BRPI0909415A2 - derivados poli-substituídos de 2-aril -6-fenil-imidazo [1,2-a] piridinas poli-substituídos, o respectivo preparo e a prespectiva aplicação em terapêutica - Google Patents

derivados poli-substituídos de 2-aril -6-fenil-imidazo [1,2-a] piridinas poli-substituídos, o respectivo preparo e a prespectiva aplicação em terapêutica

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Publication number
BRPI0909415A2
BRPI0909415A2 BRPI0909415A BRPI0909415A BRPI0909415A2 BR PI0909415 A2 BRPI0909415 A2 BR PI0909415A2 BR PI0909415 A BRPI0909415 A BR PI0909415A BR PI0909415 A BRPI0909415 A BR PI0909415A BR PI0909415 A2 BRPI0909415 A2 BR PI0909415A2
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BR
Brazil
Prior art keywords
substituted
poly
imidazo
phenyl
aryl
Prior art date
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BRPI0909415A
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English (en)
Inventor
Malanda André
Almario Garcia Antonio
De Peretti Danielle
Rakotoarisoa Nathalie
Lardenois Patrick
Evanno Yannick
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Sanofi Aventis
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39764952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0909415(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0909415A2 publication Critical patent/BRPI0909415A2/pt

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

derivados poli-substituídos de 2-aril -6- fenil-imidazo [1 ,2- a] piridinas poli-substituídos, o respectivo preparo e a respectiva aplicação em terapêutica compostos de fórmula (1): na qual: r1 representa: um grupo fenila ou um grupo naftila, esses dois grupos podendo eventualmente ser substituídos; x representa de 1 a 4 substituintes idênticos ou diferentes um do outro escolhido dentre hidrogênio, halogênio, (c1-c10) alquila, halo (c1-c10) alquila, (c1-c10) alcóxi, nrarb, ciano, nitro; r representa em posição 3, 5, 7, 8 do imidazo [1,2-a] piridina de 1 a 4 substituintes idênticos ou diferentes um do outro; rz e r3 representam, independentemente um do outro, um átomo de hidrogênio, um grupo (c1-c10) alquila eventualmente substituído; um grupo arila eventualmente substituído; r2 e x podem formar juntos com os átomos de carbono que os portam um ciclo carbonado de 5 a 7 átomos de carbono; r4 representa um átomo de hidrogênio, um grupo (c1-c10) alquila eventualmente substituído, ou um grupo arila, eventualmente substituído por um ou vários substituintes. utilização em terapêutica e processo de síntese.
BRPI0909415A 2008-03-21 2009-03-20 derivados poli-substituídos de 2-aril -6-fenil-imidazo [1,2-a] piridinas poli-substituídos, o respectivo preparo e a prespectiva aplicação em terapêutica BRPI0909415A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0801581A FR2928922B1 (fr) 2008-03-21 2008-03-21 Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
PCT/FR2009/000302 WO2009144394A1 (fr) 2008-03-21 2009-03-20 Derives de 2-aryl-6-phenyl-imidazo[1,2-a]pyridines polysubstitues, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
BRPI0909415A2 true BRPI0909415A2 (pt) 2019-01-15

Family

ID=39764952

Family Applications (1)

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BRPI0909415A BRPI0909415A2 (pt) 2008-03-21 2009-03-20 derivados poli-substituídos de 2-aril -6-fenil-imidazo [1,2-a] piridinas poli-substituídos, o respectivo preparo e a prespectiva aplicação em terapêutica

Country Status (23)

Country Link
US (1) US8507520B2 (pt)
EP (1) EP2262769B1 (pt)
JP (1) JP5508385B2 (pt)
KR (1) KR20100129775A (pt)
CN (2) CN102036959B (pt)
AR (1) AR070993A1 (pt)
AU (1) AU2009253234B2 (pt)
BR (1) BRPI0909415A2 (pt)
CA (1) CA2719125C (pt)
CL (1) CL2009000696A1 (pt)
CO (1) CO6290657A2 (pt)
EA (1) EA201071112A1 (pt)
FR (1) FR2928922B1 (pt)
IL (1) IL208246A0 (pt)
MA (1) MA32247B1 (pt)
ME (1) ME01029B (pt)
MX (1) MX2010010316A (pt)
NZ (1) NZ588151A (pt)
SG (1) SG189679A1 (pt)
TW (1) TW200944202A (pt)
UY (1) UY31728A (pt)
WO (1) WO2009144394A1 (pt)
ZA (1) ZA201006728B (pt)

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JP7559059B2 (ja) 2019-09-30 2024-10-01 インサイト・コーポレイション 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物
MX2022005651A (es) 2019-11-11 2022-07-27 Incyte Corp Sales y formas cristalinas de un inhibidor de la proteina de muerte celular programada 1 (pd-1)/ligando de muerte celular programada 1 (pd-l1).
KR20230117573A (ko) 2020-11-06 2023-08-08 인사이트 코포레이션 Pd-1 및 pd-l1 억제제, 및 이의 염 및 결정형의 제조 방법
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SG189679A1 (en) 2013-05-31
AR070993A1 (es) 2010-05-19
WO2009144394A8 (fr) 2010-10-14
EP2262769B1 (fr) 2014-11-05
EP2262769A1 (fr) 2010-12-22
FR2928922A1 (fr) 2009-09-25
MA32247B1 (fr) 2011-04-01
ZA201006728B (en) 2011-11-30
UY31728A (es) 2009-11-10
JP5508385B2 (ja) 2014-05-28
NZ588151A (en) 2012-07-27
CA2719125A1 (fr) 2009-12-03
WO2009144394A1 (fr) 2009-12-03
KR20100129775A (ko) 2010-12-09
CN102036959B (zh) 2013-05-22
ME01029B (me) 2012-10-20
CL2009000696A1 (es) 2010-08-13
TW200944202A (en) 2009-11-01
MX2010010316A (es) 2010-12-14
AU2009253234B2 (en) 2013-07-11
US8507520B2 (en) 2013-08-13
IL208246A0 (en) 2010-12-30
JP2011515382A (ja) 2011-05-19
CN103193815A (zh) 2013-07-10
FR2928922B1 (fr) 2010-04-23
CN102036959A (zh) 2011-04-27
US20110065745A1 (en) 2011-03-17
CA2719125C (fr) 2016-07-26
EA201071112A1 (ru) 2011-04-29
AU2009253234A1 (en) 2009-12-03
CO6290657A2 (es) 2011-06-20

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