ME01029B - VIŠESUPTITUISANI DERIVATI 2-ARIL-6-FENIL-IMIDAZO [1, 2α] PIRIDINI, NJIHOVO DOBIJANJE I NJIHOVA UPOTREBA U TERAPIJI - Google Patents

VIŠESUPTITUISANI DERIVATI 2-ARIL-6-FENIL-IMIDAZO [1, 2α] PIRIDINI, NJIHOVO DOBIJANJE I NJIHOVA UPOTREBA U TERAPIJI

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Publication number
ME01029B
ME01029B MEP-2010-155A MEP15510A ME01029B ME 01029 B ME01029 B ME 01029B ME P15510 A MEP15510 A ME P15510A ME 01029 B ME01029 B ME 01029B
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ME
Montenegro
Prior art keywords
optionally substituted
imidazo
therapeutic use
aryl
polysubstituted
Prior art date
Application number
MEP-2010-155A
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English (en)
French (fr)
Inventor
Garcia Antonio Almario
Peretti Danielle De
Yannick Evanno
André Malanda
Patrick Lardenois
Nathalie Rakotoarisoa
Original Assignee
Sanofi Aventis
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39764952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME01029(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ME01029B publication Critical patent/ME01029B/me

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
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    • C07F7/1804—Compounds having Si-O-C linkages

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Public Health (AREA)
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  • Neurology (AREA)
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  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Jedinjenja formule (I):   u kojoj: R 1  predstavlja: heteroaril ili heterocikličnu grupu, koje obe po izboru mogu da budu supstituisane, X predstavlja od 1 do 4 supstituenata, koji su identični ili različiti jedan od drugog, izabrani od vodonika, halogena, (C 1 -C 10 )alkil, halo(C 1 -C 10 )alkoksi, (C 1 -C 10 )alkoksi, NRaRb, cijano ili nitro, R predstavlja, na položaju 3, 5, 7 or 8 imidazo[l, 2-α]piridina, od 1 do 4 substituenta, koji su identični ili različiti jedan od drugog; R 2  i R 3  predstavljaju, nezavisno jedan od drugog, atom vodonika, ili po izboru supstituisanu (C 1 -C 10 )alkil grupu, ili po izboru supstituisanu aril grupu; R 2  i X mogu da formiraju, zajedno sa atomom ugljenika za koji vezani, ugjlenični prsten sa 5 do 7 atoma ugljenika; i R 4  predstavlja: atom vodonika; po izboru supstituisanu (C 1 -C 10 )alkil grupu; ili aril grupu po izboru supstituisanu jednim ili više suostituenata. Terapeutska upotreba ovih jedinjenja i procesi za njihovu sintezu.
MEP-2010-155A 2008-03-21 2009-03-20 VIŠESUPTITUISANI DERIVATI 2-ARIL-6-FENIL-IMIDAZO [1, 2α] PIRIDINI, NJIHOVO DOBIJANJE I NJIHOVA UPOTREBA U TERAPIJI ME01029B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0801581A FR2928922B1 (fr) 2008-03-21 2008-03-21 Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
PCT/FR2009/000302 WO2009144394A1 (fr) 2008-03-21 2009-03-20 Derives de 2-aryl-6-phenyl-imidazo[1,2-a]pyridines polysubstitues, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
ME01029B true ME01029B (me) 2012-10-20

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ID=39764952

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Country Status (23)

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US (1) US8507520B2 (me)
EP (1) EP2262769B1 (me)
JP (1) JP5508385B2 (me)
KR (1) KR20100129775A (me)
CN (2) CN102036959B (me)
AR (1) AR070993A1 (me)
AU (1) AU2009253234B2 (me)
BR (1) BRPI0909415A2 (me)
CA (1) CA2719125C (me)
CL (1) CL2009000696A1 (me)
CO (1) CO6290657A2 (me)
EA (1) EA201071112A1 (me)
FR (1) FR2928922B1 (me)
IL (1) IL208246A0 (me)
MA (1) MA32247B1 (me)
ME (1) ME01029B (me)
MX (1) MX2010010316A (me)
NZ (1) NZ588151A (me)
SG (1) SG189679A1 (me)
TW (1) TW200944202A (me)
UY (1) UY31728A (me)
WO (1) WO2009144394A1 (me)
ZA (1) ZA201006728B (me)

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FR2928924B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
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CN106906486B (zh) * 2017-02-22 2018-12-11 华南理工大学 3-溴-2-苯基-咪唑并[1,2-α]吡啶类衍生物的电化学合成方法
PT3762368T (pt) 2018-03-08 2022-05-06 Incyte Corp Compostos de aminopirazina diol como inibidores de pi3k-y
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MX2020012045A (es) 2018-05-11 2021-03-29 Incyte Corp Derivados de tetrahidro-imidazo[4,5-c]piridina como inmunomoduladores de ligando 1 de muerte programada (pd-l1).
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
MX2022001671A (es) 2019-08-09 2022-05-13 Incyte Corp Sales de un inhibidor de pd-1/pd-l1.
AR120109A1 (es) 2019-09-30 2022-02-02 Incyte Corp Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores
CN114829366A (zh) 2019-11-11 2022-07-29 因赛特公司 Pd-1/pd-l1抑制剂的盐及结晶形式
US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
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FR2928922A1 (fr) 2009-09-25
EP2262769B1 (fr) 2014-11-05
CO6290657A2 (es) 2011-06-20
JP5508385B2 (ja) 2014-05-28
CL2009000696A1 (es) 2010-08-13
NZ588151A (en) 2012-07-27
CA2719125A1 (fr) 2009-12-03
TW200944202A (en) 2009-11-01
KR20100129775A (ko) 2010-12-09
BRPI0909415A2 (pt) 2019-01-15
EP2262769A1 (fr) 2010-12-22
CN102036959A (zh) 2011-04-27
US20110065745A1 (en) 2011-03-17
CN102036959B (zh) 2013-05-22
WO2009144394A1 (fr) 2009-12-03
AU2009253234A1 (en) 2009-12-03
AR070993A1 (es) 2010-05-19
CN103193815A (zh) 2013-07-10
WO2009144394A8 (fr) 2010-10-14
ZA201006728B (en) 2011-11-30
CA2719125C (fr) 2016-07-26
MX2010010316A (es) 2010-12-14
MA32247B1 (fr) 2011-04-01
IL208246A0 (en) 2010-12-30
EA201071112A1 (ru) 2011-04-29
FR2928922B1 (fr) 2010-04-23
AU2009253234B2 (en) 2013-07-11
UY31728A (es) 2009-11-10
US8507520B2 (en) 2013-08-13
JP2011515382A (ja) 2011-05-19
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