CY1119901T1 - Αναστολεις απομεθυλασων ιστονων - Google Patents

Αναστολεις απομεθυλασων ιστονων

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Publication number
CY1119901T1
CY1119901T1 CY20181100164T CY181100164T CY1119901T1 CY 1119901 T1 CY1119901 T1 CY 1119901T1 CY 20181100164 T CY20181100164 T CY 20181100164T CY 181100164 T CY181100164 T CY 181100164T CY 1119901 T1 CY1119901 T1 CY 1119901T1
Authority
CY
Cyprus
Prior art keywords
cancer
compounds
compositions
useful
treatment
Prior art date
Application number
CY20181100164T
Other languages
English (en)
Inventor
Toufike Kanouni
Jeffery Alan Stafford
James Marvin Veal
Michael Brennan Wallace
Original Assignee
Celgene Quanticel Research, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Quanticel Research, Inc. filed Critical Celgene Quanticel Research, Inc.
Publication of CY1119901T1 publication Critical patent/CY1119901T1/el

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται γενικά με συνθέσεις και μεθόδους για την αγωγή του καρκίνου και της νεοπλασματικής νόσου. Παρέχονται στο παρόν υποκατεστημένες ενώσεις παραγώγων 3-αμινοπυριδίνης, υποκατεστημένες ενώσεις 3-αμινοπυριδαζίνης, και φαρμακευτικές συνθέσεις που περιλαμβάνουν τις εν λόγω ενώσεις. Οι εν θέματι ενώσεις και συνθέσεις είναι χρήσιμες για την αναστολή των απομεθυλασών των ιστονών. Περαιτέρω, οι ενώσεις και οι συνθέσεις της εφεύρεσης είναι χρήσιμες για τη θεραπεία του καρκίνου, όπως του καρκίνου του προστάτη, του καρκίνου μαστού, του καρκίνου ουροδόχου κύστεως, καρκίνο πνεύμονα και/ή μελάνωμα και τα παρόμοια.
CY20181100164T 2012-12-19 2018-02-09 Αναστολεις απομεθυλασων ιστονων CY1119901T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261739521P 2012-12-19 2012-12-19
US201361792930P 2013-03-15 2013-03-15
PCT/US2013/076666 WO2014100463A1 (en) 2012-12-19 2013-12-19 Histone demethylase inhibitors

Publications (1)

Publication Number Publication Date
CY1119901T1 true CY1119901T1 (el) 2018-06-27

Family

ID=50931614

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100164T CY1119901T1 (el) 2012-12-19 2018-02-09 Αναστολεις απομεθυλασων ιστονων

Country Status (16)

Country Link
US (4) US9617242B2 (el)
EP (1) EP2934145B1 (el)
JP (1) JP6256772B2 (el)
AU (1) AU2013361255B2 (el)
CA (1) CA2895355A1 (el)
CY (1) CY1119901T1 (el)
DK (1) DK2934145T3 (el)
ES (1) ES2658597T3 (el)
HR (1) HRP20180067T1 (el)
HU (1) HUE037312T2 (el)
LT (1) LT2934145T (el)
PL (1) PL2934145T3 (el)
PT (1) PT2934145T (el)
RS (1) RS56821B1 (el)
SI (1) SI2934145T1 (el)
WO (1) WO2014100463A1 (el)

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Also Published As

Publication number Publication date
SI2934145T1 (en) 2018-03-30
LT2934145T (lt) 2018-02-26
JP6256772B2 (ja) 2018-01-10
AU2013361255A1 (en) 2015-07-09
DK2934145T3 (en) 2018-02-05
AU2013361255B2 (en) 2017-01-05
US9617242B2 (en) 2017-04-11
HUE037312T2 (hu) 2018-08-28
RS56821B1 (sr) 2018-04-30
ES2658597T3 (es) 2018-03-12
PT2934145T (pt) 2018-02-13
CA2895355A1 (en) 2014-06-26
US8969343B2 (en) 2015-03-03
US10040779B2 (en) 2018-08-07
HRP20180067T1 (hr) 2018-02-23
US20180305336A1 (en) 2018-10-25
EP2934145B1 (en) 2017-11-15
WO2014100463A1 (en) 2014-06-26
US20160060247A1 (en) 2016-03-03
EP2934145A1 (en) 2015-10-28
US10336727B2 (en) 2019-07-02
JP2016503799A (ja) 2016-02-08
US20170174656A1 (en) 2017-06-22
PL2934145T3 (pl) 2018-04-30
EP2934145A4 (en) 2016-06-29
US20140171432A1 (en) 2014-06-19

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