CO6190523A2 - Nuevos derivados de aminopirimidina como inhibidores de plk1 - Google Patents
Nuevos derivados de aminopirimidina como inhibidores de plk1Info
- Publication number
- CO6190523A2 CO6190523A2 CO09048000A CO09048000A CO6190523A2 CO 6190523 A2 CO6190523 A2 CO 6190523A2 CO 09048000 A CO09048000 A CO 09048000A CO 09048000 A CO09048000 A CO 09048000A CO 6190523 A2 CO6190523 A2 CO 6190523A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- lower alkyl
- substituted
- alkyl group
- different
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- Un compuesto de Fórmula (I):o una sal farmacéuticamente aceptable o éster del mismo, donde: cada uno de R1 y R2, que pueden ser iguales o diferentes, es un átomo de hidrógeno; un átomo de halógeno; un grupo alquilo inferior que tiene de uno a dos átomos de carbono, que puede estar sustituido con de uno a tres átomos de flúor; o un grupo ciclopropilo; uno de R3 y R4 es un átomo de hidrógeno, mientras que el otro de R3 y R4 es: a) un grupo alquilo inferior sustituido con NRaRb, donde cada uno de Ra y Rb, que pueden ser iguales o diferentes, es un átomo de hidrógeno, un grupo alquilo inferior, un grupo bencilo, o un grupo cicloalquilo que tiene de tres a seis átomos de carbono, donde el grupo cicloalquilo puede estar sustituido con uno o más sustituyentes, que pueden ser iguales o diferentes, seleccionados entre los siguientes 1) a 3): un grupo alquilo inferior; 2) un sustituyente seleccionado entre el ; y 3) un grupo alquilo inferior sustituido con uno o más sustituyentes seleccionados entre el ; y el grupo cicloalquilo puede incluir un enlace insaturado; b) un grupo heterocíclico alifático de 4 a 6 miembros seleccionado entre un grupo azetidinilo, un grupo pirrolidinilo, un grupo piperidinilo, y un grupo piperazinilo; c) un grupo alquilo inferior sustituido con un grupo heterocíclico alifático de 4 a 6 miembros seleccionado entre un grupo azetidinilo, un grupo pirrolidinilo, un grupo piperidinilo, y un grupo piperazinilo, d) un grupo heterocíclico aromático de 5 ó 6 miembros seleccionado entre un grupo pirrolilo, un grupo imidazolilo, un grupo pirazolilo, un grupo piridilo, un grupo pirazinilo, y un grupo pirimidinilo; o ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006356575 | 2006-12-28 | ||
| JP2007265783 | 2007-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6190523A2 true CO6190523A2 (es) | 2010-08-19 |
Family
ID=39588592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09048000A CO6190523A2 (es) | 2006-12-28 | 2009-05-12 | Nuevos derivados de aminopirimidina como inhibidores de plk1 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7977336B2 (es) |
| EP (2) | EP2116543A4 (es) |
| JP (1) | JPWO2008081914A1 (es) |
| KR (1) | KR101481388B1 (es) |
| CN (1) | CN101573361B (es) |
| AR (1) | AR064619A1 (es) |
| AU (1) | AU2007340530B2 (es) |
| BR (1) | BRPI0718966B8 (es) |
| CA (1) | CA2668738A1 (es) |
| CL (1) | CL2007003758A1 (es) |
| CO (1) | CO6190523A2 (es) |
| CR (1) | CR10784A (es) |
| EC (1) | ECSP099324A (es) |
| GT (1) | GT200900124A (es) |
| IL (1) | IL198675A0 (es) |
| MA (1) | MA31109B1 (es) |
| MX (1) | MX2009004920A (es) |
| NO (1) | NO20092770L (es) |
| NZ (1) | NZ577273A (es) |
| PE (1) | PE20081845A1 (es) |
| RU (1) | RU2458062C2 (es) |
| SV (1) | SV2009003258A (es) |
| TW (1) | TW200835485A (es) |
| WO (2) | WO2008081910A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2114941B1 (en) | 2006-12-22 | 2015-03-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| AU2007337895C1 (en) | 2006-12-22 | 2014-07-31 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010013633A1 (ja) * | 2008-07-31 | 2010-02-04 | 萬有製薬株式会社 | 細胞のｒｂステイタス及びｐｌｋ１阻害剤に対する感受性を予測する方法 |
| JP4489132B2 (ja) * | 2008-08-22 | 2010-06-23 | 株式会社東芝 | 磁気記録媒体の製造方法 |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| US8445674B2 (en) | 2009-10-21 | 2013-05-21 | Hoffmann-La Roche Inc | Heterocyclyl compounds |
| EP2493889B1 (en) | 2009-10-30 | 2017-09-06 | Janssen Pharmaceutica, N.V. | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
| UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
| AU2012277912B2 (en) | 2011-06-27 | 2017-03-23 | Janssen Pharmaceutica Nv | 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives |
| EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
| CU24269B1 (es) | 2011-09-27 | 2017-08-08 | Novartis Ag | 3- pirimidin- 4-il- oxazolidin- 2- onas inhibidores de la idh mutante |
| EP2863909B1 (en) | 2012-06-26 | 2020-11-04 | Janssen Pharmaceutica N.V. | Combinations comprising 4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline compounds as pde 2 inhibitors and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| MX362197B (es) | 2012-07-09 | 2019-01-08 | Janssen Pharmaceutica Nv | Derivados de imidazo[1,2-b]piridazina e imidazo[1,2-a]pirazina como inhibidores de la fosfodiesterasa 10; y el uso de los mismos en el tratamiento de trastornos neurológicos, psiquiátricos y metabólicos. |
| ES2668861T3 (es) | 2012-07-31 | 2018-05-22 | Crown Bioscience, Inc. (Taicang) | Marcadores histológicos para identificar pacientes con carcinoma de pulmón de células no pequeñas para el tratamiento con un fármaco anti EGFR |
| WO2014046617A1 (en) * | 2012-09-19 | 2014-03-27 | Agency For Science, Technology And Research | Compositions and methods for treating cancer |
| WO2016041845A1 (en) | 2014-09-17 | 2016-03-24 | Boehringer Ingelheim International Gmbh | Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes |
| EP3997088A4 (en) * | 2019-07-10 | 2022-12-28 | Aucentra Therapeutics Pty Ltd | DERIVATIVES OF 4-(IMIDAZO[L,2-A]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS |
| CN112592318B (zh) * | 2020-12-12 | 2022-05-03 | 贵州医科大学 | 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5223608A (en) | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| FI95708C (fi) | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi |
| JPH045029A (ja) | 1990-04-23 | 1992-01-09 | Bridgestone Corp | 空気入りタイヤ |
| DE69131775T2 (de) | 1990-09-28 | 2000-04-20 | Smithkline Beecham Corp. | Verfahren zur Herstellung wasserlöslicher Camptothecinanaloge, sowie die Verbindungen 10-Hydroxy-11-C(1-6)-alkoxycamptothecin |
| US5243050A (en) | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5162532A (en) | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
| US5247089A (en) | 1990-12-20 | 1993-09-21 | North Carolina State University | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5191082A (en) | 1990-12-20 | 1993-03-02 | North Carolina State University | Camptothecin intermediate and method of making camptothecin intermediates |
| US5200524A (en) | 1990-12-20 | 1993-04-06 | North Carolina State University | Camptothecin intermediates and method of making same |
| DE69233803D1 (de) | 1992-10-28 | 2011-03-31 | Genentech Inc | Verwendung von vaskulären Endothelwachstumsfaktor-Antagonisten |
| JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| CA2222231A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス．アー． | 白金化合物の製造方法 |
| PT1140939E (pt) * | 1999-11-10 | 2005-05-31 | Ortho Mcneil Pharm Inc | 2-aril-3-(heteroaril)- imidazo [1,2-alfa] pirimidinas substituidas, e formulacoes farmaceuticas e metodos relacionados |
| AU2002237704A1 (en) | 2000-12-04 | 2002-06-18 | Sepracor, Inc. | Methods for the stereoselective synthesis of substituted piperidines |
| US7196095B2 (en) | 2001-06-25 | 2007-03-27 | Merck & Co., Inc. | (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds |
| WO2003011285A1 (en) | 2001-08-01 | 2003-02-13 | Merck & Co., Inc. | BENZIMIDAZO[4,5-f]ISOQUINOLINONE DERIVATIVES |
| UA80296C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
| WO2004043936A1 (ja) | 2002-11-14 | 2004-05-27 | Kyowa Hakko Kogyo Co., Ltd. | Ｐｌｋ阻害剤 |
| CA2559733C (en) | 2004-03-26 | 2014-05-13 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP1790650B1 (en) | 2004-08-31 | 2014-03-26 | Msd Kk | NEW SUBSTITUTED IMIDAZOLE DERIVATIVES |
-
2007
- 2007-12-18 US US12/002,546 patent/US7977336B2/en active Active
- 2007-12-20 CN CN2007800488795A patent/CN101573361B/zh active Active
- 2007-12-20 CA CA002668738A patent/CA2668738A1/en not_active Abandoned
- 2007-12-20 BR BRPI0718966A patent/BRPI0718966B8/pt active IP Right Grant
- 2007-12-20 JP JP2008552168A patent/JPWO2008081914A1/ja not_active Ceased
- 2007-12-20 AR ARP070105784A patent/AR064619A1/es not_active Application Discontinuation
- 2007-12-20 AU AU2007340530A patent/AU2007340530B2/en active Active
- 2007-12-20 CL CL200703758A patent/CL2007003758A1/es unknown
- 2007-12-20 TW TW096149071A patent/TW200835485A/zh unknown
- 2007-12-20 EP EP07851126A patent/EP2116543A4/en not_active Withdrawn
- 2007-12-20 WO PCT/JP2007/075224 patent/WO2008081910A1/en active Application Filing
- 2007-12-20 EP EP07851112A patent/EP2114942B1/en active Active
- 2007-12-20 RU RU2009128966/04A patent/RU2458062C2/ru active
- 2007-12-20 KR KR1020097013324A patent/KR101481388B1/ko active IP Right Grant
- 2007-12-20 NZ NZ577273A patent/NZ577273A/en not_active IP Right Cessation
- 2007-12-20 MX MX2009004920A patent/MX2009004920A/es active IP Right Grant
- 2007-12-20 WO PCT/JP2007/075240 patent/WO2008081914A1/ja active Application Filing
-
2008
- 2008-01-02 PE PE2008000054A patent/PE20081845A1/es not_active Application Discontinuation
-
2009
- 2009-05-08 CR CR10784A patent/CR10784A/es not_active Application Discontinuation
- 2009-05-10 IL IL198675A patent/IL198675A0/en unknown
- 2009-05-12 SV SV2009003258A patent/SV2009003258A/es active IP Right Grant
- 2009-05-12 CO CO09048000A patent/CO6190523A2/es not_active Application Discontinuation
- 2009-05-12 EC EC2009009324A patent/ECSP099324A/es unknown
- 2009-05-12 GT GT200900124A patent/GT200900124A/es unknown
- 2009-07-23 MA MA32115A patent/MA31109B1/fr unknown
- 2009-07-27 NO NO20092770A patent/NO20092770L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |