GT200900124A - Nuevos derivados de aminopirimidina como inhibidores de plk1 - Google Patents
Nuevos derivados de aminopirimidina como inhibidores de plk1Info
- Publication number
- GT200900124A GT200900124A GT200900124A GT200900124A GT200900124A GT 200900124 A GT200900124 A GT 200900124A GT 200900124 A GT200900124 A GT 200900124A GT 200900124 A GT200900124 A GT 200900124A GT 200900124 A GT200900124 A GT 200900124A
- Authority
- GT
- Guatemala
- Prior art keywords
- aminopirimidine
- new derivatives
- plk1 inhibitors
- plk1
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
LA PRESENTE INVENCION SE REFIERE A UN NUEVO DERIVADO DE AMINOPIRIDINA SUSTITUIDO UTIL EN EL CAMPO DE LA MEDICINA, QUE INHIBE LA PROLIFERACION DE CELULAS TUMORALES SOBRE LA BASE DE UN EFECTO INHIBIDOR CONTRA PLK1, DEMOSTRANDO DE ESTA MANERA UN EFECTO ANTITUMORAL Y A UN INHIBIDOR DE PLK1 Y UN AGENTE ANTITUMORAL QUE CONTIENE EL DERIVADO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006356575 | 2006-12-28 | ||
JP2007265783 | 2007-10-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200900124A true GT200900124A (es) | 2010-11-03 |
Family
ID=39588592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200900124A GT200900124A (es) | 2006-12-28 | 2009-05-12 | Nuevos derivados de aminopirimidina como inhibidores de plk1 |
Country Status (24)
Country | Link |
---|---|
US (1) | US7977336B2 (es) |
EP (2) | EP2114942B1 (es) |
JP (1) | JPWO2008081914A1 (es) |
KR (1) | KR101481388B1 (es) |
CN (1) | CN101573361B (es) |
AR (1) | AR064619A1 (es) |
AU (1) | AU2007340530B2 (es) |
BR (1) | BRPI0718966B8 (es) |
CA (1) | CA2668738A1 (es) |
CL (1) | CL2007003758A1 (es) |
CO (1) | CO6190523A2 (es) |
CR (1) | CR10784A (es) |
EC (1) | ECSP099324A (es) |
GT (1) | GT200900124A (es) |
IL (1) | IL198675A0 (es) |
MA (1) | MA31109B1 (es) |
MX (1) | MX2009004920A (es) |
NO (1) | NO20092770L (es) |
NZ (1) | NZ577273A (es) |
PE (1) | PE20081845A1 (es) |
RU (1) | RU2458062C2 (es) |
SV (1) | SV2009003258A (es) |
TW (1) | TW200835485A (es) |
WO (2) | WO2008081914A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009006706A (es) | 2006-12-22 | 2009-07-02 | Astex Therapeutics Ltd | Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos. |
WO2008078100A2 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
WO2010013633A1 (ja) * | 2008-07-31 | 2010-02-04 | 萬有製薬株式会社 | 細胞のrbステイタス及びplk1阻害剤に対する感受性を予測する方法 |
JP4489132B2 (ja) * | 2008-08-22 | 2010-06-23 | 株式会社東芝 | 磁気記録媒体の製造方法 |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
US8445674B2 (en) | 2009-10-21 | 2013-05-21 | Hoffmann-La Roche Inc | Heterocyclyl compounds |
US20120220581A1 (en) | 2009-10-30 | 2012-08-30 | Janssen-Cilag, S.A. | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
WO2013000924A1 (en) | 2011-06-27 | 2013-01-03 | Janssen Pharmaceutica Nv | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES |
EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
CA2849995A1 (en) | 2011-09-27 | 2013-04-04 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
RU2657540C2 (ru) | 2012-06-26 | 2018-06-14 | Янссен Фармацевтика Нв | Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств |
CA2875057C (en) | 2012-07-09 | 2021-07-13 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyrazine compounds and their use as inhibitors of the phosphodiesterase 10 enzyme |
WO2014028221A1 (en) | 2012-07-31 | 2014-02-20 | Crown Bioscience, Inc. | Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug |
WO2014046617A1 (en) * | 2012-09-19 | 2014-03-27 | Agency For Science, Technology And Research | Compositions and methods for treating cancer |
WO2016041845A1 (en) | 2014-09-17 | 2016-03-24 | Boehringer Ingelheim International Gmbh | Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes |
AU2020311297A1 (en) * | 2019-07-10 | 2022-02-03 | Aucentra Therapeutics Pty Ltd | DERIVATIVES OF 4-(IMIDAZO[l,2-a]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN- 2-AMINE AS THERAPEUTIC AGENTS |
CN112592318B (zh) * | 2020-12-12 | 2022-05-03 | 贵州医科大学 | 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
US5223608A (en) | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
FI95708C (fi) | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi |
JPH045029A (ja) | 1990-04-23 | 1992-01-09 | Bridgestone Corp | 空気入りタイヤ |
HUT70024A (en) | 1990-09-28 | 1995-09-28 | Smithkline Beecham Corp | Process for preparing water soluble camptothecin analogs |
US5191082A (en) | 1990-12-20 | 1993-03-02 | North Carolina State University | Camptothecin intermediate and method of making camptothecin intermediates |
US5162532A (en) | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
US5200524A (en) | 1990-12-20 | 1993-04-06 | North Carolina State University | Camptothecin intermediates and method of making same |
US5247089A (en) | 1990-12-20 | 1993-09-21 | North Carolina State University | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs |
US5243050A (en) | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
ES2278663T3 (es) | 1992-10-28 | 2007-08-16 | Genentech, Inc. | Antagonistas del factor de crecimiento de celulas endoteliales vasculares vegf. |
JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス.アー. | 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法 |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
WO1996040210A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス.アー. | 白金化合物の製造方法 |
PT1140939E (pt) * | 1999-11-10 | 2005-05-31 | Ortho Mcneil Pharm Inc | 2-aril-3-(heteroaril)- imidazo [1,2-alfa] pirimidinas substituidas, e formulacoes farmaceuticas e metodos relacionados |
WO2002046157A2 (en) | 2000-12-04 | 2002-06-13 | Sepracor, Inc. | Methods for the stereoselective synthesis of substituted piperidines |
US7196095B2 (en) | 2001-06-25 | 2007-03-27 | Merck & Co., Inc. | (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds |
WO2003011285A1 (en) | 2001-08-01 | 2003-02-13 | Merck & Co., Inc. | BENZIMIDAZO[4,5-f]ISOQUINOLINONE DERIVATIVES |
UA80296C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
WO2004043936A1 (ja) | 2002-11-14 | 2004-05-27 | Kyowa Hakko Kogyo Co., Ltd. | Plk阻害剤 |
AU2005225471B2 (en) | 2004-03-26 | 2011-05-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
JP4972804B2 (ja) * | 2004-08-31 | 2012-07-11 | Msd株式会社 | 新規置換イミダゾール誘導体 |
-
2007
- 2007-12-18 US US12/002,546 patent/US7977336B2/en active Active
- 2007-12-20 WO PCT/JP2007/075240 patent/WO2008081914A1/ja active Application Filing
- 2007-12-20 NZ NZ577273A patent/NZ577273A/en not_active IP Right Cessation
- 2007-12-20 WO PCT/JP2007/075224 patent/WO2008081910A1/en active Application Filing
- 2007-12-20 CL CL200703758A patent/CL2007003758A1/es unknown
- 2007-12-20 EP EP07851112A patent/EP2114942B1/en active Active
- 2007-12-20 CA CA002668738A patent/CA2668738A1/en not_active Abandoned
- 2007-12-20 JP JP2008552168A patent/JPWO2008081914A1/ja not_active Ceased
- 2007-12-20 TW TW096149071A patent/TW200835485A/zh unknown
- 2007-12-20 CN CN2007800488795A patent/CN101573361B/zh active Active
- 2007-12-20 KR KR1020097013324A patent/KR101481388B1/ko active IP Right Grant
- 2007-12-20 BR BRPI0718966A patent/BRPI0718966B8/pt active IP Right Grant
- 2007-12-20 RU RU2009128966/04A patent/RU2458062C2/ru active
- 2007-12-20 AU AU2007340530A patent/AU2007340530B2/en active Active
- 2007-12-20 EP EP07851126A patent/EP2116543A4/en not_active Withdrawn
- 2007-12-20 AR ARP070105784A patent/AR064619A1/es not_active Application Discontinuation
- 2007-12-20 MX MX2009004920A patent/MX2009004920A/es active IP Right Grant
-
2008
- 2008-01-02 PE PE2008000054A patent/PE20081845A1/es not_active Application Discontinuation
-
2009
- 2009-05-08 CR CR10784A patent/CR10784A/es not_active Application Discontinuation
- 2009-05-10 IL IL198675A patent/IL198675A0/en unknown
- 2009-05-12 SV SV2009003258A patent/SV2009003258A/es active IP Right Grant
- 2009-05-12 EC EC2009009324A patent/ECSP099324A/es unknown
- 2009-05-12 CO CO09048000A patent/CO6190523A2/es not_active Application Discontinuation
- 2009-05-12 GT GT200900124A patent/GT200900124A/es unknown
- 2009-07-23 MA MA32115A patent/MA31109B1/fr unknown
- 2009-07-27 NO NO20092770A patent/NO20092770L/no not_active Application Discontinuation
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