BRPI0506927A - compostos orgánicos - Google Patents

compostos orgánicos

Info

Publication number
BRPI0506927A
BRPI0506927A BRPI0506927-0A BRPI0506927A BRPI0506927A BR PI0506927 A BRPI0506927 A BR PI0506927A BR PI0506927 A BRPI0506927 A BR PI0506927A BR PI0506927 A BRPI0506927 A BR PI0506927A
Authority
BR
Brazil
Prior art keywords
alkyl
alkoxy
hydrogen
compounds
haloalkyl
Prior art date
Application number
BRPI0506927-0A
Other languages
English (en)
Inventor
Neil John Press
Roger John Taylor
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31971241&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0506927(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0506927A publication Critical patent/BRPI0506927A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

COMPOSTO ORGáNICO. A presente invenção refere-se aos compostos da fórmula (1) na forma livre ou de sal, onde Ar é fenila subistituída por um ou mais substituintes selecionados de halogênio, ciano e C~ 1~-C~ 8~-haloalquila, ou naftila, R¬ 1¬ é hidrogênio, fenila opcionalmente substituída por um ou mais substituintes selecionados de halogênio, ciano, hidróxi, C~ 1~-C~ 8~-alquila, C~ 1~-C~ 8~-haloalquila, C~ 1~-C~ 8~-alcóxi, C~ 1~-C~ 8~-alcóxi-C~ 1~-C~ 8~-alquila, carbóxi, C~ 1~-C~ 8~-alcoxicarbonila e acilóxi, ou R¬ 1¬ é um grupo heterocíclico monovalente de 5 ou 6 membros, R¬ 2¬ é hidrogênio, C~ 1~-C~ 8~-alquila, acila ou -CON(R¬ 3¬)R¬ 4¬, R¬ 3¬ e R¬ 4¬ são ou independentemente hidrogênio ou C~ 1~-C~ 8~-alquila, ou junto com o átomo de nitrogênio ao qual eles estão ligados significa um grupo heterocíclico monovalente de 5 ou 6 membros, e Y é um grupo de pirimidinila ou piridazinila, opcionalmente substituído por pelo menos um grupo de C~ 1~-C~ 8~-alquila, C~ 1~-C~ 8~-alcóxi, C~ 1~-C~ 8~-alquiltio, C~ 1~-C~ 8~-alquilamino, di(C~ 1~- C~ 8~-alquil)amino ou acilamino. Os compostos são úteis como farmacêuticos.
BRPI0506927-0A 2004-01-21 2005-01-20 compostos orgánicos BRPI0506927A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0401336.3A GB0401336D0 (en) 2004-01-21 2004-01-21 Organic compounds
PCT/EP2005/000542 WO2005070926A1 (en) 2004-01-21 2005-01-20 Thiazole derivatives as a2b antagonists

Publications (1)

Publication Number Publication Date
BRPI0506927A true BRPI0506927A (pt) 2007-06-05

Family

ID=31971241

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506927-0A BRPI0506927A (pt) 2004-01-21 2005-01-20 compostos orgánicos

Country Status (16)

Country Link
US (1) US20090233938A1 (pt)
EP (1) EP1709036B1 (pt)
JP (1) JP2007518767A (pt)
KR (1) KR20060129276A (pt)
CN (1) CN1910178B (pt)
AT (1) ATE388147T1 (pt)
AU (1) AU2005206290B2 (pt)
BR (1) BRPI0506927A (pt)
CA (1) CA2553010A1 (pt)
DE (1) DE602005005161T2 (pt)
ES (1) ES2300985T3 (pt)
GB (1) GB0401336D0 (pt)
PL (1) PL1709036T3 (pt)
PT (1) PT1709036E (pt)
RU (1) RU2374242C2 (pt)
WO (1) WO2005070926A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2270715B1 (es) 2005-07-29 2008-04-01 Laboratorios Almirall S.A. Nuevos derivados de pirazina.
JP5341516B2 (ja) * 2005-09-13 2013-11-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２−アニリン−４−アリール置換チアゾール誘導体
ES2274712B1 (es) 2005-10-06 2008-03-01 Laboratorios Almirall S.A. Nuevos derivados imidazopiridina.
AU2007227021B2 (en) 2006-03-17 2012-12-20 Gilead Sciences, Inc. Method of preventing and treating hepatic disease using A2B adenosine receptor antagonists
ES2350013T3 (es) * 2006-05-18 2011-01-14 F. Hoffmann-La Roche Ag Derivados de tiazolo-pirimidina/piridina-urea como antagonistas de receptor de adenosina a2b.
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
ES2424023T3 (es) 2007-10-18 2013-09-26 Janssen Pharmaceutica N.V. 1,2,4-triazoles trisustituidos
CN102066343B (zh) 2008-03-19 2013-12-04 詹森药业有限公司 作为烟碱乙酰胆碱受体调节剂的三取代1，2，4-三唑类
WO2009135944A1 (en) 2008-05-09 2009-11-12 Janssen Pharmaceutica Nv Trisubstituted pyrazoles as acetylcholine receptor modulators
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
CN109293652B (zh) * 2017-07-24 2021-10-22 四川科伦博泰生物医药股份有限公司 一种取代的噻唑衍生物及其用途
WO2019072143A1 (zh) * 2017-10-11 2019-04-18 上海迪诺医药科技有限公司 4-氨基吡啶衍生物、其药物组合物、制备方法及应用
EP3870573B1 (en) 2018-10-24 2023-08-02 LeadXpro AG Functionalized aminotriazines
CA3126735A1 (en) 2019-01-11 2020-07-16 Omeros Corporation Methods and compositions for treating cancer
WO2023139132A1 (en) * 2022-01-19 2023-07-27 Leadxpro Ag Functionalized aminothiazoles
GB2615307A (en) * 2022-01-28 2023-08-09 Adorx Therapeutics Ltd Antagonist compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064418A1 (en) * 1998-06-05 1999-12-16 Novartis Ag Aryl pyridinyl thiazoles
JP2000281685A (ja) * 1999-01-28 2000-10-10 Takeda Chem Ind Ltd チアゾロピリミジン化合物、その製造法および用途
WO2001030778A1 (en) * 1999-10-27 2001-05-03 Novartis Ag Thiazole and imidazo [4,5-b] pyridine compounds and their pharmaceutical use
GB0028383D0 (en) * 2000-11-21 2001-01-03 Novartis Ag Organic compounds
JP2002302445A (ja) * 2001-02-02 2002-10-18 Takeda Chem Ind Ltd Ｊｎｋ阻害剤
GB0123589D0 (en) * 2001-10-01 2001-11-21 Syngenta Participations Ag Organic compounds
US20050004134A1 (en) * 2001-11-08 2005-01-06 Hideo Tsutsumi Thiazole derivative and pharmaceutical use thereof

Also Published As

Publication number Publication date
US20090233938A1 (en) 2009-09-17
GB0401336D0 (en) 2004-02-25
ES2300985T3 (es) 2008-06-16
JP2007518767A (ja) 2007-07-12
DE602005005161T2 (de) 2009-03-19
WO2005070926A1 (en) 2005-08-04
AU2005206290B2 (en) 2008-12-04
PT1709036E (pt) 2008-05-28
CN1910178A (zh) 2007-02-07
KR20060129276A (ko) 2006-12-15
CN1910178B (zh) 2010-06-02
RU2374242C2 (ru) 2009-11-27
ATE388147T1 (de) 2008-03-15
RU2006130002A (ru) 2008-02-27
EP1709036B1 (en) 2008-03-05
DE602005005161D1 (de) 2008-04-17
PL1709036T3 (pl) 2008-08-29
AU2005206290A1 (en) 2005-08-04
CA2553010A1 (en) 2005-08-04
EP1709036A1 (en) 2006-10-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.