EA201590624A1 - Циклические эфиры пиразол-4-ил-гетероциклил-карбоксамидных соединений и способы их применения - Google Patents
Циклические эфиры пиразол-4-ил-гетероциклил-карбоксамидных соединений и способы их примененияInfo
- Publication number
- EA201590624A1 EA201590624A1 EA201590624A EA201590624A EA201590624A1 EA 201590624 A1 EA201590624 A1 EA 201590624A1 EA 201590624 A EA201590624 A EA 201590624A EA 201590624 A EA201590624 A EA 201590624A EA 201590624 A1 EA201590624 A1 EA 201590624A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrazol
- methods
- heterocyclil
- application
- cyclic ethers
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Abstract
Циклический эфир пиразол-4-ил-гетероциклил-карбоксамидных соединений формулы I, включая их стереоизомеры, геометрические изомеры, таутомеры и фармацевтически приемлемые соли, где Rпредставляет собой циклический эфир и X представляет собой тиазолил, пиразинил, пиридинил или пиримидинил, полезны для ингибирования Pirn киназы, и для лечения расстройств, таких как рак, опосредованных Pirn киназой. Раскрыты способы применения соединений формулы I для in vitro, in situ и in vivo диагностики, предотвращения или лечения таких заболеваний в клетках млекопитающих или ассоциированных патологических состояний.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201261705791P | 2012-09-26 | 2012-09-26 | |
US201361864882P | 2013-08-12 | 2013-08-12 | |
PCT/EP2013/069892 WO2014048939A1 (en) | 2012-09-26 | 2013-09-25 | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
Publications (2)
Publication Number | Publication Date |
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EA201590624A1 true EA201590624A1 (ru) | 2015-07-30 |
EA031622B1 EA031622B1 (ru) | 2019-01-31 |
Family
ID=49261521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA201590624A EA031622B1 (ru) | 2012-09-26 | 2013-09-25 | Содержащие циклическую эфирную группу пиразол-4-ил-гетероциклил-карбоксамидные соединения и способы их применения |
Country Status (28)
Country | Link |
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US (2) | US9328106B2 (ru) |
EP (1) | EP2900657B1 (ru) |
JP (2) | JP6666147B2 (ru) |
KR (1) | KR102281288B1 (ru) |
CN (1) | CN104640858B (ru) |
AU (2) | AU2013322736A1 (ru) |
BR (1) | BR112015006019B1 (ru) |
CA (1) | CA2881068C (ru) |
CL (1) | CL2015000530A1 (ru) |
CR (1) | CR20150119A (ru) |
DK (1) | DK2900657T3 (ru) |
EA (1) | EA031622B1 (ru) |
ES (1) | ES2791648T3 (ru) |
HK (1) | HK1206737A1 (ru) |
HR (1) | HRP20200681T1 (ru) |
HU (1) | HUE049611T2 (ru) |
IL (1) | IL237159A0 (ru) |
LT (1) | LT2900657T (ru) |
MX (1) | MX2015003513A (ru) |
PE (1) | PE20151375A1 (ru) |
PH (1) | PH12015500488B1 (ru) |
PL (1) | PL2900657T3 (ru) |
PT (1) | PT2900657T (ru) |
RS (1) | RS60202B1 (ru) |
SG (1) | SG11201502343RA (ru) |
SI (1) | SI2900657T1 (ru) |
UA (1) | UA119229C2 (ru) |
WO (1) | WO2014048939A1 (ru) |
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