019-03-01 | 2022-06-17 | 重庆派金生物科技有限公司 | 一种人成纤维细胞生长因子18及其可溶性重组表达方法、制备方法、制剂和应用 |
CN112121150A (zh) * | 2019-06-24 | 2020-12-25 | 杭州生物医药创新研究中心 | 一种成纤维细胞生长因子10冻干粉 |
CN113304063A (zh) * | 2021-04-23 | 2021-08-27 | 四川省恩乐生物工程有限公司 | 一种用于肌肤美容抗衰老的组合物及其制备方法 |
CN118310835A (zh) * | 2024-04-16 | 2024-07-09 | 杭州百凌生物科技有限公司 | 一种质控品冻干粉及其制备方法和应用 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
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US5217954A (en) * | 1990-04-04 | 1993-06-08 | Scios Nova Inc. | Formulations for stabilizing fibroblast growth factor |
GB9015824D0 (en) | 1990-07-18 | 1990-09-05 | Erba Carlo Spa | Stable pharmaceutical compositions containing a fibroblast growth factor |
AU716785B2 (en) * | 1995-07-27 | 2000-03-09 | Genentech Inc. | Stabile isotonic lyophilized protein formulation |
US20010056066A1 (en) * | 1996-07-26 | 2001-12-27 | Smithkline Beecham Corporation | Method of treating immune cell mediated systemic diseases |
IL129379A (en) | 1996-10-16 | 2008-12-29 | Zymogenetics Inc | Fibroblast growth factor homologues |
CN1184673A (zh) * | 1996-12-13 | 1998-06-17 | 中国医科大学 | Fgf粗提多肽生长因子混合物及其提取工艺 |
AU6411199A (en) | 1998-10-13 | 2000-05-01 | Chiron Corporation | Angiogenically effective unit dose of fgf and method of administering |
JP5209161B2 (ja) | 1999-12-02 | 2013-06-12 | ザイモジェネティクス, インコーポレイテッド | 腺維芽細胞成長受容体−3又は−2を発現する細胞を標的化するための方法 |
CN1303714A (zh) * | 2000-01-13 | 2001-07-18 | 重庆多泰制药有限公司 | Ii型胶原蛋白口服胃溶制剂 |
AU2001286996A1 (en) * | 2000-08-31 | 2002-03-13 | Chiron Corporation | Stabilized fgf formulations containing reducing agents |
MXPA04000747A (es) * | 2001-07-25 | 2004-07-08 | Protein Desing Labs Inc | Formulacion farmaceutica liofilizada estable de anticuerpos igg. |
DE10204792A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
EP1551426B1 (en) * | 2002-10-07 | 2014-06-25 | ZymoGenetics, Inc. | Methods of administering fgf18 |
JP4607010B2 (ja) | 2003-02-28 | 2011-01-05 | 中外製薬株式会社 | タンパク質含有安定化製剤 |
CA2567309A1 (en) * | 2004-06-01 | 2005-12-15 | Ares Trading S.A. | Method of stabilizing proteins |
JP5948627B2 (ja) * | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | 線維芽細胞成長因子(fgf)のリモデリングと糖質ペグ化 |
DK1828239T3 (da) | 2004-12-10 | 2011-12-19 | Zymogenetics Inc | FGF18-produktion i prokaryote værter |
PL1962886T6 (pl) * | 2005-12-20 | 2023-03-13 | Bristol-Myers Squibb Company | Stabilne formulacje białkowe |
JP4729740B2 (ja) * | 2006-01-11 | 2011-07-20 | 独立行政法人産業技術総合研究所 | 受容体特異性を変化させたミュータント増殖因子およびそれを含有する医薬組成物 |
SI1986612T1 (sl) | 2006-02-07 | 2013-01-31 | Shire Human Genetic Therapies, Inc. | Stabilizirana spojina glukocerebrosidaze |
AU2007287510B2 (en) | 2006-08-25 | 2012-08-30 | Ares Trading S.A. | Treatment of cartilage disorders with FGF-18 |
CN101663046B (zh) * | 2007-03-30 | 2017-07-28 | Ambrx公司 | 经修饰fgf‑21多肽和其用途 |
CN104163864B (zh) * | 2007-03-30 | 2017-08-01 | Ambrx公司 | 经修饰fgf‑21多肽和其用途 |
CN101181280B (zh) * | 2007-11-23 | 2010-07-14 | 深圳万乐药业有限公司 | 吡柔比星冻干制剂及其制备方法 |
RS53551B1 (en) * | 2007-12-21 | 2015-02-27 | F. Hoffmann La Roche Ag | ANTIBODY FORMULATION |
TWI527590B (zh) * | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Fgf-18之凍乾調配物 |
-
2012
- 2012-06-11 TW TW101120864A patent/TWI527590B/zh active
- 2012-06-15 CN CN201710984784.XA patent/CN107715104A/zh active Pending
- 2012-06-15 SG SG2013085162A patent/SG195021A1/en unknown
- 2012-06-15 BR BR112013032400-7A patent/BR112013032400B1/pt active IP Right Grant
- 2012-06-15 SI SI201230600A patent/SI2720710T1/sl unknown
- 2012-06-15 KR KR1020137034615A patent/KR102019520B1/ko active IP Right Grant
- 2012-06-15 ES ES12728509.6T patent/ES2575732T3/es active Active
- 2012-06-15 US US14/126,937 patent/US9326944B2/en active Active
- 2012-06-15 EA EA201490032A patent/EA024937B1/ru not_active IP Right Cessation
- 2012-06-15 PE PE2013002832A patent/PE20141265A1/es not_active Application Discontinuation
- 2012-06-15 AU AU2012268987A patent/AU2012268987B2/en active Active
- 2012-06-15 DK DK12728509.6T patent/DK2720710T3/en active
- 2012-06-15 CA CA2836667A patent/CA2836667C/en active Active
- 2012-06-15 MY MYPI2013702439A patent/MY170630A/en unknown
- 2012-06-15 RS RS20160453A patent/RS54875B1/sr unknown
- 2012-06-15 CN CN201280029683.2A patent/CN103619347A/zh active Pending
- 2012-06-15 JP JP2014515216A patent/JP5981538B2/ja active Active
- 2012-06-15 AR ARP120102140A patent/AR086956A1/es not_active Application Discontinuation
- 2012-06-15 HU HUE12728509A patent/HUE028355T2/en unknown
- 2012-06-15 PT PT127285096T patent/PT2720710E/pt unknown
- 2012-06-15 EP EP16161448.2A patent/EP3056211A1/en not_active Withdrawn
- 2012-06-15 WO PCT/EP2012/061495 patent/WO2012172072A1/en active Application Filing
- 2012-06-15 PL PL12728509.6T patent/PL2720710T3/pl unknown
- 2012-06-15 UA UAA201314452A patent/UA113174C2/uk unknown
- 2012-06-15 MX MX2013014894A patent/MX338017B/es active IP Right Grant
- 2012-06-15 EP EP12728509.6A patent/EP2720710B1/en active Active
-
2013
- 2013-11-20 ZA ZA2013/08698A patent/ZA201308698B/en unknown
- 2013-12-17 CL CL2013003618A patent/CL2013003618A1/es unknown
- 2013-12-17 IL IL229977A patent/IL229977A/en active IP Right Grant
-
2014
- 2014-01-15 CO CO14006968A patent/CO6940377A2/es unknown
- 2014-01-17 EC EC2014013157A patent/ECSP14013157A/es unknown
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2016
- 2016-04-26 US US15/138,240 patent/US20160228374A1/en not_active Abandoned
- 2016-05-27 HR HRP20160566TT patent/HRP20160566T1/hr unknown
- 2016-06-22 CY CY20161100564T patent/CY1117933T1/el unknown
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