EA201170099A1 - Замещенные пиримидин-4-оновые производные - Google Patents

Замещенные пиримидин-4-оновые производные

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Publication number
EA201170099A1
EA201170099A1 EA201170099A EA201170099A EA201170099A1 EA 201170099 A1 EA201170099 A1 EA 201170099A1 EA 201170099 A EA201170099 A EA 201170099A EA 201170099 A EA201170099 A EA 201170099A EA 201170099 A1 EA201170099 A1 EA 201170099A1
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EA
Eurasian Patent Office
Prior art keywords
group
alkyl group
phenyl
halogen atom
atom
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EA201170099A
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English (en)
Inventor
Од Фэйоль
Алистер Локхед
Мурад Саади
Жюльен Ваш
Филипп Иэш
Original Assignee
Мицубиси Танабе Фарма Коропорейшн
Санофи-Авентис
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Publication of EA201170099A1 publication Critical patent/EA201170099A1/ru

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    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Dermatology (AREA)
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  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
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Abstract

Пиримидоновое производное, представленное формулой (I), или его соль:где Y представляет собой два атома водорода, атом серы, атом кислорода; R1 представляет собой 2-, 3- или 4-пиридиновое кольцо или 2-, 4- или 5-пиримидиновое кольцо, кольцо является необязательно замещенным Cалкильной группой, Cалкоксигруппой или атомом галогена; R2 представляет собой атом водорода, Cалкильную группу или атом галогена; R3 представляет собой фенильную группу, фенил-СН-группу, Cалкил-О-С(О)-группу, фенил-С(О)-группу, 5-10-членную гетероциклическую группу, фенил-СН-O-С(О)-группу, -С (О)-5-10-членную гетероциклическую группу, эти группы являются необязательно замещенными 1-4 заместителями, выбранными из Cалкильной группы, атома галогена, Спергалогенированной алкильной группы, Cгалогенированной алкильной группы, гидроксильной группы, Cалкоксигруппы, Спергалогенированной алкоксигруппы, Cалкилсульфонильной группы, нитро, циано, амино, Cмоноалкиламиногруппы или Сдиалкиламиногруппы, ацетоксигруппы, аминосульфонильной группы; R4 представляет собой атом водорода, атом галогена, гидроксильную группу, Cалкильную группу; m представляет собой 0-2, в форме свободного основания или кислотно-аддитивной соли.
EA201170099A 2008-06-26 2009-06-25 Замещенные пиримидин-4-оновые производные EA201170099A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290613A EP2138492A1 (en) 2008-06-26 2008-06-26 Substituted pyrimidin-4-one derivatives
PCT/IB2009/006576 WO2009156865A1 (en) 2008-06-26 2009-06-25 Substituted pyrimidin-4-one derivatives

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Publication Number Publication Date
EA201170099A1 true EA201170099A1 (ru) 2011-08-30

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Country Status (15)

Country Link
US (1) US8614219B2 (ru)
EP (2) EP2138492A1 (ru)
JP (1) JP5490790B2 (ru)
KR (1) KR20110036917A (ru)
CN (1) CN102076684A (ru)
AR (1) AR072962A1 (ru)
AU (1) AU2009263851A1 (ru)
BR (1) BRPI0914301A2 (ru)
CA (1) CA2728696A1 (ru)
EA (1) EA201170099A1 (ru)
IL (1) IL210172A0 (ru)
MX (1) MX2010013950A (ru)
NZ (1) NZ590046A (ru)
TW (1) TW201004952A (ru)
WO (1) WO2009156865A1 (ru)

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EP2138494A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
EP2138498A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted tricyclic derivatives against neurodegenerative diseases
EP2138488A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP2138495A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138485A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
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TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
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EP2138494A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
EP2138493A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
EP2138488A1 (en) 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases

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AU2009263851A1 (en) 2009-12-30
KR20110036917A (ko) 2011-04-12
JP5490790B2 (ja) 2014-05-14
NZ590046A (en) 2011-11-25
EP2321316A1 (en) 2011-05-18
AR072962A1 (es) 2010-10-06
US8614219B2 (en) 2013-12-24
EP2321316B1 (en) 2014-03-12
TW201004952A (en) 2010-02-01
JP2011525909A (ja) 2011-09-29
CN102076684A (zh) 2011-05-25
MX2010013950A (es) 2011-06-16
EP2138492A1 (en) 2009-12-30
US20110144132A1 (en) 2011-06-16
WO2009156865A1 (en) 2009-12-30
IL210172A0 (en) 2011-03-31
BRPI0914301A2 (pt) 2015-10-13
CA2728696A1 (en) 2009-12-30

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