BR112013020329A2 - compostos heterocíclicos como inibidores da pi3-quinase - Google Patents

compostos heterocíclicos como inibidores da pi3-quinase

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Publication number
BR112013020329A2
BR112013020329A2 BR112013020329A BR112013020329A BR112013020329A2 BR 112013020329 A2 BR112013020329 A2 BR 112013020329A2 BR 112013020329 A BR112013020329 A BR 112013020329A BR 112013020329 A BR112013020329 A BR 112013020329A BR 112013020329 A2 BR112013020329 A2 BR 112013020329A2
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BR
Brazil
Prior art keywords
compounds
kinase inhibitors
heterocyclic compounds
formula
treatment
Prior art date
Application number
BR112013020329A
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English (en)
Inventor
Bohdan Waszkowycz
Brian Safina
Daniel P Sutherlin
Eileen M Seward
Pascal Pierre Alexandre Savy
Robert Heald
Stephen Price
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112013020329A2 publication Critical patent/BR112013020329A2/pt

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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

compostos heterocíclicos como inibidores da pi3-quinase os compostos de fórmula i, incluindo os estereoisômeros, isômeros geométricos, tautômeros, metabólicos, e sais farmaceuticamente aceitáveis destes, são úteis para a inibição da isoforma delta pi3k, e para o tratamento de doenças mediadas por quinases de lipídeos, tais como inflamação, distúrbios imunológicos, e câncer. os métodos de utilização de compostos de fórmula i para diagnóstico, prevenção, ou tratamento in vitro, in situ e in vivo, dos respectivos distúrbios em células de mamíferos, ou condições patológicas associadas, são revelados.
BR112013020329A 2011-02-09 2012-02-08 compostos heterocíclicos como inibidores da pi3-quinase BR112013020329A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161441014P 2011-02-09 2011-02-09
PCT/EP2012/052090 WO2012107465A1 (en) 2011-02-09 2012-02-08 Heterocyclic compounds as pi3 kinase inhibitors

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BR112013020329A2 true BR112013020329A2 (pt) 2016-08-02

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US (1) US8653089B2 (pt)
EP (1) EP2673269A1 (pt)
JP (1) JP5766820B2 (pt)
KR (1) KR20130116358A (pt)
CN (1) CN103476767B (pt)
BR (1) BR112013020329A2 (pt)
CA (1) CA2825028A1 (pt)
MX (1) MX2013008822A (pt)
RU (1) RU2013138835A (pt)
WO (1) WO2012107465A1 (pt)

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