AR061419A1 - Compuestos de piridil amida sustituidos como moduladores del receptor de histamida h3 - Google Patents

Compuestos de piridil amida sustituidos como moduladores del receptor de histamida h3

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Publication number
AR061419A1
AR061419A1 ARP070102332A ARP070102332A AR061419A1 AR 061419 A1 AR061419 A1 AR 061419A1 AR P070102332 A ARP070102332 A AR P070102332A AR P070102332 A ARP070102332 A AR P070102332A AR 061419 A1 AR061419 A1 AR 061419A1
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AR
Argentina
Prior art keywords
alkyl
histamide
piridil
4alkyl
compounds replaced
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ARP070102332A
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English (en)
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Janssen Pharmaceutica Nv
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Publication of AR061419A1 publication Critical patent/AR061419A1/es

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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Reivindicacion 1: Un compuesto de Formula (1) donde R1 es alquiloC1-4 o cicloalquilo monocíclico saturado; m es 1 o 2; X es N o CH; Y es N o CRa; Ra es -H, -Z-Ar, -CH2NRbRc, CN, -CO2alquiloC1-4, -CO2H, o -CONRbRc; donde Rb y Rc son cada uno independientemente -H o alquilo C1-4; y R2 es -H o -Z-Ar; con la condicion de que uno de X e Y es N y uno de R1 y R2 es -Z-Ar; donde Z es O o S; y Ar es un grupo heteroarilo monocíclico o fenilo no sustituido o sustituido con uno, dos, o tres sustituyentes R3; donde cada sustituyente R3 se selecciona de manera independiente del grupo formado por: halo, -alquiloC1-4, -OH, -OalquiloC1-4, S-alquiloC1-4, -CN, -CONRdRe, y -NO2; donde Rd y Re son cada uno independientemente -H o -alquiloC1-4; o una sal farmacéuticamente aceptable, una prodroga farmacéuticamente aceptable, o un metabolito farmacéuticamente activo del mismo.
ARP070102332A 2006-05-30 2007-05-30 Compuestos de piridil amida sustituidos como moduladores del receptor de histamida h3 AR061419A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80340706P 2006-05-30 2006-05-30
US82310806P 2006-08-22 2006-08-22
US11/753,607 US7777031B2 (en) 2006-05-30 2007-05-25 Substituted pyridyl amide compounds as modulators of the histamine H3 receptor

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AR061419A1 true AR061419A1 (es) 2008-08-27

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US (4) US7777031B2 (es)
EP (1) EP2032536B1 (es)
JP (1) JP5285603B2 (es)
KR (1) KR101372941B1 (es)
CN (1) CN101495456B (es)
AR (1) AR061419A1 (es)
AU (1) AU2007256931B2 (es)
BR (1) BRPI0711873A2 (es)
CA (1) CA2653940C (es)
CR (1) CR10544A (es)
EA (1) EA015555B1 (es)
EC (1) ECSP088926A (es)
HK (1) HK1130471A1 (es)
IL (1) IL195514A (es)
MX (2) MX339668B (es)
MY (1) MY146506A (es)
NI (1) NI200800314A (es)
NO (1) NO341679B1 (es)
NZ (1) NZ573028A (es)
TW (1) TWI393715B (es)
WO (1) WO2007143422A2 (es)
ZA (1) ZA200810855B (es)

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CN103826616B (zh) 2011-07-07 2016-08-10 爱尔兰詹森科学公司 地瑞纳韦组合配制品
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