MA39783B1 - Dérivés de quinoxaline utiles en tant que modulateurs de la fgfr kinase - Google Patents

Dérivés de quinoxaline utiles en tant que modulateurs de la fgfr kinase

Info

Publication number
MA39783B1
MA39783B1 MA39783A MA39783A MA39783B1 MA 39783 B1 MA39783 B1 MA 39783B1 MA 39783 A MA39783 A MA 39783A MA 39783 A MA39783 A MA 39783A MA 39783 B1 MA39783 B1 MA 39783B1
Authority
MA
Morocco
Prior art keywords
modulators
derivatives useful
quinoxaline derivatives
fgfr kinase
compounds
Prior art date
Application number
MA39783A
Other languages
English (en)
Other versions
MA39783A (fr
Inventor
Wim Vermeulen
Steven Anna Hostyn
Filip Albert Celine Cuyckens
Russell Mark Jones
Diego Fernando Domenico Broggini
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50389854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA39783(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of MA39783A publication Critical patent/MA39783A/fr
Publication of MA39783B1 publication Critical patent/MA39783B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés dérivés de quinoxaline de formule (i), des compositions pharmaceutiques comprenant lesdits composés, des procédés de préparation de ces composés et d'utilisation de ces composés dans le traitement de maladies, par ex. Cancer.
MA39783A 2014-03-26 2015-03-26 Dérivés de quinoxaline utiles en tant que modulateurs de la fgfr kinase MA39783B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14161820 2014-03-26
PCT/EP2015/056507 WO2015144803A1 (fr) 2014-03-26 2015-03-26 Dérivés de quinoxaline utiles en tant que modulateurs de la kinase fgfr
EP15720269.8A EP3122742B1 (fr) 2014-03-26 2015-03-26 Dérivés de quinoxaline utiles en tant que modulateurs de la fgfr kinase

Publications (2)

Publication Number Publication Date
MA39783A MA39783A (fr) 2017-02-01
MA39783B1 true MA39783B1 (fr) 2018-12-31

Family

ID=50389854

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39783A MA39783B1 (fr) 2014-03-26 2015-03-26 Dérivés de quinoxaline utiles en tant que modulateurs de la fgfr kinase

Country Status (37)

Country Link
US (2) US9902714B2 (fr)
EP (1) EP3122742B1 (fr)
JP (1) JP6625551B2 (fr)
KR (1) KR102469506B1 (fr)
CN (1) CN106459010B (fr)
AP (1) AP2016009536A0 (fr)
AR (1) AR099854A1 (fr)
AU (1) AU2015238300C1 (fr)
BR (1) BR112016022060B1 (fr)
CA (1) CA2943683A1 (fr)
CL (1) CL2016002382A1 (fr)
CR (1) CR20160501A (fr)
CY (1) CY1120969T1 (fr)
DK (1) DK3122742T3 (fr)
EA (1) EA032145B1 (fr)
ES (1) ES2702450T3 (fr)
HR (1) HRP20182073T1 (fr)
HU (1) HUE041738T2 (fr)
IL (1) IL247658B (fr)
JO (1) JO3512B1 (fr)
LT (1) LT3122742T (fr)
MA (1) MA39783B1 (fr)
MX (1) MX2016012446A (fr)
MY (1) MY194074A (fr)
NI (1) NI201600144A (fr)
NZ (1) NZ724907A (fr)
PH (1) PH12016501898B1 (fr)
PL (1) PL3122742T3 (fr)
PT (1) PT3122742T (fr)
RS (1) RS58088B1 (fr)
SG (1) SG11201607961QA (fr)
SI (1) SI3122742T1 (fr)
TR (1) TR201819138T4 (fr)
TW (1) TWI686391B (fr)
UA (1) UA117958C2 (fr)
WO (1) WO2015144803A1 (fr)
ZA (1) ZA201606942B (fr)

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