MX2016007171A - Compuestos de heteroaril piridona y azapiridona con funcionalidad electrofila. - Google Patents
Compuestos de heteroaril piridona y azapiridona con funcionalidad electrofila.Info
- Publication number
- MX2016007171A MX2016007171A MX2016007171A MX2016007171A MX2016007171A MX 2016007171 A MX2016007171 A MX 2016007171A MX 2016007171 A MX2016007171 A MX 2016007171A MX 2016007171 A MX2016007171 A MX 2016007171A MX 2016007171 A MX2016007171 A MX 2016007171A
- Authority
- MX
- Mexico
- Prior art keywords
- pyridone
- aza
- compounds
- heteroaryl
- electrophilic functionality
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Se proporcionan compuestos de heteroaril piridona y azapiridona amida con funcionalidad electrófila de Fórmula I, incluyendo estereoisómeros, tautómeros, y sales farmacéuticamente aceptables de los mismos, útiles para inhibir Btk, y para tratar cáncer y trastornos inmunes tales como inflamación mediada por Btk. Se desvelan métodos de uso de los compuestos de Fórmula I para diagnóstico in vitro, in situ, e in vivo, y el tratamiento de tales trastornos en células de mamífero, o afecciones patológicas asociadas. (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361912147P | 2013-12-05 | 2013-12-05 | |
PCT/EP2014/076498 WO2015082583A1 (en) | 2013-12-05 | 2014-12-04 | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016007171A true MX2016007171A (es) | 2016-09-08 |
Family
ID=52011205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016007171A MX2016007171A (es) | 2013-12-05 | 2014-12-04 | Compuestos de heteroaril piridona y azapiridona con funcionalidad electrofila. |
Country Status (10)
Country | Link |
---|---|
US (1) | US9260415B2 (es) |
EP (1) | EP3077384B1 (es) |
JP (1) | JP6275846B2 (es) |
KR (1) | KR101813830B1 (es) |
CN (1) | CN105793251B (es) |
CA (1) | CA2929918C (es) |
HK (1) | HK1222858A1 (es) |
MX (1) | MX2016007171A (es) |
RU (1) | RU2646758C2 (es) |
WO (1) | WO2015082583A1 (es) |
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UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
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AR102871A1 (es) | 2014-12-03 | 2017-03-29 | Pharmacyclics Llc | Métodos de tratamiento de fibrosis |
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EP3930717A1 (en) * | 2019-02-25 | 2022-01-05 | Guangzhou Lupeng Pharmaceutical Company Ltd. | Inhibitor of btk and mutants thereof |
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CA3171012A1 (en) * | 2020-02-20 | 2021-08-26 | Hutchison Medipharma Limited | Heteroaryl heterocyclic compounds and uses thereof |
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-
2014
- 2014-12-04 JP JP2016535205A patent/JP6275846B2/ja active Active
- 2014-12-04 KR KR1020167017129A patent/KR101813830B1/ko active IP Right Grant
- 2014-12-04 US US14/560,087 patent/US9260415B2/en active Active
- 2014-12-04 CA CA2929918A patent/CA2929918C/en not_active Expired - Fee Related
- 2014-12-04 RU RU2016124269A patent/RU2646758C2/ru active
- 2014-12-04 MX MX2016007171A patent/MX2016007171A/es unknown
- 2014-12-04 CN CN201480066559.2A patent/CN105793251B/zh active Active
- 2014-12-04 EP EP14808596.2A patent/EP3077384B1/en active Active
- 2014-12-04 WO PCT/EP2014/076498 patent/WO2015082583A1/en active Application Filing
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2016
- 2016-09-22 HK HK16111114.0A patent/HK1222858A1/zh unknown
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Publication number | Publication date |
---|---|
JP2017502933A (ja) | 2017-01-26 |
KR20160090890A (ko) | 2016-08-01 |
CA2929918A1 (en) | 2015-06-11 |
US20150158846A1 (en) | 2015-06-11 |
US9260415B2 (en) | 2016-02-16 |
RU2646758C2 (ru) | 2018-03-07 |
JP6275846B2 (ja) | 2018-02-07 |
CA2929918C (en) | 2018-01-23 |
WO2015082583A1 (en) | 2015-06-11 |
CN105793251A (zh) | 2016-07-20 |
EP3077384B1 (en) | 2017-09-06 |
EP3077384A1 (en) | 2016-10-12 |
CN105793251B (zh) | 2018-10-12 |
KR101813830B1 (ko) | 2017-12-29 |
HK1222858A1 (zh) | 2017-07-14 |
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