MX2009004920A - Nuevos derivados de aminopirimidina como inhibidores de plk1. - Google Patents

Nuevos derivados de aminopirimidina como inhibidores de plk1.

Info

Publication number
MX2009004920A
MX2009004920A MX2009004920A MX2009004920A MX2009004920A MX 2009004920 A MX2009004920 A MX 2009004920A MX 2009004920 A MX2009004920 A MX 2009004920A MX 2009004920 A MX2009004920 A MX 2009004920A MX 2009004920 A MX2009004920 A MX 2009004920A
Authority
MX
Mexico
Prior art keywords
lower alkyl
alkyl group
group
substituted
hydrogen atom
Prior art date
Application number
MX2009004920A
Other languages
English (en)
Inventor
Morihiro Mitsuya
Takashi Hashihayata
Mikako Kawamura
Yoshiyuki Satoh
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of MX2009004920A publication Critical patent/MX2009004920A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a un compuesto representado por la Fórmula [I] (ver fórmula I) o una sal farmacéuticamente aceptable o éster del mismo, donde cada uno de R1 y R2, que pueden ser iguales o diferentes, es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo inferior que puede estar sustituido, o un grupo ciclopropilo; cada uno de R3 y R4, que pueden ser iguales o diferentes, es un átomo de hidrógeno, un grupo alquilo inferior sustituido con NRaRb, un grupo heterocíclico alifático de 4 a 6 miembros, un grupo alquilo inferior sustituido con un grupo heterocíclico alifático de 4 a 6 miembros, un grupo heterocíclico aromático de 5 ó 6 miembros, o un grupo alquilo inferior sustituido con un grupo heterocíclico aromático de 5 ó 6 miembros; y R5 es un átomo de hidrógeno, un grupo ciano, un átomo de halógeno, o un grupo alquilo inferior.
MX2009004920A 2006-12-28 2007-12-20 Nuevos derivados de aminopirimidina como inhibidores de plk1. MX2009004920A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006356575 2006-12-28
JP2007265783 2007-10-11
PCT/JP2007/075224 WO2008081910A1 (en) 2006-12-28 2007-12-20 Novel aminopyrimidine derivatives as plk1 inhibitors

Publications (1)

Publication Number Publication Date
MX2009004920A true MX2009004920A (es) 2009-05-21

Family

ID=39588592

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004920A MX2009004920A (es) 2006-12-28 2007-12-20 Nuevos derivados de aminopirimidina como inhibidores de plk1.

Country Status (24)

Country Link
US (1) US7977336B2 (es)
EP (2) EP2116543A4 (es)
JP (1) JPWO2008081914A1 (es)
KR (1) KR101481388B1 (es)
CN (1) CN101573361B (es)
AR (1) AR064619A1 (es)
AU (1) AU2007340530B2 (es)
BR (1) BRPI0718966B8 (es)
CA (1) CA2668738A1 (es)
CL (1) CL2007003758A1 (es)
CO (1) CO6190523A2 (es)
CR (1) CR10784A (es)
EC (1) ECSP099324A (es)
GT (1) GT200900124A (es)
IL (1) IL198675A0 (es)
MA (1) MA31109B1 (es)
MX (1) MX2009004920A (es)
NO (1) NO20092770L (es)
NZ (1) NZ577273A (es)
PE (1) PE20081845A1 (es)
RU (1) RU2458062C2 (es)
SV (1) SV2009003258A (es)
TW (1) TW200835485A (es)
WO (2) WO2008081910A1 (es)

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JP6426603B2 (ja) 2012-06-26 2018-11-21 ヤンセン ファーマシューティカ エヌ．ベー． 神経障害または代謝障害の治療に使用するための、１−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］−キノキサリン化合物などのＰＤＥ２阻害剤とＰＤＥ１０阻害剤との組合せ
ES2607184T3 (es) 2012-07-09 2017-03-29 Janssen Pharmaceutica, N.V. Inhibidores de la enzima fosfodiesterasa 10
JP6324381B2 (ja) 2012-07-31 2018-05-16 クラウン バイオサイエンス インコーポレイテッド（タイカン） 抗ｅｇｆｒ薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー
WO2014046617A1 (en) * 2012-09-19 2014-03-27 Agency For Science, Technology And Research Compositions and methods for treating cancer
EP3194367B1 (en) 2014-09-17 2021-08-18 Boehringer Ingelheim International GmbH Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes
WO2021003517A1 (en) * 2019-07-10 2021-01-14 Aucentra Therapeutics Pty Ltd Derivatives of 4-(imidazo[l,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin- 2-amine as therapeutic agents
CN112592318B (zh) * 2020-12-12 2022-05-03 贵州医科大学 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用

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Also Published As

Publication number Publication date
PE20081845A1 (es) 2008-12-27
RU2009128966A (ru) 2011-02-10
BRPI0718966B8 (pt) 2021-05-25
CN101573361B (zh) 2012-05-30
AU2007340530B2 (en) 2012-09-13
WO2008081914A1 (ja) 2008-07-10
CR10784A (es) 2009-09-16
BRPI0718966B1 (pt) 2020-11-17
WO2008081910A1 (en) 2008-07-10
CL2007003758A1 (es) 2008-07-04
EP2116543A4 (en) 2010-09-08
CO6190523A2 (es) 2010-08-19
US7977336B2 (en) 2011-07-12
ECSP099324A (es) 2009-06-30
NZ577273A (en) 2011-03-31
EP2114942B1 (en) 2012-10-31
EP2114942A1 (en) 2009-11-11
NO20092770L (no) 2009-09-25
EP2116543A1 (en) 2009-11-11
AU2007340530A1 (en) 2008-07-10
MA31109B1 (fr) 2010-01-04
BRPI0718966A2 (pt) 2014-01-07
CN101573361A (zh) 2009-11-04
GT200900124A (es) 2010-11-03
KR20090092822A (ko) 2009-09-01
AR064619A1 (es) 2009-04-15
JPWO2008081914A1 (ja) 2010-04-30
SV2009003258A (es) 2010-08-23
CA2668738A1 (en) 2008-07-10
US20080305081A1 (en) 2008-12-11
KR101481388B1 (ko) 2015-01-12
TW200835485A (en) 2008-09-01
EP2114942A4 (en) 2010-09-08
RU2458062C2 (ru) 2012-08-10
IL198675A0 (en) 2010-02-17

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