EA201001412A1 - Ингибиторы киназы pim и способы их применения - Google Patents

Ингибиторы киназы pim и способы их применения

Info

Publication number
EA201001412A1
EA201001412A1 EA201001412A EA201001412A EA201001412A1 EA 201001412 A1 EA201001412 A1 EA 201001412A1 EA 201001412 A EA201001412 A EA 201001412A EA 201001412 A EA201001412 A EA 201001412A EA 201001412 A1 EA201001412 A1 EA 201001412A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pim kinase
new compounds
methods
application
kinase inhibitors
Prior art date
Application number
EA201001412A
Other languages
English (en)
Inventor
Маттью Бургер
Цзион Лань
Мика Линдвалль
Джизеле Нишигучи
Мишелль Титалман
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41055566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201001412(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201001412A1 publication Critical patent/EA201001412A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

В заявке описаны новые соединения формул I и II, их таутомеры, стереоизомеры и полиморфные формы и фармацевтически приемлемые соли, сложные эфиры, метаболиты или пролекарства, композиции новых соединений вместе с фармацевтически приемлемыми носителями и применение этих новых соединений по отдельности или в комбинации по меньшей мере с одним дополнительным терапевтическим средством для ингибирования активности киназы PIM и/или профилактики или лечения рака.
EA201001412A 2008-03-03 2009-03-03 Ингибиторы киназы pim и способы их применения EA201001412A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3335908P 2008-03-03 2008-03-03
PCT/EP2009/052506 WO2009109576A1 (en) 2008-03-03 2009-03-03 Pim kinase inhibitors and methods of their use

Publications (1)

Publication Number Publication Date
EA201001412A1 true EA201001412A1 (ru) 2011-06-30

Family

ID=41055566

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001412A EA201001412A1 (ru) 2008-03-03 2009-03-03 Ингибиторы киназы pim и способы их применения

Country Status (21)

Country Link
EP (2) EP2262802B1 (ru)
JP (1) JP5412448B2 (ru)
KR (1) KR20100120709A (ru)
CN (2) CN104098559A (ru)
AR (1) AR070531A1 (ru)
AU (1) AU2009221134B2 (ru)
BR (1) BRPI0909102A2 (ru)
CA (1) CA2717388A1 (ru)
CL (1) CL2009000483A1 (ru)
CO (1) CO6290687A2 (ru)
EA (1) EA201001412A1 (ru)
EC (1) ECSP10010447A (ru)
ES (2) ES2443496T3 (ru)
IL (1) IL207865A0 (ru)
MA (1) MA32135B1 (ru)
MX (1) MX2010009739A (ru)
PE (1) PE20091577A1 (ru)
TW (1) TW200942536A (ru)
UY (1) UY31679A1 (ru)
WO (1) WO2009109576A1 (ru)
ZA (1) ZA201006128B (ru)

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Also Published As

Publication number Publication date
CN104098559A (zh) 2014-10-15
EP2596790B1 (en) 2015-12-09
KR20100120709A (ko) 2010-11-16
ES2562306T3 (es) 2016-03-03
JP2011513363A (ja) 2011-04-28
CN102015701B (zh) 2014-07-23
PE20091577A1 (es) 2009-11-05
MX2010009739A (es) 2010-09-28
AR070531A1 (es) 2010-04-14
BRPI0909102A2 (pt) 2019-01-15
CO6290687A2 (es) 2011-06-20
IL207865A0 (en) 2010-12-30
EP2262802A1 (en) 2010-12-22
UY31679A1 (es) 2009-09-30
AU2009221134B2 (en) 2012-02-23
ES2443496T3 (es) 2014-02-19
AU2009221134A1 (en) 2009-09-11
CL2009000483A1 (es) 2010-02-19
EP2262802B1 (en) 2013-10-23
CA2717388A1 (en) 2009-09-11
JP5412448B2 (ja) 2014-02-12
ZA201006128B (en) 2011-10-26
TW200942536A (en) 2009-10-16
MA32135B1 (fr) 2011-03-01
WO2009109576A1 (en) 2009-09-11
ECSP10010447A (es) 2010-10-30
EP2596790A1 (en) 2013-05-29
CN102015701A (zh) 2011-04-13

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