CO6300865A2 - Derivados polisustituidos de 2 aril-6-fenil-imidazo[1,2-a]piridinas su preparacion y su aplicacion en terapeutica - Google Patents
Derivados polisustituidos de 2 aril-6-fenil-imidazo[1,2-a]piridinas su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6300865A2 CO6300865A2 CO10116606A CO10116606A CO6300865A2 CO 6300865 A2 CO6300865 A2 CO 6300865A2 CO 10116606 A CO10116606 A CO 10116606A CO 10116606 A CO10116606 A CO 10116606A CO 6300865 A2 CO6300865 A2 CO 6300865A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- nrarb
- group
- alkoxy
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
1.- Compuestos de fórmula (I):en la que:R1 representa:un grupo fenilo o un grupo naftilo, pudiendo estar estos dos grupos sustituidos opcionalmente con uno o varios átomos o grupos elegidos independientemente los unos de los otros entre los átomos o grupos siguientes : halógeno, alquilo(C1-C10), haloalquilo(C1-C10), alcoxi(C1-C10), haloalcoxi(C1-C10), tioalquilo(C1-C10), -S(O)alquilo(C1-C10), -S(O)2(alquiloC1-C10), hidroxilo, ciano, nitro, hidroxialquileno(C1-C10), NRaRb-alquileno(C1-C10), alcoxi(C1-C10)alquileno(C1-C10)-oxi, NRaRb, CONRaRb, SO2NRaRb, NRcCORd, OC(O)NRaRb, OCO-alquilo(C1-C10), NRcC(O)ORe, NRcSO2Re, arilalquileno(C1-C10), arilo o heteroarilo monocíclico, estando el arilo o el heteroarilo monocíclico sustituido opcionalmente con uno o varios sustituyentes elegidos entre un halógeno, un grupo alquilo(C1-C10), haloalquilo(C1-C10), alcoxi(C1-C10), haloalcoxi(C1-C10), NRaRb, hidroxilo, oxo, nitro, ciano o OCO-alquilo(C1-C10);X representa de 1 a 4 sustituyentes idénticos o diferentes el uno del otro, elegidos entre halógeno, alquilo(C1-C10), alcoxi(C1-C10), NRaRb, ciano, nitro, pudiendo estar el alquilo(C1-C10) sustituido opcionalmente con uno o varios grupos elegidos entre un halógeno, alcoxi(C1-C10), haloalcoxi(C1-C10), NRaRb o hidroxilo;R2 y R3 representan, independientemente uno de otro, un átomo de hidrógeno, un grupo alquilo(C1-C10), estando este grupo sustituido opcionalmente con un grupo Rf; un grupo arilo, sustituido opcionalmente con uno o varios sustituyentes elegidos entre un halógeno, un grupo alquilo(C1-C10), haloalquilo(C1-C10), alcoxi(C1-C10), haloalcoxi(C1-C10), NRaRb, hidroxilo, nitro o ciano;R2 y X pueden formar juntos con los átomos de carbono a los que están unidos un ciclo carbonado de 5 a 7 átomos de carbono; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0801580A FR2928921B1 (fr) | 2008-03-21 | 2008-03-21 | Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6300865A2 true CO6300865A2 (es) | 2011-07-21 |
Family
ID=39764893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10116606A CO6300865A2 (es) | 2008-03-21 | 2010-09-21 | Derivados polisustituidos de 2 aril-6-fenil-imidazo[1,2-a]piridinas su preparacion y su aplicacion en terapeutica |
Country Status (30)
Country | Link |
---|---|
US (1) | US8148370B2 (es) |
EP (1) | EP2262803B1 (es) |
JP (1) | JP5508383B2 (es) |
KR (1) | KR20100129774A (es) |
CN (1) | CN102036988B (es) |
AR (1) | AR070992A1 (es) |
AU (1) | AU2009253231B2 (es) |
BR (1) | BRPI0908999A8 (es) |
CA (1) | CA2718953C (es) |
CL (1) | CL2009000695A1 (es) |
CO (1) | CO6300865A2 (es) |
CY (1) | CY1113549T1 (es) |
DK (1) | DK2262803T3 (es) |
EA (1) | EA018266B1 (es) |
ES (1) | ES2397931T3 (es) |
FR (1) | FR2928921B1 (es) |
HR (1) | HRP20130029T1 (es) |
IL (1) | IL208248A0 (es) |
MA (1) | MA32246B1 (es) |
ME (2) | ME01469B (es) |
MX (1) | MX2010010259A (es) |
NZ (1) | NZ588081A (es) |
PE (1) | PE20091818A1 (es) |
PL (1) | PL2262803T3 (es) |
PT (1) | PT2262803E (es) |
RS (1) | RS52652B (es) |
SI (1) | SI2262803T1 (es) |
TW (1) | TW201000477A (es) |
UY (1) | UY31727A (es) |
WO (1) | WO2009144391A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
FR2928922B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique |
FR2928924B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
FR2953520B1 (fr) * | 2009-12-04 | 2011-11-25 | Sanofi Aventis | Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique |
US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2017087777A1 (en) | 2015-11-19 | 2017-05-26 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
MX2018007774A (es) | 2015-12-22 | 2018-11-09 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores. |
ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
TW201808902A (zh) | 2016-05-26 | 2018-03-16 | 美商英塞特公司 | 作為免疫調節劑之雜環化合物 |
IL263825B (en) | 2016-06-20 | 2022-08-01 | Incyte Corp | Heterocyclic compounds as immunomodulators |
WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
CA3047986A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
CA3047980A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
RS64055B1 (sr) | 2018-03-30 | 2023-04-28 | Incyte Corp | Heterociklična jedinjenja kao imunomodulatori |
EP4219492A1 (en) | 2018-05-11 | 2023-08-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
JP2022544189A (ja) | 2019-08-09 | 2022-10-17 | インサイト・コーポレイション | Pd-1/pd-l1阻害剤の塩 |
CA3155852A1 (en) | 2019-09-30 | 2021-04-08 | Incyte Corporation | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AS IMMUNOMODULATORS |
JP2023500395A (ja) | 2019-11-11 | 2023-01-05 | インサイト・コーポレイション | Pd-1/pd-l1阻害剤の塩及び結晶形態 |
US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
KR20230117573A (ko) | 2020-11-06 | 2023-08-08 | 인사이트 코포레이션 | Pd-1 및 pd-l1 억제제, 및 이의 염 및 결정형의 제조 방법 |
US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2903106B1 (fr) * | 2006-07-03 | 2010-07-30 | Sanofi Aventis | Utilisations de 2-benzoyl-imidazopyridines en therapeutique |
FR2903105A1 (fr) * | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
FR2928922B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique |
FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
-
2008
- 2008-03-21 FR FR0801580A patent/FR2928921B1/fr not_active Expired - Fee Related
-
2009
- 2009-03-19 AR ARP090100985A patent/AR070992A1/es not_active Application Discontinuation
- 2009-03-19 PE PE2009000415A patent/PE20091818A1/es not_active Application Discontinuation
- 2009-03-20 EA EA201071110A patent/EA018266B1/ru not_active IP Right Cessation
- 2009-03-20 JP JP2011500258A patent/JP5508383B2/ja not_active Expired - Fee Related
- 2009-03-20 SI SI200930480T patent/SI2262803T1/sl unknown
- 2009-03-20 BR BRPI0908999A patent/BRPI0908999A8/pt not_active IP Right Cessation
- 2009-03-20 CN CN2009801185642A patent/CN102036988B/zh not_active Expired - Fee Related
- 2009-03-20 ES ES09754041T patent/ES2397931T3/es active Active
- 2009-03-20 ME MEP-2013-4A patent/ME01469B/me unknown
- 2009-03-20 KR KR1020107023410A patent/KR20100129774A/ko not_active Application Discontinuation
- 2009-03-20 CL CL2009000695A patent/CL2009000695A1/es unknown
- 2009-03-20 ME MEP-2010-151A patent/ME01098B/me unknown
- 2009-03-20 TW TW098109237A patent/TW201000477A/zh unknown
- 2009-03-20 WO PCT/FR2009/000297 patent/WO2009144391A1/fr active Application Filing
- 2009-03-20 AU AU2009253231A patent/AU2009253231B2/en not_active Ceased
- 2009-03-20 CA CA2718953A patent/CA2718953C/fr not_active Expired - Fee Related
- 2009-03-20 PT PT97540413T patent/PT2262803E/pt unknown
- 2009-03-20 DK DK09754041.3T patent/DK2262803T3/da active
- 2009-03-20 NZ NZ588081A patent/NZ588081A/en not_active IP Right Cessation
- 2009-03-20 MX MX2010010259A patent/MX2010010259A/es active IP Right Grant
- 2009-03-20 RS RS20130008A patent/RS52652B/en unknown
- 2009-03-20 PL PL09754041T patent/PL2262803T3/pl unknown
- 2009-03-20 UY UY0001031727A patent/UY31727A/es not_active Application Discontinuation
- 2009-03-20 EP EP09754041A patent/EP2262803B1/fr active Active
-
2010
- 2010-09-14 US US12/881,805 patent/US8148370B2/en not_active Expired - Fee Related
- 2010-09-19 IL IL208248A patent/IL208248A0/en unknown
- 2010-09-21 CO CO10116606A patent/CO6300865A2/es not_active Application Discontinuation
- 2010-10-19 MA MA33272A patent/MA32246B1/fr unknown
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2013
- 2013-01-15 HR HRP20130029AT patent/HRP20130029T1/hr unknown
- 2013-01-17 CY CY20131100052T patent/CY1113549T1/el unknown
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Legal Events
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