WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
JP2010533729A
(ja)
|
2007-07-17 |
2010-10-28 |
プレキシコン,インコーポレーテッド |
キナーゼ調節のための化合物と方法、及びそのための適応
|
CA2716947A1
(en)
*
|
2008-02-29 |
2009-09-11 |
Array Biopharma Inc. |
Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
|
AR070535A1
(es)
*
|
2008-02-29 |
2010-04-14 |
Array Biopharma Inc |
Compuestos inhibidores de raf y metodos para usarlos
|
PE20091623A1
(es)
*
|
2008-02-29 |
2009-11-19 |
Array Biopharma Inc |
DERIVADOS DE 1H-PIRAZOLO[3,4-b]PIRIDINA COMO INHIBIDORES DE RAF QUINASA
|
WO2009111280A1
(en)
*
|
2008-02-29 |
2009-09-11 |
Array Biopharma Inc. |
N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
|
WO2009143018A2
(en)
|
2008-05-19 |
2009-11-26 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
CN101801015B
(zh)
*
|
2009-02-06 |
2014-03-12 |
中兴通讯股份有限公司 |
一种小区退服故障的处理方法及装置
|
NZ595890A
(en)
|
2009-03-26 |
2013-09-27 |
Takeda Pharmaceutical |
Pyrazole compound
|
PE20120876A1
(es)
|
2009-04-03 |
2012-08-05 |
Hoffmann La Roche |
Composiciones del acido propano-1-sulfonico{3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil}-amida
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
PE20121327A1
(es)
|
2009-11-06 |
2012-10-18 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello
|
RU2012125070A
(ru)
|
2009-11-18 |
2013-12-27 |
Плексксикон, Инк. |
Соединения и способы модулирования киназы и показания к их применению
|
KR20120112623A
(ko)
|
2009-12-23 |
2012-10-11 |
플렉시콘, 인코퍼레이티드 |
키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
|
EP2519525A4
(en)
*
|
2009-12-30 |
2013-06-12 |
Arqule Inc |
SUBSTITUTED PYRROLO-AMINOPYRIMIDINE COMPOUNDS
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
US8771687B2
(en)
|
2010-12-02 |
2014-07-08 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Methods for treating a tumor using an antibody that specifically binds GRP94
|
PL2672967T3
(pl)
|
2011-02-07 |
2019-04-30 |
Plexxikon Inc |
Związki i sposoby modulacji kinaz i wskazania ku temu
|
KR101298651B1
(ko)
*
|
2011-03-16 |
2013-08-21 |
연세대학교 산학협력단 |
효능이 강화된 혈관신생 억제용 약제학적 조성물
|
GEP20156417B
(en)
|
2011-04-05 |
2015-12-25 |
Pfizer Ltd |
Pyrrolo [2,3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases
|
JP6113151B2
(ja)
|
2011-05-17 |
2017-04-12 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼ調節およびその適応症
|
ES2548414T3
(es)
|
2011-07-08 |
2015-10-16 |
Novartis Ag |
Novedosos derivados de pirrolo pirimidina
|
US9358235B2
(en)
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
KR20180088926A
(ko)
|
2012-07-24 |
2018-08-07 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
|
US10227357B2
(en)
|
2012-09-06 |
2019-03-12 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
CA2885259A1
(en)
|
2012-10-04 |
2014-04-10 |
Pfizer Limited |
Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
|
US20150250785A1
(en)
|
2012-10-04 |
2015-09-10 |
Pfizer Limited |
Tropomyosin-Related Kinase Inhibitors
|
CA2885253A1
(en)
|
2012-10-04 |
2014-04-10 |
Pfizer Limited |
Pyrrolo[2,3-d]pyrimidine tropomyosin-related kinase inhibitors
|
EP2935248B1
(en)
|
2012-12-21 |
2018-02-28 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
US20140303121A1
(en)
|
2013-03-15 |
2014-10-09 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
SG11201506687RA
(en)
|
2013-03-15 |
2015-09-29 |
Plexxikon Inc |
Heterocyclic compounds and uses thereof
|
MX2015015966A
(es)
|
2013-05-30 |
2016-04-13 |
Plexxikon Inc |
Compuestos para la modulacion de cinasas e indicaciones para los mismos.
|
JP2016540811A
(ja)
|
2013-12-20 |
2016-12-28 |
ファイザー・リミテッドPfizer Limited |
N−アシルピペリジンエーテルトロポミオシン関連キナーゼ阻害剤
|
US9771369B2
(en)
|
2014-03-04 |
2017-09-26 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
US20170197939A1
(en)
|
2014-04-15 |
2017-07-13 |
Pfizer Inc. |
Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety
|
EP3140298A1
(en)
|
2014-05-07 |
2017-03-15 |
Pfizer Inc. |
Tropomyosin-related kinase inhibitors
|
WO2016009296A1
(en)
|
2014-07-16 |
2016-01-21 |
Pfizer Inc. |
N-acylpiperidine ether tropomyosin-related kinase inhibitors
|
WO2016020784A1
(en)
|
2014-08-05 |
2016-02-11 |
Pfizer Inc. |
N-acylpyrrolidine ether tropomyosin-related kinase inhibitors
|
AU2015318233B2
(en)
|
2014-09-15 |
2020-03-12 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
EP3204516B1
(en)
|
2014-10-06 |
2023-04-26 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
US10160755B2
(en)
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
EP3292122B1
(en)
|
2015-05-06 |
2020-01-15 |
Plexxikon Inc. |
Synthesis of 1h-pyrrolo[2,3-b]pyridin derivatives that modulate kinases
|
JP6946194B2
(ja)
|
2015-05-06 |
2021-10-06 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼを調節する化合物の固体形態
|
US10421756B2
(en)
|
2015-07-06 |
2019-09-24 |
Rodin Therapeutics, Inc. |
Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
|
JP6936796B2
(ja)
|
2015-07-06 |
2021-09-22 |
ロダン・セラピューティクス,インコーポレーテッド |
ヒストンデアセチラーゼのヘテロハロ阻害剤
|
TN2018000027A1
(en)
|
2015-07-16 |
2019-07-08 |
Array Biopharma Inc |
Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
|
US10829484B2
(en)
|
2015-07-28 |
2020-11-10 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
JP6863970B2
(ja)
|
2015-09-21 |
2021-04-21 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
ヘテロ環式化合物およびそれらの使用
|
BR112018008357A2
(pt)
|
2015-10-26 |
2018-11-27 |
Array Biopharma Inc |
mutações de ponto em câncer resistente a inibidor de trk e métodos relacionados às mesmas
|
JP6862468B2
(ja)
|
2015-12-07 |
2021-04-21 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼ調節のための化合物及び方法ならびにそのための指示
|
US9630968B1
(en)
|
2015-12-23 |
2017-04-25 |
Arqule, Inc. |
Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
|
WO2017133669A1
(en)
*
|
2016-02-05 |
2017-08-10 |
Savira Pharmaceuticals Gmbh |
5, 7-diazaindole and 5, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza
|
AU2017232610B2
(en)
|
2016-03-16 |
2021-07-22 |
Plexxikon Inc. |
Compounds and methods for kinase modulation and indications therefore
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
KR20180129911A
(ko)
|
2016-04-04 |
2018-12-05 |
록쏘 온콜로지, 인코포레이티드 |
소아암을 치료하는 방법
|
CR20180501A
(es)
|
2016-04-04 |
2019-04-05 |
Loxo Oncology Inc |
Formulaciones liquidas de (s)-n-(5-((r)-2(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a] pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
|
PT3800189T
(pt)
|
2016-05-18 |
2023-07-27 |
Array Biopharma Inc |
Preparação de (s)-n-(5-((r)-2-(2,5- difluoropenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3- il)-3-hidroxipirrolidina-1-carboxamida
|
WO2018004306A1
(en)
*
|
2016-06-30 |
2018-01-04 |
Daewoong Pharmaceutical Co., Ltd. |
Pyrazolopyrimidine derivatives as kinase inhibitor
|
CN107722013B
(zh)
*
|
2016-08-11 |
2021-01-12 |
中国科学院上海药物研究所 |
去氮嘌呤类化合物及其药物组合物、制备方法和用途
|
KR20190035925A
(ko)
|
2016-08-24 |
2019-04-03 |
아르퀼 인코포레이티드 |
아미노-피롤로피리미디논 화합물 및 이의 사용 방법
|
TW201815766A
(zh)
|
2016-09-22 |
2018-05-01 |
美商普雷辛肯公司 |
用於ido及tdo調節之化合物及方法以及其適應症
|
JOP20190077A1
(ar)
|
2016-10-10 |
2019-04-09 |
Array Biopharma Inc |
مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
|
TWI704148B
(zh)
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
CA3047580A1
(en)
|
2016-12-23 |
2018-07-26 |
Plexxikon Inc. |
Compounds and methods for cdk8 modulation and indications therefor
|
ES2909086T3
(es)
|
2017-01-11 |
2022-05-05 |
Alkermes Inc |
Inhibidores bicíclicos de histona desacetilasa
|
WO2018136663A1
(en)
|
2017-01-18 |
2018-07-26 |
Array Biopharma, Inc. |
Ret inhibitors
|
CN110267960B
(zh)
|
2017-01-18 |
2022-04-26 |
阿雷生物药品公司 |
作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
|
WO2018160824A1
(en)
|
2017-03-01 |
2018-09-07 |
Prelude Therapeutics, Incorporated |
Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
AU2018237047A1
(en)
|
2017-03-20 |
2019-10-17 |
Plexxikon Inc. |
Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain
|
US10428067B2
(en)
|
2017-06-07 |
2019-10-01 |
Plexxikon Inc. |
Compounds and methods for kinase modulation
|
EP3658189A1
(en)
|
2017-07-25 |
2020-06-03 |
Plexxikon Inc. |
Formulations of a compound modulating kinases
|
MA49839B1
(fr)
|
2017-08-07 |
2022-05-31 |
Alkermes Inc |
Inhibiteurs bicycliques de la histone déacétylase
|
TWI812649B
(zh)
|
2017-10-10 |
2023-08-21 |
美商絡速藥業公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
|
TWI791053B
(zh)
|
2017-10-10 |
2023-02-01 |
美商亞雷生物製藥股份有限公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
|
AU2018348241B2
(en)
|
2017-10-13 |
2023-01-12 |
Opna Bio SA |
Solid forms of a compound for modulating kinases
|
BR112020007972A2
(pt)
|
2017-10-27 |
2020-10-20 |
Plexxikon, Inc. |
formulações de composto que modula quinases
|
CN111615514B
(zh)
|
2018-01-18 |
2022-10-11 |
奥瑞生物药品公司 |
作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物
|
WO2019143977A1
(en)
|
2018-01-18 |
2019-07-25 |
Array Biopharma Inc. |
Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
|
TW201938169A
(zh)
|
2018-01-18 |
2019-10-01 |
美商亞雷生物製藥股份有限公司 |
作為RET激酶抑制劑之經取代吡唑并[3,4-d]嘧啶化合物
|
WO2019183145A1
(en)
|
2018-03-20 |
2019-09-26 |
Plexxikon Inc. |
Compounds and methods for ido and tdo modulation, and indications therefor
|
JP7286755B2
(ja)
|
2018-07-31 |
2023-06-05 |
ロクソ オンコロジー, インコーポレイテッド |
(s)-5-アミノ-3-(4-((5-フルオロ-2-メトキシベンズアミド)メチル)フェニル)-1-(1,1,1-トリフルオロプロパン-2-イル)-1h-ピラゾール-4-カルボキサミドの噴霧乾燥分散体および製剤
|
ES2922314T3
(es)
|
2018-09-10 |
2022-09-13 |
Array Biopharma Inc |
Compuestos heterocíclicos condensados como inhibidores de cinasa RET
|
CN113490666A
(zh)
|
2018-12-19 |
2021-10-08 |
奥瑞生物药品公司 |
作为fgfr酪氨酸激酶的抑制剂的取代的吡唑并[1,5-a]吡啶化合物
|
WO2020131674A1
(en)
|
2018-12-19 |
2020-06-25 |
Array Biopharma Inc. |
7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
|
WO2020210366A1
(en)
|
2019-04-09 |
2020-10-15 |
Plexxikon Inc. |
Condensed azines for ep300 or cbp modulation and indications therefor
|
CN110618271B
(zh)
*
|
2019-09-29 |
2023-06-13 |
中国医学科学院肿瘤医院 |
非小细胞肺癌的预后预测方法
|
US20240018157A1
(en)
|
2019-12-27 |
2024-01-18 |
Schrödinger, Inc. |
Cyclic compounds and methods of using same
|
CN116323588A
(zh)
|
2020-04-23 |
2023-06-23 |
奥普纳生物有限公司 |
用于cd73调节的化合物和方法及其适应症
|
JP2023542473A
(ja)
|
2020-08-21 |
2023-10-10 |
プレキシコン インコーポレーテッド |
併用薬抗がん治療
|
WO2022055963A1
(en)
|
2020-09-10 |
2022-03-17 |
Schrödinger, Inc. |
Heterocyclic pericondensed cdc7 kinase inhibitors for the treatment of cancer
|
WO2022164789A1
(en)
|
2021-01-26 |
2022-08-04 |
Schrödinger, Inc. |
Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disoders
|
TW202300150A
(zh)
|
2021-03-18 |
2023-01-01 |
美商薛定諤公司 |
環狀化合物及其使用方法
|
CN114409654A
(zh)
*
|
2021-12-30 |
2022-04-29 |
安徽普利药业有限公司 |
一种btk抑制剂的中间体合成方法
|