CY1120969T1 - Παραγωγα κινοξαλινης χρησιμα ως τροποποιητες fgfr κινασης - Google Patents
Παραγωγα κινοξαλινης χρησιμα ως τροποποιητες fgfr κινασηςInfo
- Publication number
- CY1120969T1 CY1120969T1 CY181101347T CY181101347T CY1120969T1 CY 1120969 T1 CY1120969 T1 CY 1120969T1 CY 181101347 T CY181101347 T CY 181101347T CY 181101347 T CY181101347 T CY 181101347T CY 1120969 T1 CY1120969 T1 CY 1120969T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cinoxaline
- fgfr
- products useful
- compounds
- mode modifiers
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αναφέρεται σε νέες ενώσεις παραγώγου κινοξαλίνης του Χημικού Τύπου (I), σε φαρμακευτικές συνθέσεις που περιλαμβάνουν τις εν λόγω ενώσεις, σε μεθόδους για την παρασκευή των εν λόγω ενώσεων και στη χρήση των εν λόγω ενώσεων για τη θεραπεία ασθενειών όπως ο καρκίνος.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14161820 | 2014-03-26 | ||
PCT/EP2015/056507 WO2015144803A1 (en) | 2014-03-26 | 2015-03-26 | Quinoxaline derivatives useful as fgfr kinase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1120969T1 true CY1120969T1 (el) | 2019-12-11 |
Family
ID=50389854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY181101347T CY1120969T1 (el) | 2014-03-26 | 2018-12-17 | Παραγωγα κινοξαλινης χρησιμα ως τροποποιητες fgfr κινασης |
Country Status (37)
Country | Link |
---|---|
US (2) | US9902714B2 (el) |
EP (1) | EP3122742B1 (el) |
JP (1) | JP6625551B2 (el) |
KR (1) | KR102469506B1 (el) |
CN (1) | CN106459010B (el) |
AP (1) | AP2016009536A0 (el) |
AR (1) | AR099854A1 (el) |
AU (1) | AU2015238300C1 (el) |
BR (1) | BR112016022060B1 (el) |
CA (1) | CA2943683A1 (el) |
CL (1) | CL2016002382A1 (el) |
CR (1) | CR20160501A (el) |
CY (1) | CY1120969T1 (el) |
DK (1) | DK3122742T3 (el) |
EA (1) | EA032145B1 (el) |
ES (1) | ES2702450T3 (el) |
HR (1) | HRP20182073T1 (el) |
HU (1) | HUE041738T2 (el) |
IL (1) | IL247658B (el) |
JO (1) | JO3512B1 (el) |
LT (1) | LT3122742T (el) |
MA (1) | MA39783B1 (el) |
MX (1) | MX2016012446A (el) |
MY (1) | MY194074A (el) |
NI (1) | NI201600144A (el) |
NZ (1) | NZ724907A (el) |
PH (1) | PH12016501898A1 (el) |
PL (1) | PL3122742T3 (el) |
PT (1) | PT3122742T (el) |
RS (1) | RS58088B1 (el) |
SG (1) | SG11201607961QA (el) |
SI (1) | SI3122742T1 (el) |
TR (1) | TR201819138T4 (el) |
TW (1) | TWI686391B (el) |
UA (1) | UA117958C2 (el) |
WO (1) | WO2015144803A1 (el) |
ZA (1) | ZA201606942B (el) |
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GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
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GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
CN105764905B (zh) | 2013-11-26 | 2019-06-07 | 豪夫迈·罗氏有限公司 | 新的八氢-环丁二烯并[1,2-c;3,4-c’]二吡咯-2基 |
EA031804B1 (ru) | 2014-02-03 | 2019-02-28 | Вайтаи Фармасьютиклз, Инк. | Дигидропирролопиридиновые ингибиторы ror-гамма |
PL3122750T3 (pl) | 2014-03-26 | 2020-03-31 | F.Hoffmann-La Roche Ag | Związki bicykliczne jako inhibitory wytwarzania autotaksyny (ATX) i kwasu lizofosfatydowego (LPA) |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
HUE053653T2 (hu) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | FGFR inhibitor és IGF1R inhibitor kombinációi |
EP3848034A1 (en) | 2014-03-26 | 2021-07-14 | Astex Therapeutics Limited | Cmet-inhibitors for use in delaying the emergence in resistance to fgfr inhibitors |
EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
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