MA32272B1 - Inhibiteurs de raf de pyrazole [3,4-b]pyridine - Google Patents

Inhibiteurs de raf de pyrazole [3,4-b]pyridine

Info

Publication number
MA32272B1
MA32272B1 MA33203A MA33203A MA32272B1 MA 32272 B1 MA32272 B1 MA 32272B1 MA 33203 A MA33203 A MA 33203A MA 33203 A MA33203 A MA 33203A MA 32272 B1 MA32272 B1 MA 32272B1
Authority
MA
Morocco
Prior art keywords
raf
pyrazole
pyridine
inhibitors
compounds
Prior art date
Application number
MA33203A
Other languages
Arabic (ar)
English (en)
Inventor
Meese Jason De
Kateri A Ahrendt
Alexandre J Buckmelter
Jonas Grina
Joshua D Hansen
Ellen R Laird
Paul Lunghofer
David Moreno
Brad Newhouse
Li Ren
Jeongbeob Seo
Hongqi Tian
Steven Mark Wenglowsky
Bainian Feng
Janet Gunzner
Kim Malesky
Simon Mathieu
Joachim Rudolph
Zhaoyang Wen
Wendy B Young
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Publication of MA32272B1 publication Critical patent/MA32272B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Abstract

La présente invention concerne des composés de formule i qui sont utiles pour l'inhibition de kinases raf. La présente invention concerne des procédés d'utilisation de composés de formule i et des stéréo-isomères, tautomères, promédicaments et sels pharmaceutiquement acceptables de ceux-ci, pour le diagnostic, la prévention ou le traitement in vitro, in situ, et in vivo de tels troubles dans des cellules de mammifère, ou des états pathologiques associés.
MA33203A 2008-02-29 2010-09-24 Inhibiteurs de raf de pyrazole [3,4-b]pyridine MA32272B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3281308P 2008-02-29 2008-02-29
PCT/US2009/035381 WO2009111279A1 (fr) 2008-02-29 2009-02-27 Inhibiteurs de raf de pyrazole[3,4-b]pyridine

Publications (1)

Publication Number Publication Date
MA32272B1 true MA32272B1 (fr) 2011-05-02

Family

ID=40677552

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33203A MA32272B1 (fr) 2008-02-29 2010-09-24 Inhibiteurs de raf de pyrazole [3,4-b]pyridine

Country Status (19)

Country Link
US (1) US8394795B2 (fr)
EP (1) EP2265610B1 (fr)
JP (1) JP2011513331A (fr)
KR (1) KR20100117686A (fr)
CN (1) CN102149712A (fr)
AR (1) AR072657A1 (fr)
AU (1) AU2009222144A1 (fr)
BR (1) BRPI0908268A2 (fr)
CA (1) CA2716952A1 (fr)
CL (1) CL2009000448A1 (fr)
CR (1) CR11690A (fr)
EC (1) ECSP10010507A (fr)
ES (1) ES2400202T3 (fr)
IL (1) IL207845A0 (fr)
MA (1) MA32272B1 (fr)
MX (1) MX2010009411A (fr)
PE (1) PE20091623A1 (fr)
TW (1) TW200940539A (fr)
WO (1) WO2009111279A1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063888A2 (fr) 2006-11-22 2008-05-29 Plexxikon, Inc. Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées
NZ582772A (en) 2007-07-17 2012-06-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
ES2426092T3 (es) 2008-01-09 2013-10-21 Array Biopharma, Inc. 5H-Ciclopenta[d]pirimidinas como inhibidores de proteínas cinasas AKT
CL2009000447A1 (es) * 2008-02-29 2010-01-04 Array Biopharma Inc Y Genentech Inc Compuestos derivados de (1h-pirrolo{2,3-b}piridin-5-il)-sulfonamido-benzamida sustituida; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer, a travez de la inhibicion de raf.
CA2716949A1 (fr) * 2008-02-29 2009-09-11 Array Biopharma Inc. Derives de n-(6-aminopyridin-3-yl)-3-(sulfonamido) benzamide comme inhibiteurs de b-raf pour le traitement du cancer
JP2011513329A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド ＲＡＦ阻害化合物として使用されるイミダゾ［４，５−ｂ］ピリジン誘導体
EA031116B1 (ru) 2009-04-03 2018-11-30 Ф. Хоффманн-Ля Рош Аг КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ
GEP20135879B (en) * 2009-08-03 2013-07-10 Aziende Chimiche Riunite Angelini Francesco A C R A F S P A It Method of 1-benzyl-3-hydroxymethyl-1h-indazole preparation, derivatives thereof, and required magnesium intermediates
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
WO2011025938A2 (fr) * 2009-08-28 2011-03-03 Array Biopharma Inc. COMPOSÉS INHIBITEURS DE Raf ET LEURS PROCÉDÉS D'UTILISATION
US20120157452A1 (en) * 2009-08-28 2012-06-21 Genentech, Inc. 1h-pyrazolo[3,4-b] pyridine compounds for inhibiting raf kinase
MX2012005284A (es) 2009-11-06 2012-06-28 Plexxikon Inc Compuestos y metodos para la modulacion de cinasas. e indicaciones para ello.
US8937088B2 (en) 2011-01-06 2015-01-20 Astar Biotech Llc Ureas for the treatment and prevention of cancer
PT2672967T (pt) 2011-02-07 2018-12-07 Plexxikon Inc Compostos e métodos de modulação da quinase e suas indicações
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
MY193562A (en) 2011-08-01 2022-10-19 Genentech Inc Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
CA2846630A1 (fr) 2011-09-19 2013-03-28 Genentech, Inc. Polytherapies comportant des antagonistes de c-met et de b-raf
CN102491974B (zh) * 2011-12-12 2013-08-07 南京药石药物研发有限公司 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
WO2013127268A1 (fr) * 2012-03-02 2013-09-06 Genentech,Inc. Dérivés sulfonamides et sulfones amido-benzyliques
CA2872014A1 (fr) * 2012-05-08 2013-11-14 Lycera Corporation Tetrahydro[1,8]naphtyridine-sulfonamide et composes apparentes pour utilisation en tant qu'agonistes de ror.gamma. et dans le traitement d'une maladie
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
KR20210108502A (ko) 2012-08-17 2021-09-02 에프. 호프만-라 로슈 아게 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
JP2016509045A (ja) 2013-02-22 2016-03-24 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト がんを治療し、薬剤耐性を防止する方法
CA2906784C (fr) * 2013-03-15 2023-02-28 The Centre For Drug Research And Development Composes cytotoxiques et antimitotiques et leurs procedes d'utilisation
MX2015011899A (es) 2013-03-15 2016-05-05 Genentech Inc Metodos para el tratamiento de cáncer y prevención de resistencia a los fármacos para el cáncer.
AU2014274093B2 (en) 2013-05-30 2018-11-08 Plexxikon Inc. Compounds for kinase modulation, and indications therefor
TN2016000005A1 (en) * 2013-07-08 2017-07-05 Bayer Pharma AG Substituted pyrazolo-pyridinamines
KR20160055170A (ko) 2013-08-30 2016-05-17 암비트 바이오사이언시즈 코포레이션 바이아릴 아세트아미드 화합물 및 이의 사용 방법
CN107073121A (zh) 2014-06-13 2017-08-18 基因泰克公司 治疗及预防癌症药物抗性的方法
JP6673896B2 (ja) 2014-07-15 2020-03-25 ジェネンテック， インコーポレイテッド Ｐｄ−１軸結合アンタゴニスト及びｍｅｋ阻害剤を使用した癌を処置するための組成物
JP6636014B2 (ja) * 2014-09-12 2020-01-29 ノバルティス アーゲー Ｒａｆキナーゼ阻害剤としての化合物および組成物
PL3377107T3 (pl) 2015-11-19 2020-12-14 F. Hoffmann-La Roche Ag Sposoby leczenia nowotworu przy użyciu inhibitorów b-raf i inhibitorów immunologicznego punktu kontrolnego
WO2018146253A1 (fr) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pharmaceutiques pour le traitement de cancers associés à l'activation de la voie mapk
CA3079837A1 (fr) * 2017-11-01 2019-05-09 The Board Of Trustees Of The Leland Stanford Junior University Procede de detection d'analyte
JP7416716B2 (ja) 2017-12-28 2024-01-17 トラクト ファーマシューティカルズ インコーポレイテッド 円柱上皮幹細胞のための幹細胞培養系およびそれに関連した使用法
WO2020188015A1 (fr) 2019-03-21 2020-09-24 Onxeo Molécule dbait associée à un inhibiteur de kinase pour le traitement du cancer
CN110627691B (zh) * 2019-08-20 2022-03-25 中船(邯郸)派瑞特种气体股份有限公司 一种制备n-苯基-双(全氟烷基磺酰)亚胺的方法
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6121M (fr) * 1966-01-12 1968-06-17
NZ186175A (en) 1977-01-27 1980-03-05 Shionogi & Co Meta-sulphonamidobenzamide derivatives
US5800711A (en) * 1996-10-18 1998-09-01 Mdv Technologies, Inc. Process for the fractionation of polyoxyalkylene block copolymers
AU747705C (en) 1997-12-13 2004-09-23 Bristol-Myers Squibb Company Use of pyrazolo (3,4-b) pyridine as cyclin dependent kinase inhibitors
ATE328873T1 (de) 1997-12-22 2006-06-15 Bayer Pharmaceuticals Corp Hemmung von raf-kinase unter verwendung von aryl- und heteroarylsubstituierten heterocyclischen harnstoffen
TR200002618T2 (tr) 1997-12-22 2001-04-20 Bayer Corporation Sübstitüe edilmiş heterosiklik üreler kullanılarak raf kinazın inhibe edilmesi
TR200100874T2 (tr) 1997-12-22 2001-06-21 Bayer Corporation Simetrik ve simetrik olmayan sübstitüe edilmiş difenil üreler kullanılarak raf kinazın inhibe edilmesi
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2000041698A1 (fr) 1999-01-13 2000-07-20 Bayer Corporation DIPHENYLE UREES A SUBSTITUTION φ-CARBOXY ARYLE EN TANT QU'INHIBITEURS DE LA KINASE p38
WO2000042012A1 (fr) 1999-01-13 2000-07-20 Bayer Corporation DIPHENYLUREES A SUBSTITUANTS φ-CARBOXYARYLES, INHIBITRICES DE KINASE RAF
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
RU2319693C9 (ru) 1999-01-13 2008-08-20 Байер Копэрейшн Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты)
US6761824B2 (en) * 2000-08-17 2004-07-13 Reeve Lorraine E Process for the fractionation of polymers
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US20030207914A1 (en) 2001-04-20 2003-11-06 Bayer Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
GB0112348D0 (en) 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
US20020192289A1 (en) * 2001-06-18 2002-12-19 Ji Zheng Polymer gel for cancer treatment
GB0121490D0 (en) 2001-09-05 2001-10-24 Smithkline Beecham Plc Ciompounds
AU2003245700A1 (en) 2002-02-12 2003-09-04 Glaxo Group Limited Pyrazolopyridine derivatives
WO2003082272A1 (fr) 2002-03-29 2003-10-09 Chiron Corporation Benzazoles substitues et leur utilisation en tant qu'inhibiteurs de la kinase raf
WO2004084703A2 (fr) * 2003-03-24 2004-10-07 Biosphere Medical, Inc. Embolisation temporaire effectuee a l'aide de polymeres thermosensibles reversibles a action momentanee
PL1635835T3 (pl) 2003-06-13 2010-06-30 Novartis Ag Pochodne 2-aminopirymidyny jako inhibitory kinazy RAF
US7691886B2 (en) 2003-07-11 2010-04-06 Merck Patent Gmbh Benzimidazole derivatives as raf kinase inhibitors
EP1643991B1 (fr) 2003-07-11 2014-03-12 Merck Patent GmbH Benzimidazole carboxamides utilises en tant qu'inhibiteurs de la kinase raf
RU2356889C2 (ru) 2003-07-17 2009-05-27 Плекссикон, Инк. Соединения, являющиеся активными по отношению к рецепторам, активируемым пролифератором пероксисом
DE10337942A1 (de) 2003-08-18 2005-03-17 Merck Patent Gmbh Aminobenzimidazolderivate
DE10344223A1 (de) 2003-09-24 2005-04-21 Merck Patent Gmbh 1,3-Benzoxazolylderivate als Kinase-Inhibitoren
CN1863774B (zh) 2003-10-08 2010-12-15 Irm责任有限公司 用作蛋白激酶抑制剂的化合物和组合物
JP4755991B2 (ja) 2003-10-16 2011-08-24 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｒａｆキナーゼインヒビターとしての置換ベンゾアゾールおよびその使用
US20050084835A1 (en) 2003-10-16 2005-04-21 The Singing Machine Company, Inc. Karaoke system with built-in camera
EP1696920B8 (fr) 2003-12-19 2015-05-06 Plexxikon Inc. Composes et methodes de developpement de modulateurs de ret
DE102004009238A1 (de) 2004-02-26 2005-09-08 Merck Patent Gmbh Arylamid-Derivate
TW200616974A (en) 2004-07-01 2006-06-01 Astrazeneca Ab Chemical compounds
US20090118261A1 (en) 2004-08-31 2009-05-07 Astrazeneca Ab Quinazolinone derivatives and their use as b-raf inhibitors
JP2008511600A (ja) 2004-09-01 2008-04-17 アストラゼネカ アクチボラグ キナゾリン誘導体およびＢ−Ｒａｆ抑制剤としてそれらの使用
US20070054916A1 (en) 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
DE502005002697D1 (de) 2004-10-13 2008-03-13 Merck Patent Gmbh Als kinaseinhibitoren geeignete derivate des n,n'-diphenylharnstoffs
US7696224B2 (en) 2004-10-13 2010-04-13 Merck Patent Gmbh Phenylurea derivatives as inhibitors of tyrosine kinases for the treatment of tumour diseases
JP2008516939A (ja) 2004-10-15 2008-05-22 アストラゼネカ アクチボラグ 化学化合物
GB0423554D0 (en) 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
DE602005013819D1 (de) 2004-12-22 2009-05-20 Astrazeneca Ab Pyridincarbonsäureamidderivate zur verwendung als antikrebsmittel
CA2589779A1 (fr) * 2004-12-23 2006-06-29 F. Hoffmann-La Roche Ag Derives benzamides, leur fabrication et leur utilisation comme agents pharmaceutiques
WO2006071940A2 (fr) 2004-12-23 2006-07-06 Deciphera Pharmaceuticals, Llc Modulateurs d'enzymes et traitements
WO2006079791A1 (fr) 2005-01-25 2006-08-03 Astrazeneca Ab Composes chimiques
CN101106990B (zh) 2005-01-26 2010-12-08 Irm责任有限公司 用作蛋白激酶抑制剂的化合物和组合物
TW200639163A (en) 2005-02-04 2006-11-16 Genentech Inc RAF inhibitor compounds and methods
BRPI0606281A2 (pt) 2005-03-17 2009-06-09 Novartis Ag compostos orgánicos
WO2006124780A2 (fr) 2005-05-12 2006-11-23 Kalypsys, Inc. Inhibiteurs de la b-raf kinase
WO2006124731A2 (fr) 2005-05-12 2006-11-23 Irm Llc Composes et compositions utilise(e)s en tant qu'inhibiteurs de proteines-kinases
AU2006247757B2 (en) 2005-05-13 2009-08-27 Irm, Llc Compounds and compositions as protein kinase inhibitors
CA2608733A1 (fr) 2005-05-17 2007-02-01 Plexxikon, Inc. Composes modulant l'activite de c-kit et c-fms et utilisations
CN101263142A (zh) 2005-05-20 2008-09-10 阿雷生物药品公司 Raf抑制剂化合物及其使用方法
EP3088400A1 (fr) 2005-06-22 2016-11-02 Plexxikon Inc. Dérivés de pyrrolo[2,3-b]pyridine en tant qu'inhibiteurs de la protéine kinase
JP2009502843A (ja) 2005-07-29 2009-01-29 エフ．ホフマン−ラ ロシュ アーゲー アザベンズイミダゾール誘導体、それらの製造、及び抗癌剤としての使用
EP2099797B1 (fr) 2005-08-09 2010-09-29 Irm Llc Composes et compositions utiles comme inhibiteurs de proteines kinases
BRPI0615781A2 (pt) 2005-09-01 2009-06-16 Array Biopharma Inc compostos inibidores de raf e métodos de uso destes
EP1926737B1 (fr) 2005-09-15 2017-03-15 F. Hoffmann-La Roche AG Dérivés d'acide 4-amino-thiéno[3,2-c]pyridine-7-carboxylique
EP1951728A4 (fr) 2005-11-04 2011-04-20 Glaxosmithkline Llc Inhibiteurs de thienopyridine b-raf kinase
CA2632512A1 (fr) 2005-12-08 2007-06-14 Millennium Pharmaceuticals, Inc. Composes bicycliques ayant une activite inhibitrice de kinase
US20070191604A1 (en) 2005-12-13 2007-08-16 Alan Cooper Novel compounds that are ERK inhibitors
WO2007071963A2 (fr) 2005-12-22 2007-06-28 Astrazeneca Ab Composes chimiques
TW200804349A (en) 2005-12-23 2008-01-16 Kalypsys Inc Novel substituted pyrimidinyloxy ureas as inhibitors of protein kinases
WO2007076474A1 (fr) 2005-12-23 2007-07-05 Kalypsys, Inc. Nouveaux amides pyridinyloxy et pyrimidinyloxy substitués utilisés comme inhibiteurs de protéines kinases
WO2007076460A2 (fr) 2005-12-23 2007-07-05 Kalypsys, Inc. Nouveaux thiazole-urees substitues utiles en tant qu'inhibiteurs de proteine-kinases
WO2007113558A2 (fr) 2006-04-05 2007-10-11 Astrazeneca Ab Composés chimiques
EP2007736A1 (fr) 2006-04-05 2008-12-31 AstraZeneca AB Quinazolines substituées à activité anti-cancéreuse
WO2007119055A1 (fr) 2006-04-18 2007-10-25 Astrazeneca Ab Derives de quinazolin-4-one, procede de fabrication de ces derives et compositions pharmaceutiques les contenant
US20070224169A1 (en) * 2006-07-18 2007-09-27 Sliwa John W Jr Selectively switched gels for surgery, therapy and maintenance
KR101104666B1 (ko) 2006-09-06 2012-01-13 에프. 호프만-라 로슈 아게 단백질 키나제 억제제로서의 헤테로아릴 유도체
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US7897762B2 (en) 2006-09-14 2011-03-01 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of proliferative diseases
US8202876B2 (en) 2006-10-02 2012-06-19 Irm Llc Compounds and compositions as protein kinase inhibitors
WO2008044688A1 (fr) 2006-10-11 2008-04-17 Daiichi Sankyo Company, Limited Dérivé de l'urée
EP1914234A1 (fr) 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines et leur utilisation comme inhibiteurs de kinases
EP2094169A4 (fr) * 2006-12-11 2016-05-04 Pluromed Inc Hémostase d'organes perfusés
PE20121126A1 (es) 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (fr) 2006-12-21 2008-07-03 Plexxikon, Inc. Composés et méthodes de modulation des kinases, et indications connexes
MX2009006688A (es) 2006-12-21 2009-06-30 Plexxikon Inc Compuestos y metodos para modulacion de cinasas, e indicaciones para ello.
WO2008112695A2 (fr) 2007-03-12 2008-09-18 Irm Llc Inhibiteurs de protéine kinase et procédés d'utilisation de ceux-ci
WO2008124393A1 (fr) 2007-04-04 2008-10-16 Irm Llc Derives de benzothiazole et leur utilisation en tant qu'inhibiteurs des proteines kinases
WO2008144253A1 (fr) 2007-05-14 2008-11-27 Irm Llc Inhibiteurs de la protéine kinase et procédé d'utilisation de ceux-ci
MX2009013782A (es) 2007-06-15 2010-02-01 Irm Llc Inhibidores de cinasa de proteina y metodos para el uso de los mismos.
CN101687821A (zh) 2007-06-21 2010-03-31 Irm责任有限公司 蛋白激酶抑制剂及其使用方法
NZ582772A (en) 2007-07-17 2012-06-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
JP5270553B2 (ja) 2007-08-23 2013-08-21 武田薬品工業株式会社 複素環化合物およびその用途
JP5350247B2 (ja) 2007-08-29 2013-11-27 武田薬品工業株式会社 複素環化合物およびその用途
CL2009000447A1 (es) 2008-02-29 2010-01-04 Array Biopharma Inc Y Genentech Inc Compuestos derivados de (1h-pirrolo{2,3-b}piridin-5-il)-sulfonamido-benzamida sustituida; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer, a travez de la inhibicion de raf.
CA2716949A1 (fr) 2008-02-29 2009-09-11 Array Biopharma Inc. Derives de n-(6-aminopyridin-3-yl)-3-(sulfonamido) benzamide comme inhibiteurs de b-raf pour le traitement du cancer
JP2011513329A (ja) 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド ＲＡＦ阻害化合物として使用されるイミダゾ［４，５−ｂ］ピリジン誘導体
MY161576A (en) 2008-03-17 2017-04-28 Ambit Biosciences Corp Quinazoline derivatives as raf kinase modulators and methods of use thereof
GB0807609D0 (en) 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
US8158636B2 (en) 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
PE20091846A1 (es) 2008-05-19 2009-12-16 Plexxikon Inc DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
WO2009152087A1 (fr) 2008-06-10 2009-12-17 Plexxikon, Inc. Composés hétéroaryles bicycliques et procédés destinés à la modulation de kinases, et des indications pour celle-ci
EP2313411A1 (fr) 2008-06-10 2011-04-27 Plexxikon, Inc. Dérivés 5h-pyrrolo-[2,3-b]-pyrazine destinés à la modulation de kinases, et des indications pour ceux-ci
KR101061599B1 (ko) 2008-12-05 2011-09-02 한국과학기술연구원 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물

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CL2009000448A1 (es) 2009-11-27
TW200940539A (en) 2009-10-01
CR11690A (es) 2010-11-02
CA2716952A1 (fr) 2009-09-11
ECSP10010507A (es) 2010-10-30
CN102149712A (zh) 2011-08-10
KR20100117686A (ko) 2010-11-03
AR072657A1 (es) 2010-09-15
EP2265610A1 (fr) 2010-12-29
IL207845A0 (en) 2010-12-30
BRPI0908268A2 (pt) 2018-10-30
AU2009222144A1 (en) 2009-09-11
US8394795B2 (en) 2013-03-12
WO2009111279A1 (fr) 2009-09-11
ES2400202T3 (es) 2013-04-08
EP2265610B1 (fr) 2012-12-12
JP2011513331A (ja) 2011-04-28
MX2010009411A (es) 2010-11-30
PE20091623A1 (es) 2009-11-19

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