MX339668B - Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina. - Google Patents

Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina.

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Publication number
MX339668B
MX339668B MX2011006346A MX2011006346A MX339668B MX 339668 B MX339668 B MX 339668B MX 2011006346 A MX2011006346 A MX 2011006346A MX 2011006346 A MX2011006346 A MX 2011006346A MX 339668 B MX339668 B MX 339668B
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MX
Mexico
Prior art keywords
4alkyl
histamine
receptor
modulators
amide compounds
Prior art date
Application number
MX2011006346A
Other languages
English (en)
Inventor
Frank J Villani
Hua Zhong
Michael A Letavic
Neelakandha S Mani
Chennagiri R Pandit
John M Keith
Kiev S Ly
John E Mills
Original Assignee
Janssen Pharmaceutica N V *
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Publication date
Application filed by Janssen Pharmaceutica N V * filed Critical Janssen Pharmaceutica N V *
Publication of MX339668B publication Critical patent/MX339668B/es

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Abstract

Compuestos de piridilamida de Fórmula (I): (Ver fórmula (I)) en donde R1 es -alquilo de C1-4 o cicloalquilo monocíclico saturado; m es 1 ó 2; X es N o CH; Y es N o CRa; Ra es -H, -Z-Ar, -CH2NRbRC, -CN, -CO2alquilo de C1-4, -CO2H o CONRbRc; en donde Rb y Rc son cada uno de manera independiente -H o -alquilo de C1-4 y R2 es -H o -Z-Ar; con la condición de que uno de X y Y es N y uno de Ra y R2 es-Z-Ar; en donde Z es O o S; y Ar es un grupo fenilo o heteroarilo monocíclico no sustituido o sustituido con uno, dos o tres sustituyentes R3 en donde cada sustituyente R3 se selecciona de manera independiente del grupo que consiste de: halo, -alquilo de C1-4, -OH, -Oalquilo de C1-4, -Salquilo de C1-4, -CN, CONRdRe y -NO2 en donde Rd y Re son cada uno de manera independiente -H o -alquilo de C1-4 son moduladores del receptor H3 de la histamina útiles en el tratamiento de las enfermedades mediadas por el receptor H3 de la histamina.
MX2011006346A 2006-05-30 2007-05-25 Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina. MX339668B (es)

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Application Number Priority Date Filing Date Title
US80340706P 2006-05-30 2006-05-30
US82310806P 2006-08-22 2006-08-22
PCT/US2007/069723 WO2007143422A2 (en) 2006-05-30 2007-05-25 Substituted pyridyl amide compounds as modulators of the histamine h3 receptor

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EA018582B1 (ru) 2007-11-20 2013-09-30 Янссен Фармацевтика Н.В. Соединения циклоалкилокси- и гетероциклоалкилоксипиридина как модуляторы гистаминового рецептора н
WO2009067406A1 (en) * 2007-11-20 2009-05-28 Janssen Pharmaceutica N.V. Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
WO2009097995A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
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MX349489B (es) 2009-03-18 2017-07-31 Janssen Pharmaceutica Nv Proceso para la preparación de moduladores del receptor h3 de histamina.
SMT201700574T1 (it) 2011-07-07 2018-01-11 Gilead Sciences Inc Formulazioni delle combinazioni di darunavir
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
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US9321729B2 (en) 2016-04-26
IL195514A0 (en) 2009-09-01
JP2009538928A (ja) 2009-11-12
US20070281923A1 (en) 2007-12-06
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CA2653940A1 (en) 2007-12-13
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