UY31679A1 - Inhibidores de cinasa pim y metodos para su uso - Google Patents

Inhibidores de cinasa pim y metodos para su uso

Info

Publication number
UY31679A1
UY31679A1 UY031679A UY31679A UY31679A1 UY 31679 A1 UY31679 A1 UY 31679A1 UY 031679 A UY031679 A UY 031679A UY 31679 A UY31679 A UY 31679A UY 31679 A1 UY31679 A1 UY 31679A1
Authority
UY
Uruguay
Prior art keywords
pim kinase
methods
new compounds
kinase inhibitors
pharmaceutically acceptable
Prior art date
Application number
UY031679A
Other languages
English (en)
Inventor
Michelle Tetalman
Gisele Nishiguchi
Mika Lindvall
Matthew Burger
Lan Jiong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41055566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY31679(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of UY31679A1 publication Critical patent/UY31679A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención se refiere a nuevos compuestos de las formulas I y II, a sus tautómeros, esteroisómeros y polimorfos, y a las sales farmacéuticamente aceptables, ésteres, metabolitos o profármacos de los mismos, a composiciones de los nuevos compuestos junto con vehículos farmacéuticamente aceptables, y al uso de los nuevos compuestos, ya sea solos o bien en combinación con cuando menos un agente terapéutico adicional, en la inhibición de la actividad de la cinasa Pim y/o en la profilaxis o el tratamiento de cáncer.
UY031679A 2008-03-03 2009-02-27 Inhibidores de cinasa pim y metodos para su uso UY31679A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3335908P 2008-03-03 2008-03-03

Publications (1)

Publication Number Publication Date
UY31679A1 true UY31679A1 (es) 2009-09-30

Family

ID=41055566

Family Applications (1)

Application Number Title Priority Date Filing Date
UY031679A UY31679A1 (es) 2008-03-03 2009-02-27 Inhibidores de cinasa pim y metodos para su uso

Country Status (21)

Country Link
EP (2) EP2596790B1 (es)
JP (1) JP5412448B2 (es)
KR (1) KR20100120709A (es)
CN (2) CN104098559A (es)
AR (1) AR070531A1 (es)
AU (1) AU2009221134B2 (es)
BR (1) BRPI0909102A2 (es)
CA (1) CA2717388A1 (es)
CL (1) CL2009000483A1 (es)
CO (1) CO6290687A2 (es)
EA (1) EA201001412A1 (es)
EC (1) ECSP10010447A (es)
ES (2) ES2443496T3 (es)
IL (1) IL207865A0 (es)
MA (1) MA32135B1 (es)
MX (1) MX2010009739A (es)
PE (1) PE20091577A1 (es)
TW (1) TW200942536A (es)
UY (1) UY31679A1 (es)
WO (1) WO2009109576A1 (es)
ZA (1) ZA201006128B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101391900B1 (ko) 2005-12-13 2014-05-02 인사이트 코포레이션 야누스 키나아제 억제제로서의 헤테로아릴 치환된 피롤로［2,3-ｂ］피리딘 및 피롤로［2,3-ｂ］피리미딘
KR101549876B1 (ko) 2007-06-13 2015-09-03 인사이트 코포레이션 야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염
EA020136B1 (ru) * 2008-09-02 2014-08-29 Новартис Аг Производные пиколинамида в качестве ингибиторов киназы
ES2487542T3 (es) 2009-05-22 2014-08-21 Incyte Corporation Derivados de N-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de cinasas Janus
NZ596374A (en) 2009-05-22 2014-01-31 Incyte Corp 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
US9249145B2 (en) 2009-09-01 2016-02-02 Incyte Holdings Corporation Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
WO2011029802A1 (en) * 2009-09-08 2011-03-17 F. Hoffmann-La Roche Ag 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
US8435976B2 (en) 2009-09-08 2013-05-07 F. Hoffmann-La Roche 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
SI3050882T1 (en) 2010-03-10 2018-06-29 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives, as inhibitors of JAK1
EA201290957A1 (ru) * 2010-04-07 2013-04-30 Ф.Хоффманн-Ля Рош Аг Пиразол-4-илгетероциклилкарбоксамидные соединения и способы их применения
US9156827B2 (en) 2010-04-30 2015-10-13 The University Of Tokyo Anticancer agent
TWI499421B (zh) 2010-05-21 2015-09-11 Incyte Corp Ｊａｋ抑制劑的局部製劑
WO2012004217A1 (en) * 2010-07-06 2012-01-12 Novartis Ag Cyclic ether compounds useful as kinase inhibitors
JP5917544B2 (ja) 2010-11-19 2016-05-18 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｋ阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン
PE20140146A1 (es) 2010-11-19 2014-02-06 Incyte Corp Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
UY33930A (es) * 2011-03-04 2012-10-31 Novartis Ag Inhibidores novedosos de quinasas
EP2681197A1 (en) * 2011-03-04 2014-01-08 Novartis AG Tetrasubstituted cyclohexyl compounds as kinase inhibitors
CA2834166A1 (en) 2011-04-29 2012-11-01 Amgen Inc. Bicyclic pyridazine compounds as pim inhibitors
ES2560611T3 (es) 2011-06-20 2016-02-22 Incyte Holdings Corporation Derivados de fenil de azetidinilo, carboxamida de piridilo o pirazinilo como inhibidores de JAK
EP3812387A1 (en) 2011-07-21 2021-04-28 Sumitomo Dainippon Pharma Oncology, Inc. Heterocyclic protein kinase inhibitors
CN102924446B (zh) * 2011-08-11 2015-08-26 上海吉铠医药科技有限公司 Pim激酶抑制剂及其制备方法与在制药中的应用
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TWI570117B (zh) 2011-09-27 2017-02-11 赫孚孟拉羅股份公司 吡唑－４－基－雜環甲醯胺化合物及使用方法
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
MX2014014253A (es) * 2012-05-21 2015-02-17 Novartis Ag Novedosas n-piridinil-amidas sustituidas en el anillo como inhibidoras de cinasa.
WO2014033631A1 (en) * 2012-08-31 2014-03-06 Novartis Ag N-(3-pyridyl) biarylamides as kinase inhibitors
WO2014033630A1 (en) * 2012-08-31 2014-03-06 Novartis Ag Novel aminothiazole carboxamides as kinase inhibitors
ES2791648T3 (es) 2012-09-26 2020-11-05 Hoffmann La Roche Compuestos de pirazol-4-il-heterociclil-carboxamida con éter cíclico y procedimientos de uso
UA120834C2 (uk) 2012-11-15 2020-02-25 Інсайт Холдінгс Корпорейшн Лікарські форми руксолітинібу зі сповільненим вивільненням
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
RS60244B1 (sr) * 2013-01-15 2020-06-30 Incyte Holdings Corp Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze
CA3091179C (en) 2013-03-06 2023-01-17 Incyte Holdings Corporation Processes and intermediates for making a jak inhibitor
CN105579032A (zh) 2013-08-07 2016-05-11 因赛特公司 Jak1抑制剂的持续释放剂型
JP2016528298A (ja) 2013-08-23 2016-09-15 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
TW201718546A (zh) 2015-10-02 2017-06-01 英塞特公司 適用作pim激酶抑制劑之雜環化合物
AU2018335838B2 (en) * 2017-09-20 2022-06-30 Lead Discovery Center Gmbh Coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
MA51771B1 (fr) 2018-01-30 2022-03-31 Incyte Corp Procédés de préparation de (1-(3-fluoro-2-(trifluorométhyl)isonicotinyl)pipéridine-4-one)
SG11202009441PA (en) 2018-03-30 2020-10-29 Incyte Corp Treatment of hidradenitis suppurativa using jak inhibitors
CA3095580A1 (en) 2018-04-13 2019-10-17 Sumitomo Dainippon Pharma Oncology, Inc. Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer
CA3127502A1 (en) 2019-02-12 2020-08-20 Sumitomo Dainippon Pharma Oncology, Inc. Formulations comprising heterocyclic protein kinase inhibitors
CN110452164B (zh) * 2019-09-10 2022-07-22 上海皓鸿生物医药科技有限公司 Pim447关键中间体的制备方法
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005028467A1 (en) 2003-09-15 2005-03-31 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
TW200523252A (en) * 2003-10-31 2005-07-16 Takeda Pharmaceutical Pyridine compounds
JP2008543965A (ja) * 2005-06-28 2008-12-04 タケダ・ケンブリッジ・リミテッド 複素環式非ペプチドｇｎｒｈ拮抗薬
CN101370811A (zh) * 2005-11-10 2009-02-18 先灵公司 作为蛋白激酶抑制剂的咪唑并吡嗪化合物
MX2008013400A (es) * 2006-04-19 2008-11-10 Astellas Pharma Inc Derivado de azolcarboxamida.
PE20080928A1 (es) * 2006-10-31 2008-08-15 Schering Corp Derivados de anilinopiperazina como inhibidores de proteina quinasa
EP2078002B1 (en) * 2006-10-31 2013-08-28 Merck Sharp & Dohme Corp. 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors
WO2008054702A1 (en) * 2006-10-31 2008-05-08 Schering Corporation Anilinopiperazine derivatives and methods of use thereof
MX2009009304A (es) * 2007-03-01 2009-11-18 Novartis Ag Inhibidores de cinasa pim y metodos para su uso.

Also Published As

Publication number Publication date
EA201001412A1 (ru) 2011-06-30
CO6290687A2 (es) 2011-06-20
ZA201006128B (en) 2011-10-26
MX2010009739A (es) 2010-09-28
MA32135B1 (fr) 2011-03-01
CA2717388A1 (en) 2009-09-11
CN104098559A (zh) 2014-10-15
ECSP10010447A (es) 2010-10-30
AU2009221134B2 (en) 2012-02-23
JP2011513363A (ja) 2011-04-28
CN102015701A (zh) 2011-04-13
CN102015701B (zh) 2014-07-23
AR070531A1 (es) 2010-04-14
IL207865A0 (en) 2010-12-30
BRPI0909102A2 (pt) 2019-01-15
EP2262802A1 (en) 2010-12-22
AU2009221134A1 (en) 2009-09-11
EP2262802B1 (en) 2013-10-23
CL2009000483A1 (es) 2010-02-19
JP5412448B2 (ja) 2014-02-12
WO2009109576A1 (en) 2009-09-11
ES2562306T3 (es) 2016-03-03
ES2443496T3 (es) 2014-02-19
EP2596790B1 (en) 2015-12-09
KR20100120709A (ko) 2010-11-16
EP2596790A1 (en) 2013-05-29
TW200942536A (en) 2009-10-16
PE20091577A1 (es) 2009-11-05

Similar Documents

Publication Publication Date Title
CO6290687A2 (es) Inhibidores de cinasa pim y metodos para su uso
CR11757A (es) Compuestos de triazina como inhibidores mtor y quinasa pi3
CR11793A (es) 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas
EA201200049A1 (ru) 1,3-дизамещенные производные имидазолидин-2-она в качестве ингибиторов cyp 17
CR11518A (es) Compuestos de carbamoilo como inhibidores de dgat1 190
CU20110145A7 (es) Derivados de sulfonamida
CO6290683A2 (es) Compuestos de pirido imidazolinas heterociclicas y sus composiciones como inhibidores de c-met
CR20140544A (es) Compuestos para inhibir la progresión mitotica
UY31906A (es) Derivados de n-cicloalquil-3-fenilnicotinamida que inhiben pgds, sus composiciones, su uso para el tratamiento por ejemplo de afecciones alérgicas y respiratorias.
CR20120130A (es) Compuestos de benzoxepina inhibidores de la pi3k y métodos de uso
CO6410279A2 (es) Composición farmacéutica que comprende derivados de glucopiranosil difenilmetano, forma farmacéutica de la misma, procedimiento para su preparación y usos de la misma para el control glucémico mejorado en un paciente.
SV2011004077A (es) Derivados aminobutiricos sustituidos como inhibidores de neprilisina
ECSP10010510A (es) Compuestos del inhibidor de raf y métodos de uso de los mismos
ECSP088630A (es) Derivados de pirimidina utilizados como inhibidores de cinasa pi-3
DOP2009000159A (es) Inhibidores de la poli(adp-ribosa) polimerasa
EA200900924A1 (ru) Циклизованные производные как ингибиторы eg-5
UY33075A (es) Derivados de ciclohexano y usos de los mismos
UY31885A (es) Derivados de las 1, 3, 5-triazina-2, 4-diaminas-6-sustituidas-n-sustituidas y sales farmacéuticamente aceptables de los mismos, composiciones y aplicaciones.
EA201101435A1 (ru) Имидазотиадиазолы для применения в качестве ингибиторов киназ
PA8821301A1 (es) Inhibidores a base de hidroxamato de desacetilasas b
TW200800951A (en) Substituted imidazole compounds as KSP inhibitors
EA200900631A1 (ru) Замещённые пиразолы и триазолы, как ингибиторы кбв (кинезин-белок веретена)
CU20110113A7 (es) Lactamas como inhibidores beta secretasa
CL2023002486A1 (es) Compuestos heterocíclicos como inhibidores de delta-5 desaturasa y métodos de uso
CL2011001829A1 (es) 3'-n-desmetil-4''-o-(2-dietilaminoetanoil)-6-o-metil-9a-aza-9a-homoeritromicina a, sus sales y formas cristalinas 1, 2 y 3; proceso de preparacion; uso para tratar enfermedades inflamatorias; composicion farmaceutica; y composicion que ademas comprende otro compuesto activo.

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20180831