CY1123626T1 - Ετεροκυκλικοι αναστολεις πρωτεϊνικης κινασης - Google Patents

Ετεροκυκλικοι αναστολεις πρωτεϊνικης κινασης

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Publication number
CY1123626T1
CY1123626T1 CY20201101171T CY201101171T CY1123626T1 CY 1123626 T1 CY1123626 T1 CY 1123626T1 CY 20201101171 T CY20201101171 T CY 20201101171T CY 201101171 T CY201101171 T CY 201101171T CY 1123626 T1 CY1123626 T1 CY 1123626T1
Authority
CY
Cyprus
Prior art keywords
protein kinase
kinase inhibitors
heterocyclic
heterocyclic protein
tautomer
Prior art date
Application number
CY20201101171T
Other languages
English (en)
Inventor
Yong Xu
Benjamin Gary Brenning
Steven G. Kultgen
Xiaohui Liu
Michael Saunders
Koc-Kan Ho
Original Assignee
Sumitomo Dainippon Pharma Oncology, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Oncology, Inc. filed Critical Sumitomo Dainippon Pharma Oncology, Inc.
Publication of CY1123626T1 publication Critical patent/CY1123626T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει πρωτεϊνική κινάση η οποία διαθέτει μια από τις ακόλουθες δομές (Ι), (II) ή (III): ή ένα στερεοϊσομερές, προφάρμακο, ταυτομερές ή φαρμακευτικά αποδεκτό άλας αυτών, όπου τα R, R1, R2 και Χ είναι όπως ορίζονται στο παρόν. Επιπλέον, περιλαμβάνονται συνθέσεις και μέθοδοι χρησιμοποιώντας τα ίδια στη θεραπεία του καρκίνου, των αυτοάνοσων νόσων, των φλεγμονωδών νόσων και άλλων καταστάσεων που σχετίζονται με την Pim κινάση.
CY20201101171T 2011-07-21 2020-12-11 Ετεροκυκλικοι αναστολεις πρωτεϊνικης κινασης CY1123626T1 (el)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161510207P 2011-07-21 2011-07-21
US201161632834P 2011-07-21 2011-07-21
US201261632826P 2012-03-01 2012-03-01
US201261608028P 2012-03-07 2012-03-07
PCT/US2012/047685 WO2013013188A1 (en) 2011-07-21 2012-07-20 Heterocyclic protein kinase inhibitors
EP12815055.4A EP2734205B1 (en) 2011-07-21 2012-07-20 Heterocyclic protein kinase inhibitors

Publications (1)

Publication Number Publication Date
CY1123626T1 true CY1123626T1 (el) 2022-03-24

Family

ID=47558512

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201101171T CY1123626T1 (el) 2011-07-21 2020-12-11 Ετεροκυκλικοι αναστολεις πρωτεϊνικης κινασης

Country Status (11)

Country Link
US (5) US9416132B2 (el)
EP (3) EP3409278B8 (el)
JP (1) JP6105578B2 (el)
CY (1) CY1123626T1 (el)
DK (2) DK3409278T3 (el)
ES (2) ES2671748T3 (el)
HK (1) HK1198360A1 (el)
HU (1) HUE052198T2 (el)
PL (1) PL3409278T3 (el)
PT (1) PT3409278T (el)
WO (1) WO2013013188A1 (el)

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