BR112016003019A2 - composto, composição farmacêutica, método para tratar câncer em um sujeito com necessidade do mesmo, e método para inibir uma desoxicitidina quinase - Google Patents
composto, composição farmacêutica, método para tratar câncer em um sujeito com necessidade do mesmo, e método para inibir uma desoxicitidina quinaseInfo
- Publication number
- BR112016003019A2 BR112016003019A2 BR112016003019A BR112016003019A BR112016003019A2 BR 112016003019 A2 BR112016003019 A2 BR 112016003019A2 BR 112016003019 A BR112016003019 A BR 112016003019A BR 112016003019 A BR112016003019 A BR 112016003019A BR 112016003019 A2 BR112016003019 A2 BR 112016003019A2
- Authority
- BR
- Brazil
- Prior art keywords
- treating cancer
- inhibiting
- subject
- need
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
resumo composto, composição farmacêutica, método para tratar câncer em um sujeito com necessidade do mesmo, e método para inibir uma desoxicitidina quinase são fornecidos aqui compostos que se ligam a dck e métodos para tratar câncer. 1/1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361865468P | 2013-08-13 | 2013-08-13 | |
PCT/US2014/050931 WO2015023776A2 (en) | 2013-08-13 | 2014-08-13 | Deoxycytidine kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016003019A2 true BR112016003019A2 (pt) | 2017-09-12 |
Family
ID=52468801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016003019A BR112016003019A2 (pt) | 2013-08-13 | 2014-08-13 | composto, composição farmacêutica, método para tratar câncer em um sujeito com necessidade do mesmo, e método para inibir uma desoxicitidina quinase |
Country Status (11)
Country | Link |
---|---|
US (2) | US9598404B2 (pt) |
EP (1) | EP3033340B1 (pt) |
JP (1) | JP6542216B2 (pt) |
KR (1) | KR102330566B1 (pt) |
CN (1) | CN105658648B (pt) |
AU (1) | AU2014306673B2 (pt) |
BR (1) | BR112016003019A2 (pt) |
CA (1) | CA2920738A1 (pt) |
EA (1) | EA036177B1 (pt) |
IL (1) | IL244029B (pt) |
WO (1) | WO2015023776A2 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102330566B1 (ko) * | 2013-08-13 | 2021-11-25 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 데옥시시티딘 키나제 저해제들 |
CN108779111B (zh) * | 2016-01-08 | 2021-11-12 | 加利福尼亚大学董事会 | 结合脱氧胞苷激酶的化合物 |
CN106421790B (zh) * | 2016-11-25 | 2018-12-25 | 复旦大学附属金山医院 | Cmpk的抑制剂在制备治疗卵巢癌的药物中的应用 |
CN109134354B (zh) * | 2018-09-19 | 2022-03-25 | 天津科技大学 | 2-吡啶甲基硫醚的合成方法及相关药物的合成工艺 |
US20220133735A1 (en) | 2020-11-02 | 2022-05-05 | Trethera Corporation | Crystalline forms of a deoxycytidine kinase inhibitor and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080014657A1 (en) | 2006-07-12 | 2008-01-17 | Beckton Dickinson And Company | Use of Albumin, Bovine, P-Aminophenyl N-Acetyl B-D Glucosaminide as a Control Line for an Immunoassay Device |
US8093246B2 (en) * | 2006-12-14 | 2012-01-10 | Lexicon Pharmaceuticals, Inc. | O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer |
EP2445898A2 (en) * | 2009-06-25 | 2012-05-02 | Amgen, Inc | 4h-pyrido[1,2-a]pyrimidin-4-one derivatives as pi3k inhibitors |
WO2012107465A1 (en) * | 2011-02-09 | 2012-08-16 | F. Hoffmann-La Roche Ag | Heterocyclic compounds as pi3 kinase inhibitors |
WO2012122368A1 (en) * | 2011-03-08 | 2012-09-13 | The Regents Of The University Of California | Deoxycytidine kinase binding compounds |
EP2518071A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Imidazopyridine derivatives as PI3K inhibitors |
EP2518070A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
US20130123281A1 (en) * | 2011-11-11 | 2013-05-16 | Beta Cat Pharmaceuticals, Llc | Compositions and Methods for Inhibition of TBL-1 Binding to Disease-Associated Molecules |
KR102330566B1 (ko) * | 2013-08-13 | 2021-11-25 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 데옥시시티딘 키나제 저해제들 |
-
2014
- 2014-08-13 KR KR1020167006675A patent/KR102330566B1/ko active IP Right Grant
- 2014-08-13 JP JP2016534818A patent/JP6542216B2/ja active Active
- 2014-08-13 BR BR112016003019A patent/BR112016003019A2/pt not_active Application Discontinuation
- 2014-08-13 CN CN201480055864.1A patent/CN105658648B/zh active Active
- 2014-08-13 EA EA201690376A patent/EA036177B1/ru not_active IP Right Cessation
- 2014-08-13 CA CA2920738A patent/CA2920738A1/en not_active Abandoned
- 2014-08-13 WO PCT/US2014/050931 patent/WO2015023776A2/en active Application Filing
- 2014-08-13 EP EP14836561.2A patent/EP3033340B1/en active Active
- 2014-08-13 AU AU2014306673A patent/AU2014306673B2/en active Active
-
2016
- 2016-01-11 US US14/992,396 patent/US9598404B2/en active Active
- 2016-02-08 IL IL24402916A patent/IL244029B/en active IP Right Grant
-
2017
- 2017-01-31 US US15/421,258 patent/US9981961B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EA201690376A1 (ru) | 2016-07-29 |
EA036177B1 (ru) | 2020-10-09 |
US9598404B2 (en) | 2017-03-21 |
CN105658648A (zh) | 2016-06-08 |
CN105658648B (zh) | 2020-03-17 |
AU2014306673B2 (en) | 2018-12-06 |
JP6542216B2 (ja) | 2019-07-10 |
WO2015023776A3 (en) | 2015-11-12 |
EP3033340A2 (en) | 2016-06-22 |
EP3033340A4 (en) | 2017-01-25 |
EP3033340B1 (en) | 2019-12-04 |
US20170204090A1 (en) | 2017-07-20 |
US20160237076A1 (en) | 2016-08-18 |
IL244029B (en) | 2019-10-31 |
WO2015023776A2 (en) | 2015-02-19 |
US9981961B2 (en) | 2018-05-29 |
CA2920738A1 (en) | 2015-02-19 |
KR20160058785A (ko) | 2016-05-25 |
AU2014306673A1 (en) | 2016-03-03 |
IL244029A0 (en) | 2016-04-21 |
KR102330566B1 (ko) | 2021-11-25 |
JP2016530266A (ja) | 2016-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12019501393A1 (en) | Afucosylated anti-fgfr2iiib antibodies | |
BR112017020054A2 (pt) | anticorpos para icos | |
HK1215378A1 (zh) | 藥物組合物、治療方法及其用途 | |
CL2015002932A1 (es) | Inhibidores de proteína quinasa | |
BR112017023821A2 (pt) | moduladores de k-ras | |
PH12016500739A1 (en) | Inhibitors of the fibrolast growth factor receptor | |
BR112015032718A2 (pt) | composto de modificação de splicing do gene foxm1, uso do composto, formulação farmacêutica e métodos de triagem de compostos | |
BR112018012914A2 (pt) | composto, método para tratar, prevenir ou melhorar um ou mais sintomas de câncer, método para tratar, prevenir ou melhorar um ou mais sintomas de uma doença inflamatória e composição farmacêutica | |
CL2011000454A1 (es) | Compuestos derivados de picolinamida, inhibidores de quinasa pim, asociada a tumorigenesis; composicion farmaceutica que los comprende; y su uso en el tratamiento del cancer. | |
EA201300810A1 (ru) | Противораковая терапия с использованием двойных ингибиторов киназ аврора/мек | |
MX2019008065A (es) | Composiciones que comprenden anticuerpos anti-cd38 y lenalidomida. | |
EA201591137A1 (ru) | Ингибиторы mk2 и их применения | |
BR112018006696A2 (pt) | métodos e sistemas para obter óleo a partir de uma composição de vinhoto | |
BR112018006140A2 (pt) | anticorpo ou uma porção de ligação a antígeno do mesmo, composição farmacêutica, e, método para inibição de proliferação de células cancerígenas. | |
BR112016003019A2 (pt) | composto, composição farmacêutica, método para tratar câncer em um sujeito com necessidade do mesmo, e método para inibir uma desoxicitidina quinase | |
MY175418A (en) | Compositions comprising anti-cd38 antibodies and carfilzomib | |
BR112018011027A2 (pt) | técnicas para alocação de casos | |
IL241823B (en) | Preparations containing novyi .c and their uses for the treatment of cancerous tumors | |
IL267159B (en) | A pharmaceutical preparation containing e7386 given in combination with lanuatinib for the treatment of tumors | |
BR112017009265A2 (pt) | apilimode para uso no tratamento do câncer colorretal | |
BR112015023383A2 (pt) | compostocomposição farmacêutica; e método de modulação | |
BR112017024163A2 (pt) | compostos bicíclicos | |
EP3365336A4 (en) | Deuterated compounds for treating hematologic malignancies, and compositions and methods thereof | |
EP3020399A4 (en) | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF CANCER | |
IL269769B (en) | Mixtures, composition and their use for cancer treatment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 417/12 , C07D 417/14 , G01N 33/50 Ipc: C07D 417/12 (2006.01), C07D 417/14 (2006.01), ... |
|
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |