DE602005005161D1 - Thiazolderivate als a2b-antagonisten - Google Patents

Thiazolderivate als a2b-antagonisten

Info

Publication number
DE602005005161D1
DE602005005161D1 DE602005005161T DE602005005161T DE602005005161D1 DE 602005005161 D1 DE602005005161 D1 DE 602005005161D1 DE 602005005161 T DE602005005161 T DE 602005005161T DE 602005005161 T DE602005005161 T DE 602005005161T DE 602005005161 D1 DE602005005161 D1 DE 602005005161D1
Authority
DE
Germany
Prior art keywords
alkyl
alkoxy
hydrogen
haloalkyl
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005005161T
Other languages
English (en)
Other versions
DE602005005161T2 (de
Inventor
Neil John Press
Roger J Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31971241&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005005161(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE602005005161D1 publication Critical patent/DE602005005161D1/de
Application granted granted Critical
Publication of DE602005005161T2 publication Critical patent/DE602005005161T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602005005161T 2004-01-21 2005-01-20 Thiazolderivate als a2b-antagonisten Active DE602005005161T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0401336 2004-01-21
GBGB0401336.3A GB0401336D0 (en) 2004-01-21 2004-01-21 Organic compounds
PCT/EP2005/000542 WO2005070926A1 (en) 2004-01-21 2005-01-20 Thiazole derivatives as a2b antagonists

Publications (2)

Publication Number Publication Date
DE602005005161D1 true DE602005005161D1 (de) 2008-04-17
DE602005005161T2 DE602005005161T2 (de) 2009-03-19

Family

ID=31971241

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005005161T Active DE602005005161T2 (de) 2004-01-21 2005-01-20 Thiazolderivate als a2b-antagonisten

Country Status (16)

Country Link
US (1) US20090233938A1 (de)
EP (1) EP1709036B1 (de)
JP (1) JP2007518767A (de)
KR (1) KR20060129276A (de)
CN (1) CN1910178B (de)
AT (1) ATE388147T1 (de)
AU (1) AU2005206290B2 (de)
BR (1) BRPI0506927A (de)
CA (1) CA2553010A1 (de)
DE (1) DE602005005161T2 (de)
ES (1) ES2300985T3 (de)
GB (1) GB0401336D0 (de)
PL (1) PL1709036T3 (de)
PT (1) PT1709036E (de)
RU (1) RU2374242C2 (de)
WO (1) WO2005070926A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2270715B1 (es) 2005-07-29 2008-04-01 Laboratorios Almirall S.A. Nuevos derivados de pirazina.
NZ566036A (en) * 2005-09-13 2010-06-25 Janssen Pharmaceutica Nv 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor
ES2274712B1 (es) 2005-10-06 2008-03-01 Laboratorios Almirall S.A. Nuevos derivados imidazopiridina.
WO2007109547A2 (en) 2006-03-17 2007-09-27 Cv Therapeutics, Inc. Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists
JP5026511B2 (ja) 2006-05-18 2012-09-12 エフ．ホフマン−ラ ロシュ アーゲー アデノシンａ２ｂレセプターアンタゴニストとしてのチアゾロ−ピラミジン／ピリジン尿素誘導体
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
RU2474579C2 (ru) 2007-10-18 2013-02-10 Янссен Фармацевтика Нв Тризамещенные 1,2,4-триазолы
CA2714662C (en) 2008-03-19 2016-05-10 Janssen Pharmaceutica Nv Trisubstituted 1,2,4-triazoles as nicotinic acetylcholine receptor modulators
US8779158B2 (en) 2008-05-09 2014-07-15 Janssen Pharmaceutica Nv Trisubstituted pyrazoles as acetylcholine receptor modulators
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
CN109293652B (zh) * 2017-07-24 2021-10-22 四川科伦博泰生物医药股份有限公司 一种取代的噻唑衍生物及其用途
CN109651358B (zh) * 2017-10-11 2023-04-07 上海迪诺医药科技有限公司 4-氨基吡啶衍生物、其药物组合物、制备方法及应用
AU2019367187A1 (en) 2018-10-24 2021-03-25 Leadxpro Ag Functionalized aminotriazines
SG11202106963YA (en) 2019-01-11 2021-07-29 Omeros Corp Methods and compositions for treating cancer
WO2023139132A1 (en) * 2022-01-19 2023-07-27 Leadxpro Ag Functionalized aminothiazoles
GB2615307A (en) * 2022-01-28 2023-08-09 Adorx Therapeutics Ltd Antagonist compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4506399A (en) * 1998-06-05 1999-12-30 Novartis Ag Aryl pyridinyl thiazoles
JP2000281685A (ja) * 1999-01-28 2000-10-10 Takeda Chem Ind Ltd チアゾロピリミジン化合物、その製造法および用途
JP2003512467A (ja) * 1999-10-27 2003-04-02 ノバルティス アクチエンゲゼルシャフト チアゾールおよびイミダゾ（４，５−ｂ）ピリジン化合物ならびにそれらの医薬用途
GB0028383D0 (en) * 2000-11-21 2001-01-03 Novartis Ag Organic compounds
JP2002302445A (ja) * 2001-02-02 2002-10-18 Takeda Chem Ind Ltd Ｊｎｋ阻害剤
GB0123589D0 (en) * 2001-10-01 2001-11-21 Syngenta Participations Ag Organic compounds
JP2005510508A (ja) * 2001-11-08 2005-04-21 藤沢薬品工業株式会社 アデノシンアンタゴニストとしてのチアゾールピリダジノン類

Also Published As

Publication number Publication date
AU2005206290B2 (en) 2008-12-04
KR20060129276A (ko) 2006-12-15
RU2006130002A (ru) 2008-02-27
CA2553010A1 (en) 2005-08-04
EP1709036A1 (de) 2006-10-11
JP2007518767A (ja) 2007-07-12
CN1910178B (zh) 2010-06-02
WO2005070926A1 (en) 2005-08-04
CN1910178A (zh) 2007-02-07
BRPI0506927A (pt) 2007-06-05
PL1709036T3 (pl) 2008-08-29
RU2374242C2 (ru) 2009-11-27
US20090233938A1 (en) 2009-09-17
ES2300985T3 (es) 2008-06-16
ATE388147T1 (de) 2008-03-15
EP1709036B1 (de) 2008-03-05
DE602005005161T2 (de) 2009-03-19
GB0401336D0 (en) 2004-02-25
AU2005206290A1 (en) 2005-08-04
PT1709036E (pt) 2008-05-28

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: TAYLOR, ROGER J., HORSHAM, WEST SUSSEX, GB

Inventor name: PRESS, NEIL JOHN, HORSHAM, WEST SUSSEX, GB

8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN