EA200870585A1 - Замещённые пиридиламидные соединения в качестве модуляторов гистаминового н-рецептора - Google Patents

Замещённые пиридиламидные соединения в качестве модуляторов гистаминового н-рецептора

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Publication number
EA200870585A1
EA200870585A1 EA200870585A EA200870585A EA200870585A1 EA 200870585 A1 EA200870585 A1 EA 200870585A1 EA 200870585 A EA200870585 A EA 200870585A EA 200870585 A EA200870585 A EA 200870585A EA 200870585 A1 EA200870585 A1 EA 200870585A1
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Eurasian Patent Office
Prior art keywords
receptor modulators
hystamine
compounds
replaced
independently
Prior art date
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EA200870585A
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English (en)
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EA015555B1 (ru
Inventor
Джон М. Кейт
Майкл А. Летавич
Киев С. Ли
Неелакандха С. Мани
Джон Е. Миллз
Ченнагири Р. Пандит
Фрэнк Дж. Виллани
Хуа Чжун
Original Assignee
Янссен Фармацевтика Н.В.
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Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200870585A1 publication Critical patent/EA200870585A1/ru
Publication of EA015555B1 publication Critical patent/EA015555B1/ru

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Abstract

Пиридиламидные соединения формулы (I)где Rпредставляет собой -Салкил или насыщенный моноциклический циклоалкил; m равно 1 или 2; Х представляет собой N или СН; Y представляет собой N или CR; Rпредставляет собой -Н, -Z-Ar, -CHNRR, -CN, -COCалкил, -COH или -CONRR; где каждый из Rи Rнезависимо представляет собой -Н или -Салкил; Rпредставляет собой -Н или -Z-Ar; при условии, что один из Х и Y представляет собой N, а один из Rи Rпредставляет собой -Z-Ar; где Z представляет собой О или S; а Ar представляет собой фенильную или моноциклическую гетероарильную группу, незамещенную или замещенную одним, двумя или тремя заместителями R; где каждый из заместителей Rнезависимо выбран из группы, состоящей из галогена, -Салкила, -ОН, -ОСалкила, -SCалкила, -CN, -CONRRи -NO, где каждый из Rи Rнезависимо представляет собой -Н или -Салкил; где указанные соединения представляют собой модуляторы гистаминового Н-рецептора, которые могут быть использованы для лечения заболеваний, опосредуемых гистаминовым Н-рецептором.
EA200870585A 2006-05-30 2007-05-25 Замещенные пиридиламидные соединения в качестве модуляторов гистаминового h-рецептора EA015555B1 (ru)

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US80340706P 2006-05-30 2006-05-30
US82310806P 2006-08-22 2006-08-22
PCT/US2007/069723 WO2007143422A2 (en) 2006-05-30 2007-05-25 Substituted pyridyl amide compounds as modulators of the histamine h3 receptor

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EA015555B1 EA015555B1 (ru) 2011-08-30

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WO2007143422A2 (en) 2006-05-30 2007-12-13 Janssen Pharmaceutica N.V. Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
JP2009542706A (ja) * 2006-06-29 2009-12-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ３受容体の置換ベンズアミドモジュレーター
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US20090131416A1 (en) * 2007-11-20 2009-05-21 Allison Brett D Substituted pyrazinyl amide compounds as modulators of the histamine h3 receptor
WO2009067406A1 (en) * 2007-11-20 2009-05-28 Janssen Pharmaceutica N.V. Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
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