EA201692190A1 - Соединения фосфина золота (i) в качестве антибактериальных агентов - Google Patents

Соединения фосфина золота (i) в качестве антибактериальных агентов

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Publication number
EA201692190A1
EA201692190A1 EA201692190A EA201692190A EA201692190A1 EA 201692190 A1 EA201692190 A1 EA 201692190A1 EA 201692190 A EA201692190 A EA 201692190A EA 201692190 A EA201692190 A EA 201692190A EA 201692190 A1 EA201692190 A1 EA 201692190A1
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Eurasian Patent Office
Prior art keywords
branched alkyl
gold
antibacterial agents
phosphine compounds
cyclohexyl
Prior art date
Application number
EA201692190A
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English (en)
Inventor
Иэн Холмс
Алан Нэйлор
Габриэль Негойта-Гирас
Джонатан Пауэлл
Иэн Чарльз
Дагмар Альбер
Original Assignee
Осферикс Лимитед
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Priority claimed from GBGB1409401.5A external-priority patent/GB201409401D0/en
Priority claimed from GB201501969A external-priority patent/GB201501969D0/en
Application filed by Осферикс Лимитед filed Critical Осферикс Лимитед
Publication of EA201692190A1 publication Critical patent/EA201692190A1/ru

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    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
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    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
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    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
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    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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  • Inorganic Chemistry (AREA)

Abstract

Соединение формулы (I)для применения в профилактике или лечении бактериальной инфекции, где Rпредставляет собой метил, этил, изопропил, циклогексил или фенил; Rвыбран из метила, этила, изопропила, циклогексила и фенила; Rпредставляет собой этил, изопропил, циклогексил, фенил или пиридил; А представляет собой или S, или Se; Rвыбран из:где каждый из Y, Y, Y, Yи Yнезависимо выбран из СН или N, причем по меньшей мере три из Y, Y, Y, Yи Yпредставляют собой СН; V выбран из О, CH-OR, N-CO-Rили N-R; один из Y, Y, Yи Yвыбран из СН и N, а другие представляют собой СН; X выбран из NH, S или О; Rвыбран из O-Rили NHR; Rвыбран из Н и Cнеразветвленного алкила; Rпредставляет собой Cнеразветвленный алкил; Rвыбран из Н и Cнеразветвленного алкила; Rпредставляет собой Cнеразветвленный алкил; Rпредставляет собой Cнеразветвленный алкил или Cразветвленный алкил; Rвыбран из Cнеразветвленного алкила и СНСОН; Rпредставляет собой Н или Me; Rпредставляет собой Н или Me; Rпредставляет один или два необязательных метильных заместителя и n представляет собой целое число от 2 до 8.
EA201692190A 2014-05-28 2015-05-28 Соединения фосфина золота (i) в качестве антибактериальных агентов EA201692190A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1409401.5A GB201409401D0 (en) 2014-05-28 2014-05-28 Anti-bacterial compounds
GB201501969A GB201501969D0 (en) 2015-02-06 2015-02-06 Anti-bacterial compounds
PCT/GB2015/051550 WO2015181550A1 (en) 2014-05-28 2015-05-28 Gold (i)-phosphine compounds as anti-bacterial agents

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EA201692190A1 true EA201692190A1 (ru) 2017-03-31

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US (1) US20170204123A1 (ru)
EP (1) EP3148554A1 (ru)
JP (1) JP2017519817A (ru)
KR (1) KR20170012288A (ru)
CN (1) CN106459116A (ru)
AU (1) AU2015265714A1 (ru)
CA (1) CA2950384A1 (ru)
EA (1) EA201692190A1 (ru)
IL (1) IL249176A0 (ru)
MX (1) MX2016015625A (ru)
SG (1) SG11201609377TA (ru)
WO (1) WO2015181550A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
WO2016124936A1 (en) * 2015-02-06 2016-08-11 Auspherix Limited Inhibition of microbial persister cells
US10258640B2 (en) 2015-09-08 2019-04-16 Nanyang Technological University Method of inhibiting quorum sensing in Pseudomonas aeruginosa
GB201521238D0 (en) * 2015-12-02 2016-01-13 Auspherix Ltd Anti-bacterial compounds
GB201708844D0 (en) * 2017-06-02 2017-07-19 Auspherix Ltd Anti-bacterial compounds
CN112566919A (zh) * 2018-08-16 2021-03-26 雅盖隆大学 生物分子的缀合方法及金供体用于生物分子复合物形成的新用途
CN109369482B (zh) * 2018-12-07 2020-08-28 济源市万洋华康生物科技有限公司 一种l-硒代胱氨酸的制备方法
CN113135958B (zh) * 2021-04-08 2022-05-27 南京中医药大学 氮杂环卡宾硒-金化合物在制备抗耐碳青霉烯类鲍曼不动杆菌药物中的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883546A (en) * 1973-08-01 1975-05-13 Smithkline Corp S-heterocyclic derivatives of phosphine or phosphite gold mercaptides
WO1995014703A1 (en) * 1993-11-24 1995-06-01 Luminis Pty. Ltd. Triorganophosphinegold (i) thionucleobases with anti-tumor activity

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JP2017519817A (ja) 2017-07-20
US20170204123A1 (en) 2017-07-20
AU2015265714A1 (en) 2016-11-24
EP3148554A1 (en) 2017-04-05
WO2015181550A1 (en) 2015-12-03
IL249176A0 (en) 2017-01-31
CN106459116A (zh) 2017-02-22
SG11201609377TA (en) 2016-12-29
KR20170012288A (ko) 2017-02-02
CA2950384A1 (en) 2015-12-03
MX2016015625A (es) 2017-07-28

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