ME01098B - VIŠESTRUKO SUPSTITUISANI DERIVATI 2-ARIL-6-FENILIMIDAZO [1,2- α] PIRIDINA, I NJIHOVO DOBIJANJE I TERAPEUTSKA PRIMENA - Google Patents
VIŠESTRUKO SUPSTITUISANI DERIVATI 2-ARIL-6-FENILIMIDAZO [1,2- α] PIRIDINA, I NJIHOVO DOBIJANJE I TERAPEUTSKA PRIMENAInfo
- Publication number
- ME01098B ME01098B MEP-2010-151A MEP15110A ME01098B ME 01098 B ME01098 B ME 01098B ME P15110 A MEP15110 A ME P15110A ME 01098 B ME01098 B ME 01098B
- Authority
- ME
- Montenegro
- Prior art keywords
- group
- alkyl
- optionally substituted
- aryl
- therapeutic use
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Jedinjenja formule (I): (I) u kojoj : R 1 predstavlja: fenilgrupu ili naftil grupu, po izboru supstituisanu jednim ili više atoma iligrupa; X predstavlja od 1 do 4 supstituenta, ista ili koji se razlikuju jedanod drugog, odabrana od halogena, (C 1 -C 10 )alkila, halo(C 1 -C 10 )alkila, (C 1 -C 10 )alkoksi, NRaRb, cijano,nitro, moguće je za (C 1 -C 10 )alkil da bude po izboru supstituisana halogenom ili NRaRb ili hidroksil grupom; R 2 i R 3 predstavljaju, nezavisno jedan od drugog, atom vodonika ili (C 1 -C 10 )alkilgrupu , ova grupa je po izboru supstituisana sa Rf grupom, ili aril grupu, aril je po izboru supstituisan jednim ili više supstituenata odabranih od halogena ili (C 1 -C 10 )alkil, halo(C 1 -C 10 )alkil, (C 1 -C 10 )alkoksi ,halo(C 1 ‑C 10 )alkoksi, NRaRb, hidroksil, nitro ili cijano grupe; R 2 i X mogu zajedno da formiraju, sa atomima ugljenika koji ih nose, ugljenični prsten sa 5 do 7 atoma ugljenika; R 4 predstavlja atomvodonika, (C 1 -C 10 )alkil grupu, po izboru supstituisanu sa Rf grupom, ili po izboru supstituisanu aril grupu, u obliku baze ili adicione soli sa kiselinom. Terapeutska upotreba i proces sinteze.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0801580A FR2928921B1 (fr) | 2008-03-21 | 2008-03-21 | Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique |
| PCT/FR2009/000297 WO2009144391A1 (fr) | 2008-03-21 | 2009-03-20 | DÉRIVÉS POLYSUBSTITUES DE 2-ARYL-6-PHENYL-IMIDAZO[1,2- α]PYRIDINES, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01098B true ME01098B (me) | 2012-12-20 |
Family
ID=39764893
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2010-151A ME01098B (me) | 2008-03-21 | 2009-03-20 | VIŠESTRUKO SUPSTITUISANI DERIVATI 2-ARIL-6-FENILIMIDAZO [1,2- α] PIRIDINA, I NJIHOVO DOBIJANJE I TERAPEUTSKA PRIMENA |
| MEP-2013-4A ME01469B (me) | 2008-03-21 | 2009-03-20 | POLISUPSTITUISANI DERIVATI 2-ARIL-6-FENIL-IMIDAZO[1,2-a]PIRIDINA I NJIHOVO DOBIJANJE I TERAPEUTSKA UPOTREBA |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2013-4A ME01469B (me) | 2008-03-21 | 2009-03-20 | POLISUPSTITUISANI DERIVATI 2-ARIL-6-FENIL-IMIDAZO[1,2-a]PIRIDINA I NJIHOVO DOBIJANJE I TERAPEUTSKA UPOTREBA |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8148370B2 (me) |
| EP (1) | EP2262803B1 (me) |
| JP (1) | JP5508383B2 (me) |
| KR (1) | KR20100129774A (me) |
| CN (1) | CN102036988B (me) |
| AR (1) | AR070992A1 (me) |
| AU (1) | AU2009253231B2 (me) |
| BR (1) | BRPI0908999A8 (me) |
| CA (1) | CA2718953C (me) |
| CL (1) | CL2009000695A1 (me) |
| CO (1) | CO6300865A2 (me) |
| CY (1) | CY1113549T1 (me) |
| DK (1) | DK2262803T3 (me) |
| EA (1) | EA018266B1 (me) |
| ES (1) | ES2397931T3 (me) |
| FR (1) | FR2928921B1 (me) |
| HR (1) | HRP20130029T1 (me) |
| IL (1) | IL208248A0 (me) |
| MA (1) | MA32246B1 (me) |
| ME (2) | ME01098B (me) |
| MX (1) | MX2010010259A (me) |
| NZ (1) | NZ588081A (me) |
| PE (1) | PE20091818A1 (me) |
| PL (1) | PL2262803T3 (me) |
| PT (1) | PT2262803E (me) |
| RS (1) | RS52652B (me) |
| SI (1) | SI2262803T1 (me) |
| TW (1) | TW201000477A (me) |
| UY (1) | UY31727A (me) |
| WO (1) | WO2009144391A1 (me) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| FR2928922B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique |
| FR2928924B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
| FR2953520B1 (fr) * | 2009-12-04 | 2011-11-25 | Sanofi Aventis | Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique |
| EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| HRP20221035T1 (hr) | 2015-11-19 | 2022-11-11 | Incyte Corporation | Heterociklički spojevi kao imunomodulatori |
| PE20230731A1 (es) | 2015-12-22 | 2023-05-03 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores |
| AR108396A1 (es) | 2016-05-06 | 2018-08-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| EP3464279B1 (en) | 2016-05-26 | 2021-11-24 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| TWI771305B (zh) | 2016-06-20 | 2022-07-21 | 美商英塞特公司 | 作為免疫調節劑之雜環化合物 |
| WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20180057486A1 (en) | 2016-08-29 | 2018-03-01 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| PE20200005A1 (es) | 2016-12-22 | 2020-01-06 | Incyte Corp | Derivados de tetrahidro imidazo[4,5-c]piridina como inductores de internalizacion pd-l1 |
| WO2018119221A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| ES2874756T3 (es) | 2016-12-22 | 2021-11-05 | Incyte Corp | Derivados de triazolo[1,5-A]piridina como inmunomoduladores |
| WO2018119266A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
| FI3774791T3 (fi) | 2018-03-30 | 2023-03-21 | Incyte Corp | Heterosyklisiä yhdisteitä immunomodulaattoreina |
| BR112020022936A2 (pt) | 2018-05-11 | 2021-02-02 | Incyte Corporation | derivados de tetra-hidro-imidazo[4,5-c]piridina como imunomoduladores de pd-l1 |
| WO2021030162A1 (en) | 2019-08-09 | 2021-02-18 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| JP7559059B2 (ja) | 2019-09-30 | 2024-10-01 | インサイト・コーポレイション | 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 |
| MX2022005651A (es) | 2019-11-11 | 2022-07-27 | Incyte Corp | Sales y formas cristalinas de un inhibidor de la proteina de muerte celular programada 1 (pd-1)/ligando de muerte celular programada 1 (pd-l1). |
| TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式 |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| KR20230117573A (ko) | 2020-11-06 | 2023-08-08 | 인사이트 코포레이션 | Pd-1 및 pd-l1 억제제, 및 이의 염 및 결정형의 제조 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2903105A1 (fr) * | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
| FR2903106B1 (fr) * | 2006-07-03 | 2010-07-30 | Sanofi Aventis | Utilisations de 2-benzoyl-imidazopyridines en therapeutique |
| FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
| FR2928922B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique |
| FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
-
2008
- 2008-03-21 FR FR0801580A patent/FR2928921B1/fr not_active Expired - Fee Related
-
2009
- 2009-03-19 PE PE2009000415A patent/PE20091818A1/es not_active Application Discontinuation
- 2009-03-19 AR ARP090100985A patent/AR070992A1/es not_active Application Discontinuation
- 2009-03-20 SI SI200930480T patent/SI2262803T1/sl unknown
- 2009-03-20 ES ES09754041T patent/ES2397931T3/es active Active
- 2009-03-20 EP EP09754041A patent/EP2262803B1/fr active Active
- 2009-03-20 UY UY0001031727A patent/UY31727A/es not_active Application Discontinuation
- 2009-03-20 NZ NZ588081A patent/NZ588081A/en not_active IP Right Cessation
- 2009-03-20 CL CL2009000695A patent/CL2009000695A1/es unknown
- 2009-03-20 PT PT97540413T patent/PT2262803E/pt unknown
- 2009-03-20 RS RS20130008A patent/RS52652B/en unknown
- 2009-03-20 ME MEP-2010-151A patent/ME01098B/me unknown
- 2009-03-20 AU AU2009253231A patent/AU2009253231B2/en not_active Ceased
- 2009-03-20 CA CA2718953A patent/CA2718953C/fr not_active Expired - Fee Related
- 2009-03-20 MX MX2010010259A patent/MX2010010259A/es active IP Right Grant
- 2009-03-20 PL PL09754041T patent/PL2262803T3/pl unknown
- 2009-03-20 ME MEP-2013-4A patent/ME01469B/me unknown
- 2009-03-20 JP JP2011500258A patent/JP5508383B2/ja not_active Expired - Fee Related
- 2009-03-20 DK DK09754041.3T patent/DK2262803T3/da active
- 2009-03-20 CN CN2009801185642A patent/CN102036988B/zh not_active Expired - Fee Related
- 2009-03-20 EA EA201071110A patent/EA018266B1/ru not_active IP Right Cessation
- 2009-03-20 BR BRPI0908999A patent/BRPI0908999A8/pt not_active IP Right Cessation
- 2009-03-20 TW TW098109237A patent/TW201000477A/zh unknown
- 2009-03-20 WO PCT/FR2009/000297 patent/WO2009144391A1/fr active Application Filing
- 2009-03-20 KR KR1020107023410A patent/KR20100129774A/ko not_active Application Discontinuation
-
2010
- 2010-09-14 US US12/881,805 patent/US8148370B2/en not_active Expired - Fee Related
- 2010-09-19 IL IL208248A patent/IL208248A0/en unknown
- 2010-09-21 CO CO10116606A patent/CO6300865A2/es not_active Application Discontinuation
- 2010-10-19 MA MA33272A patent/MA32246B1/fr unknown
-
2013
- 2013-01-15 HR HRP20130029AT patent/HRP20130029T1/hr unknown
- 2013-01-17 CY CY20131100052T patent/CY1113549T1/el unknown
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