EA201171385A1 - Производные циклопента[с]пирролилалкилкарбаматов 5-членных гетероциклов, способ их получения и применение их в терапии - Google Patents
Производные циклопента[с]пирролилалкилкарбаматов 5-членных гетероциклов, способ их получения и применение их в терапииInfo
- Publication number
- EA201171385A1 EA201171385A1 EA201171385A EA201171385A EA201171385A1 EA 201171385 A1 EA201171385 A1 EA 201171385A1 EA 201171385 A EA201171385 A EA 201171385A EA 201171385 A EA201171385 A EA 201171385A EA 201171385 A1 EA201171385 A1 EA 201171385A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- therapy
- pyrrolylalkylcarbamates
- cyclopent
- derivatives
- production
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Pain & Pain Management (AREA)
- Cardiology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Pulmonology (AREA)
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Abstract
Соединения общей формулы (I), в которой Rозначает атом водорода, фтора или гидроксильную, циано, трифторметильную, C-алкильную, C-алкоксигруппу; NRR; m и p означают 1; n и о имеют одно и то же значение и означают 0 или 1; А означает ковалентную связь или C-алкиленовувэ группу; Rозначает арильную или гетероарильную группу, необязательно замещенную; Rозначает атом водорода, фтора, C-алкильную или трифторметильную группу; Rозначает 5-членный гетероцикл, необязательно замещенный; в форме основания или кислотно-аддитивной соли. Применяются в терапии.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0902267A FR2945533B1 (fr) | 2009-05-12 | 2009-05-12 | Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
PCT/FR2010/050912 WO2010130943A1 (fr) | 2009-05-12 | 2010-05-11 | Dérivés de cyclopenta[c]pyrrolylalkylcarbamates d'hétérocycles à 5 chaînons, leur préparation et leur application en thérapeutique |
Publications (1)
Publication Number | Publication Date |
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EA201171385A1 true EA201171385A1 (ru) | 2012-05-30 |
Family
ID=41259809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171385A EA201171385A1 (ru) | 2009-05-12 | 2010-05-11 | Производные циклопента[с]пирролилалкилкарбаматов 5-членных гетероциклов, способ их получения и применение их в терапии |
Country Status (20)
Country | Link |
---|---|
US (1) | US8865738B2 (ru) |
EP (1) | EP2429998B1 (ru) |
JP (1) | JP5812985B2 (ru) |
KR (1) | KR20120014202A (ru) |
CN (1) | CN102459189B (ru) |
AR (1) | AR076561A1 (ru) |
AU (1) | AU2010247212B2 (ru) |
BR (1) | BRPI1014269A2 (ru) |
CA (1) | CA2761658C (ru) |
CO (1) | CO6460742A2 (ru) |
EA (1) | EA201171385A1 (ru) |
FR (1) | FR2945533B1 (ru) |
IL (1) | IL216228A0 (ru) |
MA (1) | MA33352B1 (ru) |
MX (1) | MX2011012057A (ru) |
SG (1) | SG176014A1 (ru) |
TN (1) | TN2011000550A1 (ru) |
TW (1) | TW201100413A (ru) |
UY (1) | UY32632A (ru) |
WO (1) | WO2010130943A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130150346A1 (en) | 2010-01-08 | 2013-06-13 | Quest Ventures Ltd. | Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome |
WO2011123719A2 (en) | 2010-03-31 | 2011-10-06 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating abdominal, visceral and pelvic pain |
RU2015111206A (ru) * | 2012-08-30 | 2016-10-20 | Ниппон Синяку Ко., Лтд. | Пиридиновое производное и лекарственное средство |
ITMI20131180A1 (it) * | 2013-07-15 | 2015-01-16 | Fond Istituto Italiano Di Tecnologia | O-alchil triazolil carbammati come inibitori di idrolasi delle ammidi degli acidi grassi (faah) |
ES2910848T3 (es) | 2013-09-26 | 2022-05-13 | Cadent Therapeutics Inc | Moduladores negativos de octahidro-ciclopenta[c]pirrol selectivos de NR2B |
JO3579B1 (ar) | 2014-09-26 | 2020-07-05 | Luc Therapeutics Inc | مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول |
CN111201223B (zh) * | 2017-09-11 | 2024-07-09 | 克鲁松制药公司 | SHP2的八氢环戊二烯并[c]吡咯别构抑制剂 |
WO2019057123A1 (zh) * | 2017-09-20 | 2019-03-28 | 杭州英创医药科技有限公司 | 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物 |
US20210395222A1 (en) * | 2018-10-05 | 2021-12-23 | New York University | Fused Bicyclic Heterocycles as Therapeutic Agents |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2816938B1 (fr) | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
US7247628B2 (en) * | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
FR2864080B1 (fr) * | 2003-12-23 | 2006-02-03 | Sanofi Synthelabo | Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique |
FR2866884B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique |
FR2866888B1 (fr) * | 2004-02-26 | 2006-05-05 | Sanofi Synthelabo | Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique |
WO2006108059A1 (en) | 2005-04-06 | 2006-10-12 | Exelixis, Inc. | C-met modulators and methods of use |
GB0510204D0 (en) * | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
EP1931633A2 (en) * | 2005-09-05 | 2008-06-18 | Ranbaxy Laboratories Limited | Derivatives of 3-azabicyclo[3.1.0]hexane as dipeptidyl peptidase-iv inhibitors |
NL2000323C2 (nl) * | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
AU2007277253A1 (en) | 2006-07-24 | 2008-01-31 | Gilead Sciences, Inc. | Bisfuranyl protease inhibitors |
WO2008031556A2 (en) * | 2006-09-12 | 2008-03-20 | Ucb Pharma, S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
CL2008001002A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
WO2009090548A2 (en) * | 2008-01-17 | 2009-07-23 | Glenmark Pharmaceuticals, S.A. | 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands |
FR2934265B1 (fr) * | 2008-07-23 | 2010-07-30 | Sanofi Aventis | Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique |
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2009
- 2009-05-12 FR FR0902267A patent/FR2945533B1/fr active Active
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2010
- 2010-05-11 AR ARP100101599A patent/AR076561A1/es not_active Application Discontinuation
- 2010-05-11 JP JP2012510340A patent/JP5812985B2/ja not_active Expired - Fee Related
- 2010-05-11 CN CN201080030952.8A patent/CN102459189B/zh not_active Expired - Fee Related
- 2010-05-11 WO PCT/FR2010/050912 patent/WO2010130943A1/fr active Application Filing
- 2010-05-11 US US13/319,635 patent/US8865738B2/en not_active Expired - Fee Related
- 2010-05-11 MA MA34436A patent/MA33352B1/fr unknown
- 2010-05-11 CA CA2761658A patent/CA2761658C/fr not_active Expired - Fee Related
- 2010-05-11 SG SG2011083144A patent/SG176014A1/en unknown
- 2010-05-11 EP EP10728740.1A patent/EP2429998B1/fr active Active
- 2010-05-11 KR KR1020117029576A patent/KR20120014202A/ko not_active Application Discontinuation
- 2010-05-11 EA EA201171385A patent/EA201171385A1/ru unknown
- 2010-05-11 MX MX2011012057A patent/MX2011012057A/es active IP Right Grant
- 2010-05-11 TW TW099115020A patent/TW201100413A/zh unknown
- 2010-05-11 AU AU2010247212A patent/AU2010247212B2/en not_active Ceased
- 2010-05-11 BR BRPI1014269A patent/BRPI1014269A2/pt not_active IP Right Cessation
- 2010-05-12 UY UY0001032632A patent/UY32632A/es not_active Application Discontinuation
-
2011
- 2011-10-31 TN TNP2011000550A patent/TN2011000550A1/fr unknown
- 2011-11-08 IL IL216228A patent/IL216228A0/en unknown
- 2011-11-11 CO CO11153614A patent/CO6460742A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FR2945533B1 (fr) | 2011-05-27 |
AU2010247212B2 (en) | 2015-07-16 |
CA2761658A1 (fr) | 2010-11-18 |
TN2011000550A1 (fr) | 2013-05-24 |
CN102459189B (zh) | 2014-11-05 |
FR2945533A1 (fr) | 2010-11-19 |
JP5812985B2 (ja) | 2015-11-17 |
IL216228A0 (en) | 2012-01-31 |
TW201100413A (en) | 2011-01-01 |
AU2010247212A1 (en) | 2011-12-08 |
AR076561A1 (es) | 2011-06-22 |
MA33352B1 (fr) | 2012-06-01 |
BRPI1014269A2 (pt) | 2016-04-05 |
CA2761658C (fr) | 2017-04-11 |
EP2429998B1 (fr) | 2013-11-27 |
MX2011012057A (es) | 2012-02-28 |
KR20120014202A (ko) | 2012-02-16 |
US8865738B2 (en) | 2014-10-21 |
US20120136026A1 (en) | 2012-05-31 |
EP2429998A1 (fr) | 2012-03-21 |
WO2010130943A1 (fr) | 2010-11-18 |
CO6460742A2 (es) | 2012-06-15 |
CN102459189A (zh) | 2012-05-16 |
JP2012526782A (ja) | 2012-11-01 |
UY32632A (es) | 2010-12-31 |
SG176014A1 (en) | 2011-12-29 |
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